排序方式: 共有13条查询结果,搜索用时 15 毫秒
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目的 系统了解中医药防治慢性萎缩性胃炎(CAG)领域的临床研究证据分布,总结疗效,为未来的研究提供指引。方法 借助涵盖消化领域多个优势病种的中医药循证文献大数据平台,检索其收录的2000—2020年发表的中医药防治CAG的临床研究、系统评价/Meta分析、指南与专家共识文献;对符合纳入标准文献的发表时间、研究类型,临床研究样本量及干预疗程,中医证候及体质相关观察性研究内容及分布,中医防治方案类别及作用(预防、治疗、康复/二级预防、不确定),临床评价指标等信息进行统计分析,并以图文结合形式呈现该领域证据分布。结果 共纳入文献796篇,包括775篇临床研究,19篇系统评价,2篇专家共识。年度文献发表量总体呈缓慢上升趋势,2015年及2019年文献发表量最高,均为51篇。临床研究类型以干预性研究为主,共714篇,包括随机对照临床试验518篇、非随机对照试验196篇;观察性研究61篇。有46.50%(332/714)的干预性研究的样本量为60~100例,47.48%(339/714)的干预性研究疗程为3~6个月,干预措施以中药治疗为主,结局指标多关注总有效率、内镜下表现、病理组织学、中医证候积... 相似文献
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目的 探究老年直肠癌患者术前中性粒细胞淋巴细胞比率(NLR)与淋巴结转移及预后的关系。方法 回顾性收集2019年2月—2020年2月我院收治的行直肠癌根治切除术且术后病理证实为直肠癌的老年患者102例作为观察对象。收集所有患者临床资料;采集血样标本测定中性粒细胞、淋巴细胞计数,并计算NLR。以NLR临界值为3.96作为分组标准,将102例患者分为高NLR组(NLR>3.96,n=40)和低NLR组(NLR≤3.96,n=62)。比较不同水平NLR患者肿瘤解剖学位置、肿瘤直径和淋巴结转移情况等临床病理资料。并对所有患者进行2年随访,分析影响患者预后的相关因素。结果 高NLR组和低NLR组老年直肠癌患者解剖学部位、糖尿病史、高血压史、肿瘤直径和肿瘤体积等临床病理参数之间比较差异均无统计学意义(均P>0.05),高NLR组存在淋巴结转移、远处转移和TNM分期越晚的患者占比较低NLR组多,且淋巴结转移、远处转移和TNM分期均是影响NLR的相关因素(P<0.05)。单因素分析结果显示,肿瘤直径和体积越大、出现淋巴结转移、远处转移、TNM分期越晚和NLR水平越高的患者生存率越低(... 相似文献
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日本血吸虫的扫描电镜观察 总被引:5,自引:0,他引:5
本文报告我国大陆品系日本血吸虫成虫的扫描电镜观察结果。成虫体壁呈海绵状,有明显而复杂的褶脊和凹窝,没有隆起的圆凸。口、腹吸盘、雄虫抱雌沟和雌虫后端均分布着大小不一的棘。在体壁上可查见两种形态和分布位置不同的感觉器官:一是具有单根纤毛的球状隆起感觉器,主要分布于体前端及吸盘;另一是周围隆起而中央凹陷的扁圆形感觉器,主要分布于抱雌褶的边缘及尾端。 相似文献
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Ma Jinxin马金鑫and He Yixun何毅勋Institute of Parasitic Diseases Chineso Academy of Medicat. Sciences Shanghai Institute of Entomology Academia Sini Shanghai 《中华医学杂志(英文版)》1981,94(1):63-72
The tegumental surface of the Chinese
'(mainland) strain of the adult Schistosoma ja-
ponicum is studied by scanning elect.ron micro-
;scopy (SEM). The dorsal surface of the male
bears ridges and pits but no bosses or spines,
presenting a sponge-like appearance. Many
spines cover the inner surfaces of both the oral
and ventral suckers. The lining of the gyne-
cophoric canal is covered with spines of various
sizes. The male gonopore is seen as a raised lip
a.t the anterior end of the gynecophoric canal.
The tegument of the female is ridged and pitted
.and possesses fewer minute spines at the poste-
rior end. There are two types of sensory or-
ganelles on the surface of S. ,japonicum, one
consisting of the papilla-like elevations with
openings located around the lateral edge of the
gynecophoric folds, the other being sensory bulbs
with a central cilium particularly abundant at
the anterior part and the suckers. 相似文献
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Presented below is an observation made withthe electron microscope and light microscope on 57specimens including thick yellowish tongue coating,thick yellowish creamy tongue coating,thin yello-wish tongue coating and thin yellowish creamy ton-gue coating,denuded tongue coating,blue-purpletongue tissue proper,cardinal red and light-coloredtongue tissue proper.The formation of thick tongue coating is relat-ed to acclerated hyperplasia,retarded cell degenera-tion,firmness of cell adhesion and reduction of thedesquamation rate in the tongue epithelium.Creamytongue coating may be related to an increase innumber and amount of discharge from the mem-brane-coating granules.The peculiar denuded tonguecoating results from certain inhibitory factors whichaffect epithelial keratinization,the formation and re-lease of membrane-coating granules,and the syn-thesis or activity of lysozyme.Discussed also arethe mechanism of genesis of such other pathologicaltongue features as yellowish tongue coating,blue-purple tongue tissue proper,and cardinal red andlight-colored tongue tissue proper. 相似文献
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He Yixun何毅勋Institute of PaTasitic Diseases Chinese Academ! o Medical Sciences Shanghai Gong Zuxun龚祖埙Institute of Biochemistry Academ.ia Sinica.Shanghai Ma Jinxin马金鑫Instituteo Entomology Acahlemia Sini Shanghai 《中华医学杂志(英文版)》1980,93(12):861-864
The surface of the egg shell of Schistosoma
japonicum appears quite rough by scanning
electron microscope (SiEM) and extremely comp-
licated in structure by transmission electron
microscope (TEM). The shell is composed of a
thin, very dense and apparently coritinuous
inner layer and a thick and moderately dense
outer layer. The outer surface of the egg shell
is covered with numerous bristle-like microspi-
cules, averaging 0.06 Lr. long and 0.02 11 in dia-
meter at the base. There are about 600 micros-
picules on l square micron egg shell surface.
Some spaced microspicule-like proj.ection
may also be found, averaging about 0.18X
0.06¨. The tops of these projections break and
drop off. 相似文献
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腹泻型肠易激综合征(IBS-D)是临床上常见的功能性胃肠病之一,发病机制多样,因其发作突然、缠绵难治,严重影响了患者的工作生活。IBS-D患者因病情反复难愈,影响生活常伴随焦虑、抑郁等精神症状。其焦虑,抑郁的状态亦可影响内脏感受,增加肠道敏感性,躯体症状与精神症状相互影响,加重病情。IBS-D的主要发病机制如内脏高敏感性、胃肠动力紊乱、肠道感染、社会心理因素等均与脑肠互动紊乱相关。IBS-D患者长期精神慢性应激状态易诱发脑肠互动功能紊乱,脑肠互动是脑肠轴调控胃肠功能的主要调控方式,以脑肠轴及脑肠肽为物质基础进行脑与肠之间的交互作用。中医认为IBS-D患者的主要证型为肝郁脾虚证,肝郁则情志不畅,而脑内各类神经递质的分泌及含量与情绪密切相关。痛泻要方为临床治疗IBS-D肝郁脾虚证的常用基础方,具有柔肝补脾,祛湿止泻的功能,临床疗效显著。目前已有多项动物实验、临床研究探讨痛泻要方治疗IBS-D的机制及其对脑肠互动功能及脑肠肽含量的影响,但未将肝主疏泄与脑肠互动联系起来。笔者以肝主疏泄与脑肠互动的相关性为切入点,基于脑肠互动紊乱探讨痛泻要方治疗IBS-D的机制,阐释三者之间的相关性。笔者综合近5年来痛泻要方治疗IBS-D及痛泻药方与脑肠互动关系的研究文献,探讨痛泻要方通过影响脑肠轴及脑肠肽来治疗IBS-D。 相似文献
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