病理性瘢痕中脂质过氧化产物和铜锌超氧化物歧化酶的变化

目的了解病理性瘢痕（增生性瘢痕与瘢痕疙瘩）中脂质过氧化产物和铜锌超氧化物歧化酶（copper，zinc-superoxide dismutase，CuZn-SOD）的变化。方法取2005年5月-2005年8月收治患者自愿捐献的标本。瘢痕疙瘩组10例，年龄16～35岁，平均病程2．2年；增生性瘢痕组10例，年龄17～32岁，平均病程8个月；正常皮肤组8例，年龄16～34岁。应用化学比色法测定3组标本中CuZn．SOD活力和丙二醛（malonaldehyde，MDA）含量，采用免疫组织化学方法观察CuZn-SOD蛋白在病理性瘢痕中的表达，并对其进行评分。结果正常皮肤组、增生性瘢痕组及瘢痕疙瘩组MDA含量分别为（0．8213±0．0864）、（1．1390±0．1067）、（1．1900±0．0748）nmol／mg prot；CuZn-SOD活力分别为（20．60±5．56）、（31．65±2．21）、（34．36±5．01）U／mg prot。增生性瘢痕组和瘢痕疙瘩组MDA含量与CuZn-SOD活力同正常皮肤组比较，差异均有统计学意义（P〈0．05）；增生性瘢痕组及瘢痕疙瘩组间比较，差异无统计学意义（P〉0．05）。免疫组织化学染色观察：3组表皮角质形成细胞和真皮成纤维细胞均有CuZn．SOD蛋白阳性表达。正常皮肤组、增生性瘢痕组及瘢痕疙瘩组在表皮角质形成细胞中免疫组织化学评分分别为（2．20±0．45）、（4．14±0．90）、（4．43±0．79）分；在真皮成纤维细胞中评分分别为（1．60±0．89）、（4．00±0．82）、（4．43±0．53）分。增生性瘢痕组和瘢痕疙瘩组CuZn-SOD蛋白表达与正常皮肤组比较，差异有统计学意义（P〈0．05）；增生性瘢痕组及瘢痕疙瘩组间比较，差异无统计学意义（P〉0．05）。结论病理性瘢痕中脂质过氧化产物MDA含量增加，CuZn-SOD活力升高、表达增强。     

甲氧氯普胺致锥体外系反应19例分析

本院自1999年8～12月共收治由于甲氧氯普胺(灭吐灵)的过量使用而致锥体外系反应19例,其中男13例,女6例。年龄8～70岁,平均年龄38岁;8～17岁11例,男7例,女4例;18～70岁8例,男6例,女2例。患者多因腹胀、腹痛、反酸、恶心等,去当地卫生院、诊所、卫生室取得3～5种不等药品,其中有     

妊娠并发霰粒肿23例分析

妊娠期并发霰粒肿临床上并非少见．且其病情转归有一定规律性可寻，现将笔者近年诊治的资料比较完整的23例报告如下，并对其发病原因进行初探。～、临床资料1．一般资料：本文23名孕妇，最小年龄19岁，最大年龄37岁，单眼患病22例，双眼患病1例，均为上睑板腺囊肿，除1例为多发     

“井”字缝合局部皮瓣成形矫正乳头内陷

目的:探寻治疗乳头内陷的较佳手术方案。方法:2002年3月至2006年8月对29只乳头内陷畸形用"井"字缝合或加作局部"Z"字成形、乳腺真皮瓣填充矫正手术。结果:术后外形好,乳头感觉正常,切口瘢痕不明显。随访3～17个月,重度内陷畸形病例有3个乳头轻度回缩,余无复发。结论:该方法对于有哺乳要求的患者不失为一种可选择的有效方法。     

基层医院抢救婴幼儿急性咽后脓肿的体会

基层医院抢救婴幼儿急性咽后脓肿的体会王怀胜，杜朝文６３５７０９四川省通江县沙溪中心医院地处边远地区或山区的基层医院，由于医疗条件限制和交通不方便，给急性咽后脓肿的救治带来一定困难，特别是婴幼儿患者。现将我们最近收治的患儿，其资料比较完整的且曾漏诊的１...     

采用闭式复位经皮穿针固定治疗不稳定型Co11es'骨折的疗效观察

不稳定型Colles'骨折处理困难,治疗不当会导致骨折畸形愈合及功能障碍等并发症.自1995年以来我们开始采用闭式复位经皮克氏针内固定治疗经传统手法治疗失败或出现畸形愈合的不稳定型Colles'骨折,并将其与传统方法及手术切开复位法进行疗效对照,结果如下.     

吸入性损伤患者早期气管切开拔管时机及后期并发症分析

Objective To investigate the appropriate extubation time and treatment of late complications after early tracheotomy in patients with moderate or severe inhalation injury. Methods One hundred and fifty patients ( 105 males and 45 females) with inhalation injury were admitted to our hospital from January 2000 to January 2009. Among them, 109 out of 129 cases with moderate inhalation injury received early tracheotomy, and all 21 cases with severe inhalation injury received early tracheotomy. Data were collected for analysis as follows: ( 1 ) incidence of re-intubation due to suffocation and pneumonia incidence after extubation within 2 weeks or after 2 weeks post inhalation injury (PⅡ), and mortality rate within the first week after injury were recorded. (2) Conservative treatments including expectorant, oral antibiotics, and absolute bedrest were recommended for patients who had severe cough, hoarseness or poor pulmonary function after late extubation and closure of tracheostomy wound. Fiberoptic bronchoscopy findings ( tracheostenosis degree, granuloma formation rate, vocal cord paralysis rate) and pulmonary function index ( FEV1 ) data were collected and analyzed in 30 cases with moderate inhalation injury and 10 cases with severe inhalation injury within 3 months after injury for follow-up. Data were processed with t test or chi-square test. Results There was no obvious difference in the rate of re-intubation after extubation in patients with moderate inhalation injury between those done within 2 weeks PⅡ ( 15/70, 21.4% ) and those done after 2 weeks PⅡ (2/25, 8.0% ) ( x 2 = 1.52, P ＞ 0.05 ). Pneumonia incidence in patients of moderate inhalation injury with extubation within 2 weeks PⅡ (21/70, 30.0% ) was lower than those with extubation after 2 weeks PⅡ (15/25, 60.0% ) (x 2= 7.04, P ＜ 0.05). Levels of above-mentioned indexes in patients with severe inhalation injury extubated in diffferent stages were similar to those of patients with moderate inhalation injury.Within the first week after injury, mortality rate of patients with severe inhalation injury was higher than that of patients with moderate inhalation injury ( x 2 = 11.90, P ＜ 0.05 ). During follow-up, tracheostenosis rate in patients with moderate or severe inhalation injury was 100.0%; granuloma formation rate and vocal cord paralysis rate in patients with severe inhalation injury were higher than those of patients with moderate inhalation injury ( with x 2 value respectively 4.59, 13.47, P values all below 0.05 ). The FEV1 value of patients with moderate inhalation injury in the 1st, 2nd, 3rd month after injury was respectively higher than that of patients with severe inhalation injury ( with t value respectively 5.48, 12. 10, 6.25, P values all below 0.05). The values recovered to normal level in the 3rd month after injury. Conclusions Extubation time of tracheotomy for patients with moderate or severe inhalation injury within 2 weeks or after 2 weeks PⅡ has its own advantage and disadvantage, and it should be performed according to specific conditions of each patient. Conservative treatment is optional for late complications of respiratory system.     

耳部瘢痕疙瘩个体化的综合治疗

目的 探讨耳部瘢痕疙瘩手术切除方式和术后放疗等综合治疗的疗效. 方法 2000年1月-2005年12月收治42例(71侧) 耳部瘢痕疙瘩患者.男8例,女34例;年龄16～50岁,平均26.2岁.病程6个月～4年.穿耳孔32例,创伤7例,耳部病变手术3例.瘢痕疙瘩范围 0.3 cm × 0.3 cm×0.2 cm～6.0 cm×4.0 cm×1.0 cm,形状呈球形、哑铃形、结节形.根据瘢痕疙瘩不同大小和范围,选择不同术式,切除瘢痕并行缺损修复.术后24 h内,高能电子束照射 10 次,每次2 Gy,总剂量20 Gy,对有复发倾向者,及时行"得宝松"1 mg 及 2%利多卡因按1∶3 混合液局部瘢痕内注射3次,每3周1次. 结果 术后患者切口均Ⅰ期愈合,皮瓣均成活.37例(64侧)获随访 1 年,获临床治愈;5 例(7侧)于术后3～6个月有复发倾向,及时局部注射"得宝松"后未见复发.根据刘文阁等疗效标准判定治愈37例,显效5例. 结论 耳部瘢痕疙瘩尽早采用个体化手术方式,结合早期放疗,可取得满意效果,是治疗的选择方案之一.     

股二头肌肌瓣复合局部皮瓣修复坐骨结节周围重度褥疮创面

褥疮常发生于长期卧床的患者,以骶尾部及坐骨结节周围较为高发,临床上以预防为主,一旦发牛,治疗较为棘手.坐骨结节周围较难寻找合适的肌皮瓣来修复创面,2005年1月至2007年1月我们采用股二头肌肌瓣复合局部皮瓣对12例坐骨结节周围重度褥疮创面进行了修复,现报告如下.