向《新医学》贺喜

欣闻贵刊被评为国家百种重点期刊,并获得国家新闻出版总署颁发的获奖证书,特向贵刊的编辑及全体员工热烈祝贺!贵刊在多次获奖的基础上,又获国家级大奖,真令读者欢欣鼓舞!医者最希望读到高质量的专业刊物,贵刊多次获得殊荣,质量之好不言而喻。望全体员工继续辛勤耕耘,力争更上一层楼!     

IS THE SEVERITY OF OSTEOSCLEROSIS OF FLUOROSIS PROPORTIONAL TO THE DOSE OF FLUORIDE INTAKE?

Histomorphometric study was made on a series of sections of undecalcified epiphyseal femoral specimens from rats with experimental fluorosis. The results revealed osteosclerosis in Group A (5 ppm) being more severe than that in Group B (25 ppm) With the increase of fluoride dose, the parameters fell down instead of increased in parallel. There is seemingly a threshold over which osteosclerosis in fluorosis becomes less severe. In contrast to Bely's conclusion the authors proposed that, fluoride toxi- city, besides decreasing the number of osteoblasts, may also activate the osteoblasts. The number of osteoblasts may be increased with relative lower dose of fluoride also. The net outcome is the in crement in bone volume. When toxic dose of fluoride is higher enough (higher than the proposed threshold), however, the number of osteoblasts and its activity are inhibited. So are the osteocytes. This interpretation may be the cytological basis for osteosclerosis in the experimental fluorosis.     

王树臣经验治疗肩关节脱位

肩关节脱位是临床骨伤科常见病,多发病,占全身关节脱位的5%.我院近6年来,收治单纯性肩关节脱位45例,运用王树臣经验,坐式.旋转.上举手法复位治疗肩关节单纯性脱位,夹板固定以及中药本院协定方,取得良好疗效,现在总结报告如下:     

正常人骨动力学的初步研究

正常人骨动力学参数在我国还是空白,本文对6名不同年龄正常人骨动力学的几个基本参数进行了初步测量和研究,借以了解正常人骨动力学特点,及其对一些代谢性骨病的诊断意义。     

游离股前外侧皮瓣移植修复患者足部外伤皮肤软组织缺损的临床效果分析

目的分析与探讨游离股前外侧皮瓣移植修复患者足部外伤皮肤软组织缺损的临床效果。方法选取该院在2015年2月—2016年2月份所接收的30例足部外伤皮肤软组织缺损的患者,所有的患者均给予游离股前外侧皮瓣移植修复的治疗方式,对患者进行6~12个月的随访,观察患者足部缺损修复区的形态、色泽、感觉和排汗等功能的具体恢复情况。结果治疗后所有的患者的临床症状均有明显的改善,其排汗功能,以及修复区的质地情况较为理想;只有1例患者的皮瓣颜色与周围皮肤存在较大差异,其余29例情况良好;所有的患者的感觉功能恢复良好,均达到S2以上水平;在外形方面有4例患者并不是十分满意,根据患者的情况对其进行二次修复整形。结论给予足部外伤皮肤软组织缺损患者采取游离股前外侧皮瓣移植修复术可有效提高患者的临床治疗效果,具有非常重要的意义和价值,值得在临床中广泛的推广和应用。     

自体骨移植与生物材料修复下颌骨缺损的比较

目的：用组织学观察的方法及分析植入材料在成骨过程中的骨动力学变化比较自体骨移植和胶原羟基磷灰石植入修复下颌骨缺损的效果。方法：本实验将自体骨、胶原羟基磷灰石分别植入10头中国试验用小型猪下颌骨缺损内，采用常规组织学观察，测量并统计基本的骨动力学参数，从定量、动态的角度，研究分析各自在修复过程中骨生长情况。结果：胶原羟基磷灰石植入后比自体骨植入后骨再建发生早，说明前者也具有良好的成骨作用，可较早地促进新生骨生长。结论：胶原羟基磷灰石、自体骨修复下颌骨缺损，其前者可以免除患者自体二处手术供骨的痛苦及心理负担，优于自体骨移植修复，便于临床推广、应用。     

合并软骨病的原发性甲状旁腺机能亢进症的骨矿化障碍不均一性

本文应用四环素双标记法对3名合并软骨病的原发性甲状旁腺机能亢进病人髂骨的不脱钙切片进行了观察,并用Mop-Videoplan影像分析系统进行了初步的骨形态计量学测量。结果表明,这些病人有不同程度的骨矿化障碍不均一性。文章尝试性地解释了出现这种现象的可能机制。     

BONE DYNAMIC CHANGES IN EXPERIMENTAL FLUOROSIS OF RATS

Fifteen hybrid rats divided int0 3 groups (A, B and C) were fed for 250 days with distilled, 50 ppm and 80 ppm NaF water respectively. Before exsanguination, doubled tetracycline labelings were made on all of the experimental animals for bone dynamic study. The available data suggest that the primary mineralization and matrix synthesis in group B and C were significantly inhibited, indicating the toxic effects of high fluoride on osteoblasts. For a better understanding of the pathogenesis of osteos clerosis, osteomalacia and osteoporosis in endemic fluorosis, we wou.lld suggest that fluoride be used not only as a stimulator for bone formation as is being recommended in the treatment of postmeno pausal ostcoporosis accompanied somewhat by osteosclerosis, but also as an inhibitor for matrix synthesis and primary mineralization through its toxic effects on osteoblast. We believe that the pathology of fluorosis depends largely on the dose of fluoride intake.     

氮化硅复合骨内种植体的骨计量学研究

目的 研究新型氮化硅陶瓷复合种植体周转骨界面的动态变化。方法 采用４只Ｂｅａｇｌｅ犬作实验动物,氮化硅复合羟基磷灰石咱植体、单一氮化硅种植体为实验组,钛合金种植体及钛合金复合羟基磷灰石种植体为对照组。分期植入动物股骨内,取不同期骨标本制备磨片,用骨计量学方法分析比较不同种植体蚧面骨的生长代谢情况,从定量、动态的角度对其生物相容性给予评价。结果 １个月时氮化硅复合种植体－－骨界面的矿化沉积速率参数均     

Kallmann综合征的骨动力学改变

Kallmann综合征是一种低促性腺性性腺功能低下(hypogonadotropic hypogonadism),主要临床表现为性腺发育不良和嗅觉丧失,部分病人可出现骨量减少(osteopenia)。我们用四环素双标记法于骨活