依诺肝素致重度Ⅱ型血小板减少症患者的药学监护

临床药师参与1例重度Ⅱ型依诺肝素诱导性血小板减少症（heparin-induced thrombocytopenia，HIT）患者的诊治，通过采用病例分析和文献复习的方法，协助治疗方案的审核、调整和优化，为患者提供优质的药学监护服务，促进药物的合理使用。临床医师及药师应关注肝素类药物引起的血小板减少症，治疗期间应加强血小板计数的监测和出血反应的监护。     

医院药房及药库现代化信息系统的应用探讨

针对现阶段计算机的普及及迅速发展,探讨医院跟进并改革信息系统后能够带来的众多益处、尤其是计算机系统信息开发在医院药房和药库中发挥的巨大作用,应用现代化信息系统,实现对医院发展的推动作用。     

Meta-analysis of Concurrent Chemoradiotherapy Comparison of Taxanes and Platinum versus 5-Fluorouracil and Platinum in Nasopharyngeal Carcinoma Treatment

Background: To evaluate the efficacy and safety of the regimen of concurrent chemoradiotherapy (CCRT) with taxanes and platinum versus the regimen of CCRT with 5-fluorouracil (5-FU) and platinum in nasopharyngeal carcinoma (NPC) treatment. Methods: Medline, the Cochrane library, and the Chinese medical literature database were searched for eligible studies. Meta-analysis was performed by Review Manager (Version 5.2). Results: Six random controlled trials (RCTs) including 514 patients met our criteria. Meta-analysis showed that the regimen of CCRT with taxanes and platinum had an improved significant difference in complete remission (CR) and less incidence rate in adverse reactions (AR) such as gastrointestinal impairment grade III-IV, liver and kidney impairment grade I-II and radiodermatitis grade III-IV versus the conventional regimen of CCRT with 5-FU and platinum, while the long-term effectiveness rate of overall survival (OS), locoregional failure-free survival (LFFS), or distant metastasis failure-free survival (DMFS) between the two groups was therapeutic equivalence. Conclusion: The regimen of CCRT with taxanes and platinum in NPC therapy may be more efficacy and safety than the conventional modality of 5-FU and platinum in CCRT. However, we need more high-quality studies of multi-center and randomized double-blind clinical trials to compare with, analyze, and confirm the findings further.     

注射用头孢唑林钠与丹皮酚磺酸钠注射液配伍稳定性研究

目的：观察注射用头孢唑林钠与丹皮酚磺酸钠注射液在0.9%氯化钠注射液中的配伍稳定性。方法模拟临床使用条件,用高效液相色谱法测定头孢唑林钠与丹皮酚磺酸钠配伍后6 h内的相对百分含量,并观察其外观、不溶性微粒数及pH变化。结果头孢唑林钠与丹皮酚磺酸钠配伍后,在室温下放置6 h,配伍液的外观、不溶性微粒数、pH及含量均无明显变化。结论注射用头孢唑林钠与丹皮酚磺酸钠注射液在0.9%氯化钠注射液中配伍后,室温下6 h内可使用。