高效液相色谱法测定人血浆中阿莫西林浓度及药代动力学

高效液相色谱法测定人血浆中阿莫西林浓度及药代动力学谭力周继红罗楠袁倚盛（南京军区南京总医院中心仪器分析科，南京２１０００１）阿莫西林（ａｍｏｘｉｃｉｌｉｎ）为β内酰胺类抗生素，其抗菌谱广，口服受食物影响小，对大多数病人耐受性良好，因而在临床上得以广泛...     

Comparison of digitized radiographic alveolar features between 20- and 70-year-old women. A preliminary study.

The purpose of this investigation was to determine whether a difference exists in four digital image features, extracted from standardized periapical radiographs of the maxillary alveolar bone, between younger and older women. These features included mean pixel intensity, I(x); pixel intensity variance, var I(x); mean absolute Fourier transform coefficient, magnitude of F(u); and mean spatial first moment of the absolute Fourier coefficients, M1. The interproximal bone between the maxillary canine and lateral incisor was analyzed in two groups of 10 younger and older women with mean ages of 24 and 74 years, respectively. I(x) was significantly less in the 70-year-old group than in the 20-year-old group (p = 0.01), as were magnitude of F(u) (p less than 0.05) and M1 (p less than 0.01). Var I(x) tended to be significantly less in the 70-year-old group (p = 0.06). We conclude that in women a measurable diminution in the magnitude of these four bony features comes with age.     

抗胆碱药3-(2-苯基-2-环戊基-2-羟基-乙氧基)奎宁环烷的立体化学和构效关系

研究了强效抗胆碱药dl-3-(2-苯基-2-环戊基-2-羟基-乙氧基)-奎宁环烷的四个光学异构体的两种不对称合成方法,用HPLC检测了异构体含量,讨论了构效关系。     

An analysis of the components in UW solution using the isolated perfused rabbit liver

The isolated perfused rabbit liver model has been used to determine the essential components of the UW solution for hepatic preservation by simple cold storage. Livers were stored on ice for 48 hr after initial flushing with the solution being tested, and then reperfused at 38 degrees C in an isolated perfusion circuit; bile flow and enzyme (SGOT, SGPT, and LDH) release during a 2-hr period were recorded. All solutions tested contained phosphate (25 mM) as a buffer and magnesium sulfate (5 mM). Sodium can be substituted for potassium without adverse effects. Lactobionate, raffinose and glutathione cannot be omitted; all other components can be eliminated without altering the effectiveness of the solution in this model.