To analyze the clinical and pathological features of patients with anti-neutrophilic cytoplasmic antibody (ANCA)-associated vasculitic (AASV)-kidney injury (AASVKI).
Methods
From January 2015 to December 2018, a total of 101 AASVKI patients treated in the First Hospital of Jilin University were divided into 2 groups (the pANCA-positive group and the cANCA-positive group) for comparison; 63 patients were performed renal biopsy and divided into 3 groups according to pathological results [the non-crescent nephritis group (non-C), the crescent nephritis group (C), and the sclerotic nephritis group (S)] for comparison.
Results
Compared with the Group pANCA, Group cANCA exhibited higher incidence of eye involvement (P?=?0.039) and skin mucosa destruction (P?=?0.045), higher serum creatinine (Scr) (P?<?0.001), higher 24-h urine protein quantification (P?=?0.045), but lower hemoglobin (Hb) (P?<?0.001). Compared with Group non-C, Group C had higher Scr (P?<?0.001) and urinary red blood cells (P?=?0.010), lower estimated glomerular filtration rate (eGFR) (P?=?0.003), hemoglobin (HD)-dependence (P?=?0.042), and higher mortality rate within 1 year (P?=?0.005); compared with Group S, Group C had faster onset of erythrocyte sedimentation rate (ESR) (P?=?0.031), higher urinary red blood cells (P?=?0.029), and lower incidence of HD-dependence (P?=?0.038).
Conclusions
AASVKI patients with positive cANCA have poor renal function, among whom the patients with crescent type have poorer renal function than those with non-crescent type, have higher urinary red blood cells while lower HD-dependence than those with sclerotic type.
Taxonomically related concepts like “bee” and “butterfly” and thematically related concepts like “bee” and “honey” have different roles in similarity judgments. We examined the complex impact of taxonomic and thematic relations on similarity and difference judgments via ERPs in a S1–S2 paradigm. Subjects were required to remember a word denoting some object or animal (S1), and compare that to a second word (S2) that was either thematically related, taxonomically related or unrelated to S1, making a “high” or “low” similarity and difference judgments in separate blocks. We found two main differences that suggest thematic and taxonomic relations engage distinct neural processes. The first difference is an N400 effect peaking between 300 ms and 400 ms that is more negative for unrelated words than for thematically and taxonomically related words. The second difference is a frontally distributed P600 peaking between 500 ms and 600 ms that is larger for taxonomically related words than for both unrelated and thematically related words. These results suggest that the dual process model for perceiving similarity is superior to the comparison only model of similarity judgments, and furthermore, provide evidence that the thematic relations are dissociative from taxonomic relations in making similarity and difference judgments. 相似文献
目的 探讨肾癌组织中肿瘤细胞周期相关蛋白(cell-cycle-related and expression-elevated protein in tumor,CREPT)的表达与临床病理特征和生存率的关系。方法 纳入90例于2014至2016年间在北京大学人民医院接受了根治性肾切除术并经组织学证实的肾癌患者,运用免疫组织化学方法检测这些患者的癌组织和癌旁组织中CREPT的表达,并结合临床病理资料分析CREPT表达水平与患者TNM分期和Fuhrman分级的关系。通过Kaplan-Meier生存分析及多因素COX回归分析CREPT表达与预后的关系。结果 46.7%(42/90)的患者癌组织中CREPT表达为高水平,而在癌旁组织中所有患者CREPT表达均为低水平,组间比较差异有统计学意义(P<0.05)。CREPT的表达水平与TNM分期(P=0.001)和Fuhrman分级(P<0.001)有关联,但与性别(P=0.149)、年龄(P=0.605)、肿瘤大小(P=0.673)和组织学类型(P=0.756)无关。截至2018年12月,有85例患者完成随访。Kaplan-Meier分析显示,CREPT高表达患者总生存时间和无瘤生存时间均低于CREPT低表达患者,差异有统计学意义(P<0.05)。多因素COX回归分析显示,患者总生存时间及无瘤生存时间与CREPT的表达水平有关(P<0.05)。结论 CREPT在肾癌组织中呈高表达,表达水平与临床分期、分级以及患者预后密切相关。 相似文献
A novel "omics" approach, chemomics, was presented here on the basis of the experience in studies of Traditional Chinese Medicine (TCM) Formulas and systems biology. Chemomics represents a novel approach to investigate the composition of a chemome and the relationships among the elements of the chemome. A chemome is defined as the whole chemical system that consists of all of the chemical substances and/or chemical constituents input into the biological system being investigated. A multi-level solution for chemomics study with corresponding technology was proposed. When its application in TCM formula, investigations may be conducted on three-level chemomes step by step and then the development on TCM Qingkailing was introduced as an example. Chemomics is the development and supplement of current systems biology, providing an approach for the assay of chemical complex system and facilitating the study of the interaction between the biological complex system and external chemical complex system. Since the therapy of TCM formula just represents the interaction between such two complex systems, application of chemomics approach will greatly promote its research and development. 相似文献
Human longevity continues to increase world-wide, often accompanied by decreasing birth rates. As a larger fraction of the population thus gets older, the number of people suffering from disease or disability increases dramatically, presenting a major societal challenge. Healthy ageing has therefore been selected by EU policy makers as an important priority (http://www.healthyageing.eu/european-policies-and-initiatives); it benefits not only the elderly but also their direct environment and broader society, as well as the economy. The theme of healthy ageing figures prominently in the Horizon 2020 programme (https://ec.europa.eu/programmes/horizon2020/en/h2020-section/health-demographic-change-and-wellbeing), which has launched several research and innovation actions (RIA), like “Understanding health, ageing and disease: determinants, risk factors and pathways” in the work programme on “Personalising healthcare” (https://ec.europa.eu/research/participants/portal/desktop/en/opportunities/h2020/topics/693-phc-01-2014.html). Here we present our research proposal entitled “ageing with elegans” (AwE) (http://www.h2020awe.eu/), funded by this RIA, which aims for better understanding of the factors causing health and disease in ageing, and to develop evidence-based prevention, diagnostic, therapeutic and other strategies. The aim of this article, authored by the principal investigators of the 17 collaborating teams, is to describe briefly the rationale, aims, strategies and work packages of AwE for the purposes of sharing our ideas and plans with the biogerontological community in order to invite scientific feedback, suggestions, and criticism. 相似文献