全文获取类型
收费全文 | 903篇 |
免费 | 43篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 38篇 |
妇产科学 | 16篇 |
基础医学 | 92篇 |
口腔科学 | 8篇 |
临床医学 | 65篇 |
内科学 | 318篇 |
皮肤病学 | 27篇 |
神经病学 | 15篇 |
特种医学 | 38篇 |
外科学 | 119篇 |
综合类 | 14篇 |
预防医学 | 25篇 |
眼科学 | 46篇 |
药学 | 37篇 |
中国医学 | 5篇 |
肿瘤学 | 82篇 |
出版年
2023年 | 2篇 |
2022年 | 12篇 |
2021年 | 71篇 |
2020年 | 47篇 |
2019年 | 29篇 |
2018年 | 43篇 |
2017年 | 37篇 |
2016年 | 37篇 |
2015年 | 30篇 |
2014年 | 53篇 |
2013年 | 34篇 |
2012年 | 73篇 |
2011年 | 71篇 |
2010年 | 40篇 |
2009年 | 22篇 |
2008年 | 43篇 |
2007年 | 46篇 |
2006年 | 41篇 |
2005年 | 30篇 |
2004年 | 31篇 |
2003年 | 17篇 |
2002年 | 21篇 |
2001年 | 9篇 |
2000年 | 12篇 |
1999年 | 8篇 |
1998年 | 9篇 |
1997年 | 3篇 |
1996年 | 1篇 |
1995年 | 4篇 |
1994年 | 2篇 |
1992年 | 3篇 |
1991年 | 11篇 |
1990年 | 5篇 |
1989年 | 4篇 |
1988年 | 5篇 |
1987年 | 9篇 |
1986年 | 5篇 |
1985年 | 8篇 |
1984年 | 6篇 |
1983年 | 2篇 |
1981年 | 1篇 |
1979年 | 6篇 |
1977年 | 2篇 |
1974年 | 1篇 |
1972年 | 1篇 |
1969年 | 1篇 |
排序方式: 共有948条查询结果,搜索用时 31 毫秒
1.
Uday Yanamandra Prateek Deo Kamal Kant Sahu Ram Vasudevan Nampoothiri Nalini Gupta Anusree Prabhakaran Deb Prasad Dhibhar Alka Khadwal Gaurav Prakash Man Upadesh Singh Sachdeva Deepesh Lad Neelam Varma Subhash Varma Pankaj Malhotra 《Clinical Lymphoma, Myeloma & Leukemia》2019,19(3):183-189.e1
Background
Multiple myeloma (MM) is a hematologic malignancy of plasma cell origin. MM primarily affects bone marrow, but extramedullary sites can also be involved. Myelomatous pleural effusion (MPE) is an atypical and rare complication of MM. We aimed to systematically study the incidence and clinicopathologic profile of patients with MPE in a real-world setting.Patients and Methods
In this retrospective study, 415 consecutive patients with MM managed at a tertiary care center in North India during a study period of January 1, 2010 to December 31, 2015 were evaluated for MPE. The patients with MPE were analyzed for their clinical profile, diagnosis, treatment, and outcomes.Results
Of these 415 patients, 11 (2.65%) patients had MPE. The median age of the study population was 50 years with male preponderance. The majority of these patients had immunoglobin (Ig)G Kappa disease. All patients had higher than International Staging System stage I disease. MPE was a presenting feature at MM diagnosis in 45.45% (n = 5) of the patients, whereas the rest developed MPE during follow-up. MPE presented predominantly (81.8%) as a unilateral effusion. Concurrent extramedullary involvement at other site was seen in 45.45% (n = 5), with 3 (27%) patients having concurrent myelomatous ascites. Six of these were managed aggressively, whereas 5 patients opted for palliation. The outcomes were dismal (90.9% mortality), with a median survival of 2.47 months.Conclusion
MPE is a rare entity, and positive outcomes of therapy remain low with dismal prognosis. 相似文献2.
This case presentation supports the observation that initial cerebrospinal fluid findings can be normal in newborn infants with sepsis syndrome who then develop evidence for meningeal involvement. Therefore, if initial lumbar puncture results are negative, a repeat lumbar puncture is recommended to look for meningitis in newborns that are critically ill with sepsis syndrome. 相似文献
3.
G R Verma Lileshwar Kaman Gurpreet Singh Rajinder Singh Arunanshu Behera Shashank Mohan Bose 《Indian journal of gastroenterology》2006,25(1):16-19
AIM: Retrospective analysis of experience with management of external duodenal fistula (EDF) without using total parenteral nutrition (TPN). METHOD: Medical records of 31 patients with EDF following closure of duodenal ulcer perforation, treated over a 7-year period (1994-2001), were studied. Twenty-one patients (68%) had evidence of sepsis at presentation or during the course of treatment. None could afford TPN for optimum time. All patients received hospital-based enteral nutrition through nasojejunal tube, besides supportive medical treatment and/or surgery. Peritonitis or failure to insert nasojejunal tube for enteric alimentation led to early surgery. RESULTS: Two patients died of septicemia and multi-organ failure within 48 hours of admission. Fourteen patients (48.3%) initially received conservative treatment (Group I); six of them later required surgery. Fifteen patients (51.7%) underwent early surgery due to peritonitis (n=9) or failure to establish enteral feeding (n=6) (Group II); wound infection, intra-abdominal abscess and septicemia were more common in these patients than those in Group I. Survival rate was higher in Group I than in Group II (86% versus 40%; p< 0.05). Septicemia and gastrectomy were the independent factors associated with high mortality. CONCLUSIONS: EDF can be satisfactorily managed without TPN. Successful placement of enteral feeding line, supportive treatment and delayed surgery can achieve survival in 85% of patients. Minimum intervention is recommended when early surgery is performed in peritonitis or to establish enteral feeding line. 相似文献
4.
5.
6.
Purpose The poor prognosis in patients with floating knee injuries is mainly contributed to articular involvement(Fraser’s typeⅡ).This study aims to evaluate and compare the functional outcomes among different Fraser’s typeⅡfloating knee injuries after surgical management.Methods Twenty-seven patients with Fraser’s typeⅡfloating knee injuries(54 fractures)between September 2014 and December 2015 were enrolled prospectively in this study and were distributed according to Fraser’s floating knee classification into three different groups as typeⅡA(ipsilateral femoral shaft and tibial intra-articular involvement,n=11),typeⅡB(ipsilateral tibial shaft and femoral intra-articular involvement,n=9)and typeⅡC(both femoral and tibial intra-articular involvement,n=7).The differences among the groups were evaluated and compared.The functional outcomes of these injuries at one year were analyzed using Knee Injury and Osteoarthritis Outcome Score(KOOS)which covers 5 subscales of pain,other symptoms,activities of daily living,sports and recreation,and quality of life.The result was also compared with standardized age-sex matched healthy population using paired samples t-test.Results All the patients were male,and the injury mechanism was solely roadside accident.The mean age was 29.8 years and injury severity score 17.9(comparable in all the three groups).Most injuries were observed on the right side(20 cases,74.1%).Based on paired samples t-test,the KOOS score of patients with Fraser’s typeⅡA was found to be better than that of typeⅡB and typeⅡC.Compared with the reference age-sex matched control group,patients with Fraser’s typeⅡB andⅡC fractures had significantly lower mean score in all KOOS subscales(all p<0.01).However,Fraser’s typeⅡA only revealed significant difference regarding the subscales of activities of daily living(p<0.0001),sports and recreation(p<0.0001),and quality of life(p<0.0001).Conclusion The results of this study show that patients with Fraser’s typeⅡA fractures had a better functional outcome as compared to those with typeⅡB andⅡC fractures.This might be due to the open intra-articular involvement of the distal femur of the latter two fracture types. 相似文献
7.
Maria Bindu Bagh Ishita Guha Thakurta Mallika Biswas Prajna Behera Sasanka Chakrabarti 《Biogerontology》2011,12(2):119-131
A combination of antioxidants (N-acetyl cysteine, α-lipoic acid, and α-tocopherol) was selected for long term oral supplementation
study in rats for protective effects on age-related mitochondrial alterations in the brain. Four groups of rats were chosen:
young control (6–7 months); aged rats (22–24 months); aged rats (22–24 months) on daily antioxidant supplementation from 18 month
onwards and young rats (6–7 months) on daily antioxidant supplementation from 2 month onwards. The brain mitochondrial functional
parameters, status of antioxidant enzymes and accumulation of oxidative damage markers were measured in the four groups of
rats. A significant decrease in complex IV activity and a loss of transmembrane potential and phosphorylation capacity along
with an increased accumulation of oxidative damage markers and compromised antioxidant enzyme status were noticed in aged
rat brain mitochondria as compared to that in young controls, but in aged rats supplemented with oral antioxidants the mitochondrial
alterations were largely prevented. Antioxidant supplementation in young rats had no effect on mitochondrial parameters investigated
in this study. The results have implications in biochemical and functional deficits of brain during aging as well as in neurodegenerative
disorders. 相似文献
8.
9.
Seema Sepat U. K. Behera A. R. Sharma T. K. Das Ranjan Bhattacharyya 《Proceedings of the National Academy of Sciences, India. Section B.》2014,84(3):561-571
Conservation agriculture improves productivity and soil quality, but most of the research results are only confined to the rice–wheat system. Hence, a long term field experiment was conducted at Indian Agricultural Research Institute, New Delhi during 2008–2009 to 2011–2012 on a sandy loam soil to study the effect of tillage and crop establishment techniques, and residue management practices on system productivity, residual nutrient status, microbial biomass carbon, microbial biomass nitrogen and enzymatic activities under a pigeonpea–wheat cropping system. It was observed that zero tillage gave 5.4 and 2.3 % higher pigeonpea and wheat yield, respectively, over conventional tillage. Similarly, it resulted in 9.6 and 4.9 % higher Kjeldahl N and extractable K, respectively and the plots under zero tillage had 20.6, 8.0 and 6.1 % higher dehydrogenase and acid and alkaline phosphatase activities, respectively, over conventional tillage. Application of crop residue at 3 t/ha provided 14.3 and 34.4 % higher pigeonpea and wheat grain yield, respectively, over no residue. Further, organic C, Kjeldahl N and Olsen’s P in soil were enhanced by 7.4, 6.9 and 7.5 %, respectively, due to residue compared to no residue plots. Combined application of pigeonpea + wheat residue at 3 t/ha resulted in higher dehydrogenase (20.9 µg triphenylformazan/g/h), β-glucosidase (145 µg p-nitrophenol/g/h), and acid phosphatase activities (24.5 µg p-nitrophenol/g/h) than the single application of wheat or pigeonpea residue in either season or no residue control. 相似文献
10.
S Sharma R Sarin U K Khalid N Singla P P Sharma D Behera 《The international journal of tuberculosis and lung disease》2008,12(1):74-80
SETTING: Paediatric Pulmonology Department, TB Institute, New Delhi, India. OBJECTIVE: To evaluate the outcome of the DOTS strategy for paediatric pulmonary tuberculosis (TB). DESIGN: Retrospective analysis of 1098 children. RESULTS: The mean age of the children included in the study was 11.2 years, with more females (61.7%) than males (38.3%). In the 0-5, 6-10 and 11-14 year age groups, the percentage of patients was respectively 18.3%, 26.6% and 55.1%. Patients were registered as new cases (87.7%), relapses (1.9%), failures (1.0%), defaulters (5.0%), transferred in (0.9%) and others (3.5%). Of the total number of cases, 414 were smear-positive and 404 smear-negative, while sputum status was not known for 280 patients. Sputum positivity increased with age. Category I, II and III regimens were started by respectively 50.6%, 10.5% and 38.9% patients. The cure rate was 92.4% (302/327) for new and 92% (80/87) for retreatment cases (chi(2)(1) = 0.02, P = 0.901), but the treatment completion rate was significantly higher for new cases (97%, 636/656) than retreatment cases (53.6%, 15/28) (chi(2)(1) = 100.8, P < 0.001). The overall success rate was 95.4% and 82.6% for new and retreatment cases, respectively (chi(2)(1) = 30.35, P < 0.001). Overall, the rates for default, failure and death in the study were respectively 3%, 1.9% and 1%. CONCLUSION: DOTS appears to be a highly efficacious treatment strategy. 相似文献