原发性肾滑膜肉瘤一例报告并文献复习

Objective To discuss the presentations, pathologic features, diagnosis and treatment of primary synovial sarcoma of the kidney. Methods One case of primary synovial sarcoma of the kidney was reported and the relevant literature was reviewed. A 55-year-old man was admitted with complaint of right abdomen and flank pain for 5 h. Computerized tomography revealed a 12.5 cm × 11.0 cm × 9. 0 cm mass located at the middle and lower pole of the right kidney. The patient was taken radical nephrectomy. Results The diagnosis of primary synovial sarcoma of the kidney in the patient was confirmed by postoperative pathology. Under microscope, tumor was typically mitotically active, monomorphic spindle cells growing in intersecting fascicles or in solid sheets with epithelial differentiation. In some areas a haemangiopericytoma-like pattern was found. Immunohistochemical staining showed that the tumor cells were positive for the markers Vimentin, CD99 and Bcl-2, but CK was negative. The patient died of local recurrence and multi-metastasis at 8 months after surgery. Conclusions Primary synovial sarcoma of the kidney is extremely rare with a high grade of malignancy,and its prognosis is poor. The diagnosis depends on pathological features, Immunohistochemical studies and RT-PCR detection. Radical resection combined with chemicaltherapy is considered to be the most reliable treatment so far.     

原发性肾滑膜肉瘤一例报告并文献复习

目的 总结原发性肾滑膜肉瘤的临床表现、病理特点和诊治方法.方法 原发性肾滑膜肉瘤患者1例,男,55岁.因右腰背及上腹部疼痛5 h入院.无尿频、尿急、尿痛、血尿、发热等症状.CT检查示右肾中下极恶性占位可能,累及右肾门、肾动静脉及肝脏.行右肾肿瘤根治性切除术.结果 病理检查:肿瘤大小12.5 cm×11.0 cm×9.0 cm.镜下瘤细胞呈梭形、束状排列,细胞异型,可见核分裂相,部分区域见增生的薄壁血管,肿瘤呈浸润性生长,伴发炎症及大量坏死、出血.免疫组化染色示Vimentin、CD99、Bcl-2阳性,CK阴性.病理诊断为原发性肾滑膜肉瘤.患者术后2个月出现局部复发及肝肺转移,予异环磷酰胺、表阿霉素化疗1疗程,患者不能耐受.术后8个月死亡.结论 原发性肾滑膜肉瘤是一种罕见、高度恶性的肿瘤,预后不良,确诊需依赖病理检查、免疫组织化学及RT-PCR检测.根治性切除辅以化学治疗可行.     

两步法建立标准通道经皮肾镜取石术治疗上尿路结石:附208例报告

目的 探讨应用两步法建立标准皮肾通道经皮肾镜取石术的安全性和有效性.方法 2007年11月至2010年12月,应用彩超引导下两步法建立标准通道经皮肾镜取石术治疗上尿路结石患者208例,共235侧上尿路结石,其中包括:孤立肾12例,肾盏憩室合并结石3例,髓质海绵肾3例.结石纵径1.7~8.0 cm,横径1.6~5.5 cm.结果 208例均一期成功建立经皮肾镜碎石通道.203例行一期取石术,5例行二期取石术.平均通道建立时间15.7±12.3 min,平均手术时间72.6±33.9 min.一期手术清石率88.5%,二期手术清石率为93.6%.术中、术后输血患者16例.并发液气胸1例,灌注液外渗3例,无感染性休克及肠道、肝、脾等腹腔脏器损伤.结论 两步法建立标准皮肾通道的经皮肾镜取石术是安全和有效的方法.     

泌尿系硅结石1例

<正>我院收治1例泌尿系结石患者,其成分为"硅结石",现报道如下。1病例报告患者女性,53岁,农民,因"左腰腹部疼痛3月"入院,在当地医院诊断泌尿系结石,行4次体外震波碎石治疗,未排出结石。既往体健。泌尿系CT提示单个结石,位于左输尿管中上段,第四腰椎平面,1.3cm×1.0cm×1.0cm,CT值:最小值为366 Hu,最     

输尿管镜下碎石清石术治疗输尿管上段、肾盂及肾上盏结石(附30例报告)

目的 探讨输尿管镜下应用瑞士EMS三代碎石、清石设备处理输尿管上段结石、肾盂及肾上盏内结石的临床疗效.方法 2005年12月～2008年5月,用上述方法治疗结石30例.结石大小:长径1.2～2.2 cm,横径0.8～1.2 cm,并发中重度肾积水21例,28例曾行体外冲击波碎石治疗.结果 30例中28例1次碎石成功,成功率93.3%.失败的2例中有1例因输尿管呈"N"扭曲致进镜失败而改行开放手术,1例有较大的肾孟结石碎石后残留结石,留置D-J管后行体外冲击波碎石治疗.结论 榆尿管镜下气压弹道联合超声碎石设备处理榆尿管上段、肾盂及肾上盏内结石可以取得良好的治疗效果.     

原发性肾滑膜肉瘤一例报告并文献复习

Objective To discuss the presentations, pathologic features, diagnosis and treatment of primary synovial sarcoma of the kidney. Methods One case of primary synovial sarcoma of the kidney was reported and the relevant literature was reviewed. A 55-year-old man was admitted with complaint of right abdomen and flank pain for 5 h. Computerized tomography revealed a 12.5 cm × 11.0 cm × 9. 0 cm mass located at the middle and lower pole of the right kidney. The patient was taken radical nephrectomy. Results The diagnosis of primary synovial sarcoma of the kidney in the patient was confirmed by postoperative pathology. Under microscope, tumor was typically mitotically active, monomorphic spindle cells growing in intersecting fascicles or in solid sheets with epithelial differentiation. In some areas a haemangiopericytoma-like pattern was found. Immunohistochemical staining showed that the tumor cells were positive for the markers Vimentin, CD99 and Bcl-2, but CK was negative. The patient died of local recurrence and multi-metastasis at 8 months after surgery. Conclusions Primary synovial sarcoma of the kidney is extremely rare with a high grade of malignancy,and its prognosis is poor. The diagnosis depends on pathological features, Immunohistochemical studies and RT-PCR detection. Radical resection combined with chemicaltherapy is considered to be the most reliable treatment so far.     

肾结石经输尿管软镜碎石术后血清神经导向因子-1、结缔组织生长因子水平对肾损伤的预测价值

目的 探讨血清神经导向因子-1(Netrin-1)、结缔组织生长因子(CTGF)对肾结石经输尿管软镜碎石术后肾损伤的预测价值。方法 2020年3月～2022年3月我院收治的肾结石病人104例,均采用经输尿管软镜碎石术治疗,选取同期我院健康体检者98例为对照组。将输尿管软镜碎石术后肾结石病人分为肾损伤组(58例)和非肾损伤组(46例)。使用酶联免疫吸附法(ELISA)检测血清Netrin-1、CTGF的表达水平。采用单因素分析及多因素Logistic回归分析肾结石经输尿管软镜碎石术后出现肾损伤的影响因素,采用受试者工作特性(ROC)曲线评估血清Netrin-1、CTGF对肾结石经输尿管软镜碎石术后肾损伤的预测价值。结果 研究组血清Netrin-1、CTGF表达水平均高于对照组;肾损伤组血清Netrin-1、CTGF水平高于非肾损伤组;多因素Logistic回归分析显示,Netrin-1≥300 ng/L、CTGF≥0.80 ng/L是输尿管软镜碎石术后肾损伤的危险因素(P<0.05)。血清Netrin-1、CTGF在预测经输尿管软镜碎石术后肾结石病人发生肾损伤的AUC分别为0.73...     

急诊输尿管镜治疗输尿管结石致急性肾功能衰竭(附24例报告)

目的 探讨急诊输尿管镜下气压弹道碎石术治疗输尿管结石致急性肾功能衰竭的效果.方法 对24例诊断明确的患者采用急诊行输尿管镜下气压弹道碎石术治疗,其中孤立肾5例,一侧输尿管结石对侧肾萎缩12例,双侧输尿管结石7例.结果 24例患者共31侧结石均碎石成功,梗阻解除,21例患者血肌酐及尿素氮恢复致正常,3例合并有慢性肾功能不全的患者血肌酐恢复到200umol/L以下,无严重并发症.结论 输尿管镜下气压弹道碎石术治疗输尿管结石致肾功能衰竭具有成功率高、损伤小、恢复快、并发症少、可同时处理双侧结石等优点,在具备条件的医疗单位应作为首先的治疗方法.     

不同结石评分法预测输尿管软镜碎石术后结石清除率的准确性比较

目的比较不同结石评分法预测输尿管软镜碎石术(RIRS)后结石清除率的准确性。方法回顾性分析2017年6月至2020年12月南京医科大学附属明基医院和青岛阜外医院收治的227例行RIRS肾结石患者的临床资料。男152例, 女75例;年龄(53.0±10.4)岁;结石位于左侧133例, 右侧94例;体质量指数(26.9±2.1)kg/m2;无或轻度肾积水163例, 中度肾积水40例, 重度肾积水24例。结石最大径(22.7±12.8) mm;结石位于上段输尿管、肾上盏或肾盂44例, 肾中盏23例, 肾下盏157例, 位于肾盏憩室3例。结石CT值(778.3±350.4)HU。美国麻醉医师协会(ASA)分级Ⅰ级86例, Ⅱ级129例, Ⅲ级12例。根据不同结石评分法的评分标准, 利用术前泌尿系CT+三维重建结果分别对患者术前结石特征进行评分。比较结石清除组和结石残留组临床特征的差异。采用logistic回归模型分析改良S.T.O.N.E.、RUSS、改良S-ReSC、R.I.R.S.、SHA.LIN、Ito列线图、S.O.L.V.E.、清石指数评分与结石清除率的相关性。绘制受试者工作特征(R...