Objective: To develop valid animal model for otitis media of effusion and to study the relation of paratubular muscles in the functioning of Eustachian tube.
Methods: Two different methods were used to induce middle ear disease: (1) Excision of tensor veli platini and levetor veli platini muscles (TVP and LVP); and (2) Injection of botulinum toxin type A on TVP and LVP.
Result: Otomiscroscopic, tympanograph, and pathological examination showed the presence of middle ear disease in those animals whose TVP was excised and paralyzed, but on those groups of animals whose LVP was excised and paralyzed, abnormalities were seen. 相似文献