全文获取类型
收费全文 | 280篇 |
免费 | 30篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 14篇 |
妇产科学 | 7篇 |
基础医学 | 29篇 |
口腔科学 | 8篇 |
临床医学 | 26篇 |
内科学 | 36篇 |
皮肤病学 | 14篇 |
神经病学 | 33篇 |
特种医学 | 45篇 |
外科学 | 67篇 |
综合类 | 4篇 |
预防医学 | 8篇 |
眼科学 | 7篇 |
药学 | 3篇 |
肿瘤学 | 6篇 |
出版年
2022年 | 5篇 |
2021年 | 8篇 |
2020年 | 15篇 |
2019年 | 14篇 |
2018年 | 11篇 |
2017年 | 8篇 |
2016年 | 9篇 |
2015年 | 9篇 |
2014年 | 10篇 |
2013年 | 12篇 |
2012年 | 16篇 |
2011年 | 15篇 |
2010年 | 12篇 |
2009年 | 5篇 |
2008年 | 12篇 |
2007年 | 26篇 |
2006年 | 17篇 |
2005年 | 24篇 |
2004年 | 19篇 |
2003年 | 14篇 |
2002年 | 9篇 |
2001年 | 8篇 |
2000年 | 2篇 |
1999年 | 4篇 |
1998年 | 1篇 |
1997年 | 2篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 3篇 |
1992年 | 2篇 |
1990年 | 1篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1983年 | 1篇 |
1982年 | 4篇 |
1972年 | 1篇 |
1970年 | 1篇 |
1968年 | 1篇 |
1967年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有311条查询结果,搜索用时 687 毫秒
1.
In-vitro activity of rifabutin against rifampicin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations 总被引:2,自引:0,他引:2
The relationship between resistance to rifampicin and rifabutin and genetic alterations in the rpoB gene of 41 rifampicin-resistant isolates of Mycobacterium tuberculosis was evaluated. Although 35 isolates with rifampicin MICs > or = 32 mg/L were also rifabutin-resistant, six isolates with rifampicin MICs of 2-16 mg/L were susceptible to rifabutin (MIC < or = 0.5 mg/L). Mutations Asp516Val, Asp516Tyr, Leu533Pro and the double mutation Met515Ile and Leu533Pro influenced susceptibility to rifampicin, but not to rifabutin. All mutations at codons 531 and 526, except one isolate with a His526Cys mutation, correlated with resistance to both compounds. 相似文献
2.
Chemokine receptor CXCR4 expression in breast cancer as a potential predictive marker of isolated tumor cells in bone marrow 总被引:7,自引:3,他引:7
Cabioglu N Sahin A Doucet M Yavuz E Igci A O Yildirim E Aktas E Bilgic S Kiran B Deniz G Price JE 《Clinical & experimental metastasis》2005,22(1):39-46
Interactions between the CXCR4 chemokine receptor in breast cancer cells and the ligand CXCL12/SDF-1α are thought to play an important role in breast cancer metastases. In this pilot study, CXCR4 expression along with other biomarkers including HER2-neu and EGFR, were measured in primary tumor samples of patients with operable breast cancer to test whether any of these biomarkers alone and in combination could indicate breast cancer with high likelihood of metastasizing to bone marrow. Cytokeratin (CK) positive cells in bone marrow were identified by flow-cytometry following enrichment with CK 7/8 antibody-coupled magnetic beads. Primary tumors (n = 18) were stained with specific antibodies for CXCR4, HER2-neu, EGFR, and PCNA using an indirect avidin–biotin horseradish peroxidase method. The majority of the patients had T2/T3 tumors (72%), or lymph node involvement (67%) as pathologic characteristics that were more indicative of high-risk breast cancer. High CXCR4 cytoplasmic expression was found in 7 of 18 patients (39%), whereas 6 of 18 patients (33%) were found to have CK positivity in bone marrow. The median number of CK+ cells was 236 (range, 20–847) per 5 × 104 enriched BM cells. The presence of CK+ cells in bone marrow was found to be associated with increased expression of CXCR4 alone or in addition to EGFR and/or HER2-neu expression (P = 0.013, P = 0.005, and P = 0.025, respectively) in primary tumors. Furthermore, three patients with high CK positivity (>236 CK+ per 5 × 104 enriched bone marrow cells) in bone marrow exclusively expressed high levels of CXCR4 with EGFR/HER2-neu (P = 0.001). Our data suggest that high CXCR4 expression in breast cancer may be a potential marker in predicting isolated tumor cells in bone marrow. CXCR4 coexpression with EGFR/HER2-neu might further predict a particular subset of patients with high CK positivity in bone marrow. 相似文献
3.
4.
5.
Uzuner Selcuk Durcan Gizem Sahin Sezgin Bahali Kayhan Barut Kenan Kilicoglu Ali Guven Adrovic Amra Bilgic Ayhan Kasapcopur Ozgur 《Clinical rheumatology》2021,40(12):5025-5032
Clinical Rheumatology - Having a child with a chronic illness is a source of stress for the whole family, especially the primary caregiver. The aim of this study was to evaluate the associations... 相似文献
6.
Guven Gamze Samanci Bedia Gulec Cagri Hanagasi Hasmet Gurvit Hakan Gokalp Ebru Erzurumluoglu Tepgec Fatih Guler Suleyman Uyguner Oya Bilgic Basar 《Neurological sciences》2021,42(6):2497-2504
Neurological Sciences - Alzheimer’s disease (AD) can be either sporadic or familial, and familial forms of AD accounts for only 5% of the cases. So far, autosomal dominantly inherited... 相似文献
7.
8.
9.
10.
Ibrahim Ali Ozemir Cagri Bilgic Baris Bayraktar Sinan Aslan Ebru Zemheri Haydar Yalman Rafet Yigitbasi 《International journal of surgery case reports》2014,5(8):480-483