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新辅助治疗可缩小恶性肿瘤、破坏恶性肿瘤细胞以及降低手术难度。术前接受新辅助治疗已逐渐成为肿瘤患者常见治疗方式之一, 其对机体免疫系统、心血管系统、呼吸系统及全身多器官产生重要影响, 可能关系到围手术期管理决策。文章就接受新辅助治疗的恶性肿瘤患者的手术时机、术前预康复策略、麻醉管理方式及要点等进行综述, 以期为此类患者临床麻醉管理提供一定参考。此外, 如何改善接受新辅助治疗患者的预后, 确定最佳麻醉方式及药物使用, 有待进一步研究。 相似文献
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逆转录-多聚酶链反应(RT-PCR)技术现已较多应用于HCV感染的分子生物学诊断。为了解其与ELISA法检测抗一HCVIN的关系,我们对249例患者同时做此两项检测,作回顾性比较和分析。一、材料和方法HCV-RNA、RT-PCR试剂由本院分子生物实验室制备。检测方法为用30VI血清抽提HCV-R 相似文献
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Objective:To describe the use of the GlideScope in comparison with direct laryngoscopy for elective surgical patients requiring tracheal intubation. Methods:Two hundred patients, ASA Ⅰ - Ⅱ scheduled for elective surgery under general anesthesia requiring orotracheal intubation were selected. Information was collected identifying the patient demographics and airway assessment features (Mallampati oropharyngeal scale, thyromenta distance and mouth opening). In a random crossover design, after induction of anesthesia and neuromuscular block, the laryngoscopes were inserted in turn, and the views of the glottis at laryngoscopy (Cormack and Lehane scores) were compared. The tracchea was intubated using either the standard Macintosh laryngoscope or GlideScope after the second grading at laryngoscopy was done. Complications associated with intubating were recorded. Results: There were 200 patients including 107 males and 93 females, with mean age being 52±13 years, height 164.8±11.3 cm, weight 64.0±11. 5 kg, thyromental distance 6. 9± 1.1 cm, and mouth opening 5.7±0.5 cm. There was a significant association between the preoperative view of the oropharynx (Mallampati score) and the view of the glottis at laryngoscopy for both the direct Macintosh laryngoscope (P〈0. 001) and the GlideScope (P〈0. 001). Among 200 patients, 106 patients had the same C&L grade, 91 of remaining patients showed improvement in the C&L grade (P〈0. 001 ) obtained with GlideScope compared with the direct Macintosh laryngoscope. 3 of remaining patients showed better view of the glottis(C&L grade) with the direct Macintosh laryngoscope (grade 1) than with GlideScope (grade 2). There were no cases of failure to be intubated. There were no cases of dental or mucosal injury in all patients. Conclusion: GlideScope videolaryngoscope yielded comparable or superior laryngeal view compared with Macintosh laryngoscope. The new type of laryngoscope may have potential advantages for managing the d 相似文献
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目的:观察不同治疗方法对膝关节骨性关节炎的疗效差异及可能影响疗效的其他相关因素.方法:将1012例膝关节骨性关节炎患者按治疗时间分为5组,分析治疗前、治疗后1周、4周和24周后患者的VAS评分变化,根据患者自觉功能改善情况,计算改善非常好、好的患者比例率和总的改善率.结果:门诊治疗1周后患者VAS评分均显著下降,与治疗后其他时段相比,VAS评分最低,自觉功能改善非常好的比例最高,后三年治疗效果与前两年相比又有显著提高,尤其是后两年的远期效果,无论是VAS评分还是改善率等均显著升高.结论:局部注射治疗和关节腔内注射结合能显著提高膝关节骨性关节炎的治疗效果,而得宝松与施沛特的联合应用能显著改善远期效果,长期坚持口服药物能巩固疗效. 相似文献
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目的:用大鼠脑一氧化氮合酶(bNOS)的一个片段免疫家兔,产生可识别该酶本身的抗体.方法:根据亲水性、抗原性及产生α-螺旋、β-折叠、和β-转角的可能性,预测肽277-287位于该酶的抗原决定簇中.肽277-287经化学合成,与血蓝蛋白交联,免疫家兔,获得抗体.特异性用ELISA.免疫组织化学和蛋白印迹分析法鉴定.结果:抗体与大鼠小脑提取液可特异性结合;免疫组织化学染色结果与NADPH-黄递酶组织化学染色结果一致.它可结合分子量约150 kDa的蛋白。结论:该抗肽抗体可专一性识别大鼠脑组织中的bNOS. 相似文献
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目的:探讨中药外敷腹部对骨科老年患者便秘的影响。方法:将140个老年病人分为两组。对照组70例,观察组70例。对照组采用泻药或灌肠的方法;观察组进行中药烫熨腹部的方法。结果:2组在排出大便的时间上有显著性差异,P0.01。结论:中药烫熨腹部对于骨科老年患者在治疗便秘上具有明显的作用。 相似文献