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排序方式: 共有288条查询结果,搜索用时 15 毫秒
1.
Dr. Fritze 《Virchows Archiv : an international journal of pathology》1873,57(2):294-295
Ohne Zusammenfassung(Hierzu Taf. IV. Fig. 5–8. 相似文献
2.
A. Prader Bansi Schölmerich Uehlinger F. Steigerwaldt H. E. Bock Fritze F. Scheiffarth und H. Mathies 《Journal of molecular medicine (Berlin, Germany)》1966,44(23):1381-1384
Ohne Zusammenfassung 相似文献
3.
Lee YJ Hohoff C Domschke K Sand P Kuhlenbäumer G Schirmacher A Freitag CM Meyer J Stöber G Franke P Nöthen MM Fritze J Fimmers R Garritsen HS Stögbauer F Deckert J 《Neuroscience letters》2005,377(1):40-43
Several biochemical and pharmacological studies suggest that the catecholaminergic system involving the norepinephrine transporter (NET) is relevant for the pathogenesis of panic disorder. Three single nucleotide polymorphisms in the promoter or untranslated 5' region of the NET gene were investigated by means of RFLP analysis in a sample of 115 German patients with panic disorder and 115 matched controls. Statistical analysis failed to show association with the overall diagnosis of panic disorder. In the subgroup of patients with panic disorder without agoraphobia, however, two polymorphisms were found to be associated with the disease (G/C (rs2397771): p < 0.05; T/C (rs2242446): p < 0.01). While our data do not support a major function of the NET gene in the development of panic disorder, it may play a role in the subgroup of panic disorder without agoraphobia. 相似文献
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Deckert J Catalano M Syagailo YV Bosi M Okladnova O Di Bella D Nöthen MM Maffei P Franke P Fritze J Maier W Propping P Beckmann H Bellodi L Lesch KP 《Human molecular genetics》1999,8(4):621-624
A genetic contribution to the pathogenesis of panic disorder has been demonstrated by clinical genetic studies. Molecular genetic studies have focused on candidate genes suggested by the molecular mechanisms implied in the action of drugs utilized for therapy or in challenge tests. One class of drugs effective in the treatment of panic disorder is represented by monoamine oxidase A inhibitors. Therefore, the monoamine oxidase A gene on chromosome X is a prime candidate gene. In the present study we investigated a novel repeat polymorphism in the promoter of the monoamine oxidase A gene for association with panic disorder in two independent samples (German sample, n = 80; Italian sample, n = 129). Two alleles (3 and 4 repeats) were most common and constituted >97% of the observed alleles. Functional characterization in a luciferase assay demonstrated that the longer alleles (3a, 4 and 5) were more active than allele 3. Among females of both the German and the Italian samples of panic disorder patients (combined, n = 209) the longer alleles (3a, 4 and 5) were significantly more frequent than among females of the corresponding control samples (combined, n = 190, chi2 = 10.27, df = 1, P = 0.001). Together with the observation that inhibition of monoamine oxidase A is clinically effective in the treatment of panic disorder these findings suggest that increased monoamine oxidase A activity is a risk factor for panic disorder in female patients. 相似文献
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Robert C Wolf Mahmoud Rashidi Mike M Schmitgen Stefan Fritze Fabio Sambataro Katharina M Kubera Dusan Hirjak 《Schizophrenia bulletin》2021,47(2):433
Neurological soft signs (NSS) are well documented in individuals with schizophrenia (SZ), yet so far, the relationship between NSS and specific symptom expression is unclear. We studied 76 SZ patients using magnetic resonance imaging (MRI) to determine associations between NSS, positive symptoms, gray matter volume (GMV), and neural activity at rest. SZ patients were hypothesis-driven stratified according to the presence or absence of auditory verbal hallucinations (AVH; n = 34 without vs 42 with AVH) according to the Brief Psychiatric Rating Scale. Structural MRI data were analyzed using voxel-based morphometry, whereas intrinsic neural activity was investigated using regional homogeneity (ReHo) measures. Using ANCOVA, AVH patients showed significantly higher NSS in motor and integrative functions (IF) compared with non-hallucinating (nAVH) patients. Partial correlation revealed that NSS IF were positively associated with AVH symptom severity in AVH patients. Such associations were not confirmed for delusions. In region-of-interest ANCOVAs comprising the left middle and superior temporal gyri, right paracentral lobule, and right inferior parietal lobule (IPL) structure and function, significant differences between AVH and nAVH subgroups were not detected. In a binary logistic regression model, IF scores and right IPL ReHo were significant predictors of AVH. These data suggest significant interrelationships between sensorimotor integration abilities, brain structure and function, and AVH symptom expression. 相似文献
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Otte Marie-Luise Schmitgen Mike M. Kubera Katharina M. Wolf Nadine D. Fritze Stefan Geiger Lena S. Tost Heike Seidl Ulrich W. Meyer-Lindenberg Andreas Hirjak Dusan Wolf Robert C. 《European archives of psychiatry and clinical neuroscience》2022,272(6):985-995
European Archives of Psychiatry and Clinical Neuroscience - Insight into illness in schizophrenia (SZ) patients has a major impact on treatment adherence and outcome. Previous studies have linked... 相似文献
10.
Synthesis and Characterisation of Nanocomposite Mo-Fe-B Thin Films Deposited by Magnetron Sputtering
Paulius Malinovskis Stefan Fritze Justinas Palisaitis Erik Lewin Jrg Patscheider Per O. . Persson Ulf Jansson 《Materials》2021,14(7)
Several ternary phases are known in the Mo-Fe-B system. Previous ab initio calculations have predicted that they should exhibit a tempting mix of mechanical and magnetic properties. In this study, we have deposited Mo-Fe-B films with a Fe-content varying from 0–37 at.% using non-reactive DC (direct current) magnetron sputtering. The phase composition, microstructure, and mechanical properties were investigated using X-ray diffraction, scanning transmission electron microscopy, and nanoindentation measurements. Films deposited at 300 °C and with >7 at.% Fe are nanocomposites consisting of two amorphous phases: a metal-rich phase and a metal-deficient phase. Hardness and elastic modulus were reduced with increasing Fe-content from ~29 to ~19 GPa and ~526 to ~353 GPa, respectively. These values result in H3/E2 ratios of 0.089–0.052 GPa, thereby indicating brittle behaviour of the films. Also, no indication of crystalline ternary phases was observed at temperatures up to 600 °C, suggesting that higher temperatures are required for such films to form. 相似文献