收费全文 | 4690篇 |
免费 | 229篇 |
国内免费 | 4篇 |
耳鼻咽喉 | 54篇 |
儿科学 | 489篇 |
妇产科学 | 180篇 |
基础医学 | 564篇 |
口腔科学 | 65篇 |
临床医学 | 239篇 |
内科学 | 930篇 |
皮肤病学 | 73篇 |
神经病学 | 203篇 |
特种医学 | 76篇 |
外科学 | 575篇 |
综合类 | 100篇 |
预防医学 | 337篇 |
眼科学 | 189篇 |
药学 | 579篇 |
中国医学 | 24篇 |
肿瘤学 | 246篇 |
2021年 | 100篇 |
2020年 | 52篇 |
2019年 | 73篇 |
2018年 | 101篇 |
2017年 | 71篇 |
2016年 | 104篇 |
2015年 | 112篇 |
2014年 | 133篇 |
2013年 | 200篇 |
2012年 | 239篇 |
2011年 | 271篇 |
2010年 | 174篇 |
2009年 | 144篇 |
2008年 | 231篇 |
2007年 | 234篇 |
2006年 | 245篇 |
2005年 | 227篇 |
2004年 | 229篇 |
2003年 | 206篇 |
2002年 | 160篇 |
2001年 | 119篇 |
2000年 | 135篇 |
1999年 | 113篇 |
1998年 | 32篇 |
1997年 | 24篇 |
1996年 | 23篇 |
1995年 | 21篇 |
1994年 | 21篇 |
1993年 | 33篇 |
1992年 | 72篇 |
1991年 | 66篇 |
1990年 | 70篇 |
1989年 | 65篇 |
1988年 | 71篇 |
1987年 | 60篇 |
1986年 | 59篇 |
1985年 | 64篇 |
1984年 | 50篇 |
1983年 | 43篇 |
1980年 | 36篇 |
1979年 | 37篇 |
1978年 | 30篇 |
1977年 | 30篇 |
1975年 | 37篇 |
1974年 | 38篇 |
1973年 | 23篇 |
1972年 | 25篇 |
1971年 | 26篇 |
1970年 | 31篇 |
1969年 | 19篇 |
Background
Multiple myeloma (MM) is a hematologic malignancy of plasma cell origin. MM primarily affects bone marrow, but extramedullary sites can also be involved. Myelomatous pleural effusion (MPE) is an atypical and rare complication of MM. We aimed to systematically study the incidence and clinicopathologic profile of patients with MPE in a real-world setting.Patients and Methods
In this retrospective study, 415 consecutive patients with MM managed at a tertiary care center in North India during a study period of January 1, 2010 to December 31, 2015 were evaluated for MPE. The patients with MPE were analyzed for their clinical profile, diagnosis, treatment, and outcomes.Results
Of these 415 patients, 11 (2.65%) patients had MPE. The median age of the study population was 50 years with male preponderance. The majority of these patients had immunoglobin (Ig)G Kappa disease. All patients had higher than International Staging System stage I disease. MPE was a presenting feature at MM diagnosis in 45.45% (n = 5) of the patients, whereas the rest developed MPE during follow-up. MPE presented predominantly (81.8%) as a unilateral effusion. Concurrent extramedullary involvement at other site was seen in 45.45% (n = 5), with 3 (27%) patients having concurrent myelomatous ascites. Six of these were managed aggressively, whereas 5 patients opted for palliation. The outcomes were dismal (90.9% mortality), with a median survival of 2.47 months.Conclusion
MPE is a rare entity, and positive outcomes of therapy remain low with dismal prognosis. 相似文献2. IB did not show a gender difference in the mediofrontal area. However, women had higher IB in the right orbital frontal cortex than did men.
3. In vivo pharmaco-EEG results tend to support the postmortem neurochemical data. Intravenous chlorimipramine resulted in an asymmetric topographic distribution of the P300 auditory evoked potential, peak amplitudes were shifted to the right hemisphere. 相似文献
In 51 subjects who had discontinued NET EN due to amenorrhoea, the return of fertility was predictably slower and less. The return of fertility in subjects who discontinued NET EN for other reasons (e.g. excessive bleeding and other personal reasons) was similar to ex-NET EN and ex-CuT 200 users. 相似文献