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1.
Management of post-tuberculous complex aspergilloma of the lung: role of surgical resection. 下载免费PDF全文
S A al-Majed M Ashour F A el-Kassimi I Joharjy A al-Wazzan M S al-Hajjaj R Vijay 《Thorax》1990,45(11):846-849
Of 14 patients with complex aspergilloma complicating healed tuberculosis, 12 underwent lobectomy or pneumonectomy for recurrent haemoptysis. No deaths occurred, though one patient needed re-exploration for bleeding. There was no postoperative worsening of dyspnoea despite a mean forced vital capacity (FVC) of 60% predicted for the patients undergoing surgery and of 20% predicted for two patients with severe restrictive defects, perhaps owing to the fact that there was little or no function in the resected part of the lung, as shown by preoperative isotope ventilation-perfusion scanning, and that patients were under the age of 50 and generally fit. There has been no recurrence of haemoptysis during follow up, which has been from 12 to 33 months. Surgical resection, provided that cases are carefully selected, offers the best chance of cure with low mortality and morbidity. 相似文献
2.
PCR analysis of egyptian respiratory adenovirus isolates, including identification of species, serotypes, and coinfections 下载免费PDF全文
Metzgar D Osuna M Yingst S Rakha M Earhart K Elyan D Esmat H Saad MD Kajon A Wu J Gray GC Ryan MA Russell KL 《Journal of clinical microbiology》2005,43(11):5743-5752
Eighty-eight adenovirus (Ad) isolates and associated clinical data were collected from walk-in patients with influenza-like illness in Egypt during routine influenza surveillance from 1999 through 2002. Respiratory Ad distributions are geographically variable, and serotype prevalence has not been previously characterized in this region. Serotype identity is clinically relevant because it predicts vaccine efficacy and correlates strongly with both clinical presentation and epidemiological pattern. Species and serotype identities were determined using several well-validated multiplex PCR protocols culled from the literature and supplemented with a few novel primer sets designed to identify rare types. The isolates included common species B1 serotypes (Ad3 and Ad7), common species C serotypes (Ad1, Ad2, and Ad5), the less common species B2 serotype Ad11, and three isolates of the rare species B1 serotype Ad16. Two isolates that appear to be variant Ad16 were also identified. Fifteen coinfections of multiple adenoviral types, primarily AdB/AdC and Ad3/Ad7 dual infections, were detected. The majority of these were verified using redundant PCR tests targeted at multiple genes. PCR is able to resolve coinfections, in contrast to traditional serum neutralization tests. PCR is also comparatively rapid and requires very little equipment. Application of the method allowed an inclusive determination of the serotypes found in the Egyptian respiratory sample set and demonstrated that coinfections are common and may play a previously unrecognized role in adenovirus pathogenesis, evolution, and epidemiology. In particular, coinfections may influence adenoviral evolution, as interserotypic recombination has been identified as a source of emerging strains. 相似文献
3.
Fahim FA Esmat AY Fadel HM Hassan KF 《International journal of food sciences and nutrition》1999,50(6):413-427
The hepatoprotective and antimutagenic effects of the rosemary essential oil and the ethanolic extract were investigated using carbon tetrachloride and cyclophosphamide as hepatotoxic and mutagenic compounds, respectively. Our results revealed that i.g. administration of the rosemary ethanolic extract (0.15 g/100 g BW) to rats for 3 weeks produced the most pronounced hepatoprotective effect compared to silymarin (reference compound) due to the amelioration of most of the studied serum and liver parameters and confirmed by histopathological examination of the liver tissue. Pretreatment of mice for 7 days with the rosemary essential oil (1.1 mg/g BW) followed by i.p. injection with cyclophosphamide reduced significantly the induced mitodepression in the bone marrow cells of the animals. The potential hepatoprotective and antimutagenic activities of the rosemary ethanolic extract and essential oil, respectively, are attributed to the presence of a relatively high percentage of phenolic compounds with high antioxidant activity (according to our chemical studies). 相似文献
4.
A.A. Ashour M. Zaghloul W. Mahmoud M.E. Helal M.E. Grawish 《International journal of oral and maxillofacial surgery》2018,47(11):1488-1494
This study evaluated the effect of Gelfoam sponge with and without autologous bone marrow-derived stem cells (BMSCs) on bone regeneration in critical-size mandibular defects. The study involved 56 New Zealand rabbits assigned to four groups (14 in each). The osseous defects in group I were irrigated with normal saline, those in group II were grafted with autogenous tibial bone, and those in group III were filled with Gelfoam sponge. Group IV defects were treated as for group III, but the interface between the Gelfoam sponge and bone surface was injected with BMSCs. At the end of 4 weeks, seven rabbits in each group were euthanized; the remaining animals were euthanized at the end of the experiment, at 8 weeks postoperative. The percentage area of newly formed bone was significantly higher in group IV at week 4 (0.030 ± 0.01%) and week 8 (0.060 ± 0.03%) than in group I (0.01 ± 0.00% and 0.02 ± 0.00%, respectively) and group III (0.08 ± 0.01% and 0.015 ± 0.02%, respectively), but was lower than that in group II (0.038 ± 0.02% and 0.082 ± 0.01%, respectively). Thus, the combination of Gelfoam and autologous BMSCs promoted the regeneration of mandibular critical-size defects better than the use of Gelfoam alone. However, the amount of newly generated bone was lower than in defects grafted with autogenous bone. 相似文献
5.
Iris?Iglesia Isabelle?Guelinckx Pilar?M.?De?Miguel-Etayo Esther?M.?González-Gil Jordi?Salas-Salvadó Stavros?A.?Kavouras Joan?Gandy Homero?Martínez Saptawati?Bardosono Morteza?Abdollahi Esmat?Nasseri Agnieszka?Jarosz Guansheng?Ma Esteban?Carmuega Isabelle?Thiébaut Luis?A.?MorenoEmail author 《European journal of nutrition》2015,54(2):57-67
Purpose
To describe total fluid intake (TFI) according to socio-demographic characteristics in children and adolescents worldwide.Methods
Data of 3611 children (4–9 years) and 8109 adolescents (10–18 years) were retrieved from 13 cross-sectional surveys (47 % males). In three countries, school classes were randomly recruited with stratified cluster sampling design. In the other countries, participants were randomly recruited based on a quota method. TFI (drinking water and beverages of all kinds) was obtained with a fluid-specific record over 7 consecutive days. Adequacy was assessed by comparing TFI to 80 % of adequate intake (AI) for total water intake set by European Food Safety Authority. Data on height, weight and socio-economic level were collected in most countries.Results
The mean (SD) TFI ranged from [1.32 (0.68)] to [1.35 (0.71)] L/day. Non-adherence to AIs for fluids ranged from 10 % (Uruguay) to >90 % (Belgium). Females were more likely to meet the AIs for fluids than males (4–9 years: 28 %, OR 0.72, p = 0.002; 10–18 years: 20 %, OR 0.80, p = 0.001), while adolescents were less likely to meet the AI than children (OR 1.645, p < 0.001 in males and OR 1.625, p < 0.001 in females).Conclusions
A high proportion of children and adolescents are at risk of an inadequate fluid intake. This risk is especially high in males and adolescents when compared with females or children categories. This highlights water intake among young populations as an issue of global concern.6.
7.
Efficacy of different modes of fractional CO2 laser in the treatment of primary cutaneous amyloidosis: A randomized clinical trial 下载免费PDF全文
Samia M. Esmat MD Marwa M. Fawzi MD Heba I. Gawdat MD Heba S. Ali Safinaz S. Sayed MD 《Lasers in surgery and medicine》2015,47(5):388-395
Background
Primary cutaneous amyloidosis (PCA) comprises three main forms: macular, lichen, and nodular amyloidosis. The current available treatments are quite disappointing.Objectives
Assess and compare the clinical and histological changes induced by different modes of Fractional CO2 laser in treatment of PCA.Patients and Methods
Twenty five patients with PCA (16 macular and 9 lichen amyloidosis) were treated by fractional CO2 using; superficial ablation (area A ) and deep rejuvenation (area B ). Each patient received 4 sessions with 4 weeks intervals. Skin biopsies were obtained from all patients at baseline and one month after the last session. Patients were assessed clinically and histologically (Congo red staining, polarized light). Patients were followed‐up for 3 months after treatment.Results
Both modes yielded significant reduction of pigmentation, thickness, itching, and amyloid deposits (P‐value < 0.001). However, the percentage of reduction of pigmentation was significantly higher in area A (P‐value = 0.003). Pain was significantly higher in area B. Significant reduction in dermal amyloid deposits denotes their trans‐epidermal elimination induced by fractional photothermolysis.Conclusion
Both superficial and deep modes of fractional CO2 laser showed comparable efficacy in treatment of PCA. Superficial mode being better tolerated by patients, is recommended as a valid therapeutic option. Lasers Surg. Med. 47:388–395, 2015. © 2015 Wiley Periodicals, Inc. 相似文献8.
Majdi Ashour 《Lancet》2018
Background
Catastrophic health expenditure (CHE) is measured to assess the financial protection from the risk of health-related conditions, which is considered a principle performance goal of any health system. The incidence and intensity of CHE in the occupied Palestinian territory between 1998 and 2007 was assessed in previous research; however, no research has assessed the occurrence of CHE in different population groups in the occupied Palestinian territory. The objective of this study was to examine the changes in the occurrence of CHE in different groups of Palestinians from 1996 to 2011, which was a period of increasing political turmoil, transformation of the national health system, and economic hardship faced by the population.Methods
The repeated cross-sectional series of the Palestinian Expenditure and Consumption Survey was conducted by the Palestinian Central Bureau of Statistics ten times between 1996 and 2011. Each survey asks detailed questions about a household's expenditure, including spending on health, using a diary approach. CHE was measured using a threshold of spending of 10% or more of the household's resources on health care. Total household expenditure was used as a proxy of a household's resources. The occurrence of CHE was traced from 1996 to 2011 and compared across different expenditure quantiles, dwellers of urban areas, rural areas, or refugee camps, and the characteristics of head of households within the West Bank and the Gaza Strip were compared.Findings
CHE in the occupied Palestinian territory increased from 7·3% of households in 1996 to 8·2% of households in 2011. This increase was observed in the West Bank and Gaza Strip. However, the occurrence of CHE in the Gaza Strip was consistently and significantly lower than in the West Bank. CHE was consistently higher in the worse-off expenditure quantiles in the occupied Palestinian territory and in the West Bank compared with affluent households. The change in the occurrence of CHE in different expenditure quantiles in the Gaza Strip was statistically insignificant from 1997 to 2004. From 2005 onward, the economically vulnerable groups of the households have become less exposed to CHE than affluent households. The occurrence of CHE in households in rural areas of the West Bank was consistently higher than elsewhere. Households in the West Bank with illiterate heads of family were consistently more exposed to CHE than other households, whereas the opposite was observed in the Gaza Strip.Interpretation
The findings should be interpreted within the context of the unique Palestinian situation. For example, the overburdened rural populations in the West Bank could have greater difficulty in accessing health services. The lower occurrence of CHE in the Gaza Strip and the trend towards reducing inequalities between the more vulnerable households, especially in a period of socioeconomic adversity, points to an emerging paradox of resilience in the Gaza Strip, which should be investigated carefully from the perspectives of both the health system and social lives.Funding
None. 相似文献9.
Khairy MA Zoheir Ahmed A Abd-Rabou Gamaleldin I Harisa Abdelkader E Ashour Sheikh Fayaz Ahmad Sabry M Attia Saleh A Bakheet Hala E Abdel-Hamied Adel R Abd-Allah Ashok Kumar 《International journal of clinical and experimental pathology》2015,8(8):8821-8831
IQGAPs genes play critical role in either induction or suppression of cancer and its progression, however the relationship between Ras genes and these genes are still unclear. In this study, we tried to understand the mechanistic action of IQGAPs genes and its correlation with Ras genes in mouse hepatic cancer model. The genetic expressions of IQGAP1, IQGAP2, IQGAP3, Hras, Kras, Nras, Mras, Caspase3, and BAX were followed in both hepatocellular carcinoma and normal liver cells of Balbc mice. Genotoxic agent diethylnitrosamine (DEN)-induced hepatic cancer model was induced in male mice and recorded the occurrence of hepatocellular carcinoma by morphological and histological changes in the liver. It was observed that mRNA expressions of IQGAP1, Hras, Kras, Nras, Mras, Caspase3, and BAX genes were highly elevated in hepatocellular carcinoma cells when compared with normal liver cells, additionally their expressions increased by concentrating the dose of DEN. While, the expressions of IQGAP2 and IQGAP3 were significantly decreased in hepatocellular carcinoma cells when compared with normal liver cells, as well as their expressions decreased more with increasing the dose of DEN. It was concluded from this study that IQGAP1 has a strong signaling relationship with Ras genes in induction of cancer and it is considered as a key gene for induction or suppression of the hepatocellular carcinoma. 相似文献
10.
Clinical and molecular characterization of seven Egyptian families with autosomal recessive robinow syndrome: Identification of four novel ROR2 gene mutations 下载免费PDF全文