全文获取类型
收费全文 | 7085篇 |
免费 | 421篇 |
国内免费 | 42篇 |
专业分类
耳鼻咽喉 | 124篇 |
儿科学 | 250篇 |
妇产科学 | 348篇 |
基础医学 | 724篇 |
口腔科学 | 313篇 |
临床医学 | 592篇 |
内科学 | 1419篇 |
皮肤病学 | 103篇 |
神经病学 | 426篇 |
特种医学 | 203篇 |
外国民族医学 | 7篇 |
外科学 | 1229篇 |
综合类 | 167篇 |
一般理论 | 2篇 |
预防医学 | 554篇 |
眼科学 | 153篇 |
药学 | 560篇 |
中国医学 | 51篇 |
肿瘤学 | 323篇 |
出版年
2023年 | 59篇 |
2022年 | 78篇 |
2021年 | 253篇 |
2020年 | 186篇 |
2019年 | 229篇 |
2018年 | 288篇 |
2017年 | 196篇 |
2016年 | 219篇 |
2015年 | 253篇 |
2014年 | 297篇 |
2013年 | 389篇 |
2012年 | 571篇 |
2011年 | 516篇 |
2010年 | 330篇 |
2009年 | 288篇 |
2008年 | 391篇 |
2007年 | 414篇 |
2006年 | 405篇 |
2005年 | 390篇 |
2004年 | 295篇 |
2003年 | 285篇 |
2002年 | 223篇 |
2001年 | 89篇 |
2000年 | 79篇 |
1999年 | 73篇 |
1998年 | 44篇 |
1997年 | 30篇 |
1996年 | 34篇 |
1995年 | 26篇 |
1994年 | 24篇 |
1993年 | 21篇 |
1992年 | 39篇 |
1991年 | 45篇 |
1990年 | 46篇 |
1989年 | 39篇 |
1988年 | 39篇 |
1987年 | 45篇 |
1986年 | 31篇 |
1985年 | 26篇 |
1984年 | 20篇 |
1983年 | 22篇 |
1980年 | 12篇 |
1979年 | 13篇 |
1978年 | 14篇 |
1977年 | 18篇 |
1974年 | 15篇 |
1973年 | 18篇 |
1972年 | 17篇 |
1970年 | 17篇 |
1969年 | 18篇 |
排序方式: 共有7548条查询结果,搜索用时 31 毫秒
1.
Correction to: Macular microvascular changes in children with transfusion-dependent beta-thalassemia
AttaAllah Heba Radi Mousa Suzan Omar Omar Ismail Ahmed Nagib 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2022,260(4):1431-1431
Graefe's Archive for Clinical and Experimental Ophthalmology - 相似文献
2.
3.
4.
Sabin J. Bozso Jeevan Nagendran Roderick G.G. MacArthur Michael W.A. Chu Bob Kiaii Ismail El-Hamamsy Raymond Cartier Ali Shahriari Michael C. Moon 《The Journal of thoracic and cardiovascular surgery》2019,157(5):1763-1771
Objectives
We describe the Canadian results of the Ascyrus Medical Dissection Stent (AMDS), a novel partially uncovered aortic arch hybrid graft implanted antegrade during hypothermic circulatory arrest to promote true lumen expansion and enhance aortic remodeling.Methods
From March 2017 to February 2018, 16 consecutive patients (66 ± 12 years; 38% female) presented with acute type A aortic dissections and underwent emergent surgical aortic repair with AMDS implantation. All patients presented with DeBakey I aortic dissection, with evidence of malperfusion in 50% (n = 8) of patients. All cases were performed under hypothermic circulatory arrest with an additional average duration for AMDS implantation time of 2.1 minutes.Results
All 16 device implantations were successful. Overall 30-day mortality was 6.3% (n = 1) and stroke occurred in 6.3% (n = 1) of cases. There was no incidence of device-related aortic injury or aortic arch branch vessel occlusion. During the follow-up period, 12 patients had completed at least 1 postoperative computed tomography scan. At initial follow-up computed tomography scan, complete or partial thrombosis, and remodeling of the aortic arch occurred in 91.7% of cases (n = 11/12) and in the proximal descending thoracic aorta, complete or partial thrombosis, and remodeling occurred in 91.7% (n = 11/12).Conclusions
Preliminary results suggest that the AMDS is a safe, feasible and reproducible adjunct to current surgical approaches for acute DeBakey I aortic dissection repair. Further, the AMDS manages malperfusion and promotes early positive remodeling in the aortic arch and distal dissected segments, with favorable FL closure rates at follow-up. Ongoing follow-up will provide additional insight into the long-term effects of the AMDS. 相似文献5.
Samira Marín-Romero Teresa Elías-Hernández María Isabel Asensio-Cruz Rocío Ortega-Rivera Raquel Morillo-Guerrero Javier Toral Emilio Montero Verónica Sánchez Elena Arellano José María Sánchez-Díaz Macarena Real-Domínguez Remedios Otero-Candelera Luis Jara-Palomares 《Archivos de bronconeumología》2019,55(12):619-626
IntroductionScales for predicting venous thromboembolism (VTE) recurrence are useful for deciding the duration of the anticoagulant treatment. Although there are several scales, the most appropriate for our setting has not been identified. For this reason, we aimed to validate the DASH prediction score and the Vienna nomogram at 12 months.MethodsThis was a retrospective study of unselected consecutive VTE patients seen between 2006 and 2014. We compared the ability of the DASH score and the Vienna nomogram to predict recurrences of VTE. The validation was performed by stratifying patients as low-risk or high-risk, according to each scale (discrimination) and comparing the observed recurrence with the expected rate (calibration).ResultsOf 353 patients evaluated, 195 were analyzed, with an average age of 53.5 ± 19 years. There were 21 recurrences in 1 year (10.8%, 95% CI: 6.8%-16%). According to the DASH score, 42% were classified as low risk, and the rate of VTE recurrence in this group was 4.9% (95% CI: 1.3%-12%) vs. the high-risk group that was 15% (95% CI: 9%-23%) (p <.05). According to the Vienna nomogram, 30% were classified as low risk, and the rate of VTE recurrence in the low risk group vs. the high risk group was 4.2% (95% CI:0.5%-14%) vs. 16.2% (95% CI: 9.9%-24.4%) (p <.05).ConclusionsOur study validates the DASH score and the Vienna nomogram in our population. The DASH prediction score may be the most advisable, both because of its simplicity and its ability to identify more low-risk patients than the Vienna nomogram (42% vs. 30%). 相似文献
6.
7.
8.
Ismail O. Ishola Onyinyechi E. Akataobi Azeez A. Alade Olufunmilayo O. Adeyemi 《Fundamental & clinical pharmacology》2019,33(3):277-285
There is a growing number of epidemiological and molecular studies which suggest that diabetes is associated with an increased risk of Parkinson's disease (PD). Hence, in this study, the effect of glimepiride (GPD), a sulphonylurea (antidiabetic) on paraquat (PQT)‐induced Parkinsonism was evaluated in mice. Thirty‐six mice were randomly divided into six groups (n = 6) and treated orally for 21 consecutive days as follows: Group 1: vehicle (10 mL/kg), Group 2: PQT (10 mg/kg, i.p., twice per week for 3 weeks), Group 3–5: GPD (1, 2 or 4 mg/kg) + PQT (10 mg/kg, i.p., twice per week for 3 weeks), Group 6: GPD (4 mg/kg, p.o.). The effects of the treatment on motor coordination were evaluated using the rotarod performance, bar and open field tests while working memory was assayed using Y‐maze test. Paraquat injection induced significant decrease in falling time, number of crosses and percentage alternation behaviour with a concomitant increase in the duration of cataleptic behaviour in the rotarod, open field, Y‐maze and bar tests, respectively, which was ameliorated by GPD treatment. PQT also increased lipid peroxidation, peroxynitrite and TNF‐α generations as well as deficit in superoxide dismutase and GSH activities in the midbrain. PQT‐induced oxidative stress and neuroinflammation was attenuated by GPD treatment. Findings from this study showed that GPD prevents PQT‐induced motor dysfunction, memory impairment, oxidative stress and neuroinflammation through enhancement of antioxidant defense system and inhibition of pro‐inflammatory cytokine release. Thus, GPD could be a potential adjunct in the management of Parkinsonism. 相似文献
9.
Diagnosis of the multiple effect of selenium nanoparticles decorated by Asteriscus graveolens components in inhibiting HepG2 cell proliferation 总被引:1,自引:0,他引:1
Samie Yaseen Sharaf Zeebaree Aymn Yaseen Sharaf Zeebaree Osama Ismail Haji Zebari 《Sustainable Chemistry and Pharmacy》2020
Using plant bio-components for Designing green metal nanoparticles was considered as one of the most important methods in nanomedical application field due to their eco-friendly, cheap source, easily obtainable and having a high detection result. In this report, we fabricated eco-friendly engineering and cost-effective technique for green selenium nanoparticles from 0.01 M H2SeO3 solution using Asteriscus graveolens leaves extract as reducing and a capping agent at ambient temperature. Spectral techniques have been used to identify the formatted Selenium nanoparticles such as UV–Vis, pH, XPs, FT-IR, XRD, LDS, Z.P, EDS, TEM and AFM spectroscopy, which showed a size of 20 nm with spherical shape. Herein, the multi-effect of decorated Se-NPs surface have been evaluated, firstly on the hemolysis that showed completely hemocompatibility. Cytotoxicity assay showed that Se-NPs have a high selective effect on the HepG2 apoptosis and which proved by phase-contrast microscopy. Furthermore, the effect of nanoparticles on the action of the mechanism internal revealed that Se-NPs significantly and rapidly increased the level of reactive oxygen species and lipid peroxidation, while caused decreased the potential of mitochondrial membrane and glutathione level, which they together responsible on regulating the HepG2 cells fate. Furthermore, Flow cytometry analysis gave high values about S and G2/M phases of cell cycle resulting from Se-NPs effectiveness. In the end, with all the recorded information that has been measured in this study, this report provides a suitable and effective pathway for the green fabrication of Se-NPs decorated by biomolecules having high anticancer inhibited. 相似文献
10.