血清 cf-DNA 定量分析在宫颈癌早期辅助诊断及预后判断中的价值

文章对宫颈癌、CINⅢ及健康妇女行血清cf-DNA定量检测，探讨血清cf-DNA定量分析诊断技术在宫颈癌的早期诊断及判断宫颈癌预后的辅助作用。结果显示，宫颈癌患者血清cf-DNA含量显著高于CINⅢ患者和健康妇女，Ⅱ、Ⅲ期宫颈癌患者血清cf-DNA含量明显高于Ⅰ期患者；血清cf-DNA对于宫颈癌诊断的敏感性和特异性均高于传统肿瘤标志物。     

关节松动术治疗肩周炎的综合评定

目的　探讨关节松动术对肩周炎的疗效。方法　采用肩关节松动术治疗肩周炎 3 2例 ,同时用肩关节功能评价量表在治疗前后对肩关节疼痛、ROM、ADL、肌力及局部形态进行综合评定。结果　治愈 8例 ,显效 13例 ,好转 9例 ,无效 2例 ,有效率 93 .75 %;治疗后肩关节功能评定得分显著增加 (P <0 .0 0 1) ;以治疗后肩关节功能分值、治疗前后得分增加值为标准评定疗效并与临床疗效评定结果比较 ,差异无显着性 (P >0 .0 5 )。结论　关节松动术对肩周炎具有显着疗效 ,肩关节功能评价量表可作为肩周炎的康复评定     

周围性面神经麻痹的综合治疗(附335例临床分析)

<正> 周围性面神经麻痹一种常见多发病。我科选用了超短波、TDP和自我手法按摩,依据病情需要,部分患者加用药物等综合治疗,取得了满意的效果,现讨论分析如下: 资料和方法本组周围性面神经麻痹335例,男204例,女131例;年龄5～20岁24例,<30岁119例,<40岁65例,<50岁55例,>50岁72例;病程最短的半天,最长的5个月,大部分病人由神经内科转来,根据病史,病人耳内、乳突区、下颌角周围轻度疼痛;面部表情肌瘫痪,不能皱额,蹙口角下垂,并被牵向健侧;不能鼓腮,吹哨等症状,诊断不难。     

慢性腹泻临证举隅

慢性腹泻证系临床常见之病症,其病位虽在脾胃,但与肝肾功能失常有关,常以脾肾阳虚,肝气乘者多见.脾为后天之本,主运化,但赖肾阳之温煦.肾阳不足易致脾阳失温,运化失司;脾阳不振运化不能,精微不充,气血化源不足,致精血亏损,久虚及肾,从而导致脾肾双虚,运化更失常态清浊相挟而生泄泻.临证可见大便时溏时泻,完谷不化,或五更肠鸣作泻,日久不愈反复发作.可伴脘腹不适或冷痛,食纳减少,或食后脘痞不舒,神疲乏力,肢寒畏冷,面色不泽,舌淡苔白脉沉缓少力.     

糖尿病并发低血钾63例原因分析

本文对63例糖尿病并发低血钾患者的治疗，发现良好的控制血糖、合并症，使血钾浓度的改变有统计学意义。初步分析糖尿病并发低血钾原因，现报道如下：     

肺型白塞氏病并发呼吸窘迫综合征一例报告

患者,女性,35岁。因反复口、眼溃疡3年,伴发热、关节痛3月,有自愈倾向。在外院行皮肤活检、病理诊断为白塞氏病,不完全型。予以皮质激素治疗,溃疡愈合。1989年7月初出现阵发性呼吸紧促,口唇发绀,心悸,胸闷,于1989年7月17日收入院。既往无心肺病史。查体:体温38℃,脉搏128次/分,呼吸46次/分,血压12/8kPa,呼吸急促,口唇发绀,皮肤、巩膜无黄染、出血点及皮疹,表浅淋巴结未触及、口腔粘膜无溃疡,甲状腺不肿大、颈静脉不怒张,气管居中,胸廓无畸形,呼吸动度对称,无三凹征,胸部叩诊呈清音,两肺呼吸音粗,无干湿鸣,心界不大,心率128次/分,未闻及病理性杂音。化验:血红蛋白121g/L,白细胞4.2×10~9/L,中性71％,淋巴28％,单核1％,血沉44mm/h、抗0 1:400,类风湿因子阴性。     

Parkin基因启动子区-258T/G多态性与广西地区散发性帕金森病的相关性分析

Objective To investigate the association between the-258T/G polymorphism.in the pro-moter of parkin gene and the risk for sporadic parkinson's disease (SPD) in Guangxi Province, and in relationto the age of onset, of PD patients. Methods PCR-RFLP and sequence analysis were used to determine thegenotype of-258T/G polymorphism between all patients and healthy controls. Results The G allele was morecommon in patients than controls (55.20%:43.33% ,x2=6.898, P<0.05, OR=1.61, 95% CI: 1.13 ～2.30). The frequency of GG genotype was higher in patients than in controls (28.00 %: 18.33%, x2=7.159, P<0.05, OR=2.75, 95% CI : 1.31 ～ 5.77). The frequency of TG + GG genotype was higher in pa-tients than in controls (82.40%:68.33%, x2=6.551, P<0.05, OR=2.17.95%CI: 1.20 ～3.93). Afterbeing stratified by onset age, the frequencies of the G allele and GG genotype were significantly higher in pa-tients with onset age over 50 years than those in controls respectively. On the other hand, the frequency was notsignificantly different between the younger onset PD patients and the controls. Conclusion The parkin promot-er-258T/G polymorphism might be a risk factor for PD in Guangxi Province, and the G allele was increasedwith increasing age.     

Parkin基因启动子区-258T/G多态性与广西地区散发性帕金森病的相关性分析

Objective To investigate the association between the-258T/G polymorphism.in the pro-moter of parkin gene and the risk for sporadic parkinson's disease (SPD) in Guangxi Province, and in relationto the age of onset, of PD patients. Methods PCR-RFLP and sequence analysis were used to determine thegenotype of-258T/G polymorphism between all patients and healthy controls. Results The G allele was morecommon in patients than controls (55.20%:43.33% ,x2=6.898, P<0.05, OR=1.61, 95% CI: 1.13 ～2.30). The frequency of GG genotype was higher in patients than in controls (28.00 %: 18.33%, x2=7.159, P<0.05, OR=2.75, 95% CI : 1.31 ～ 5.77). The frequency of TG + GG genotype was higher in pa-tients than in controls (82.40%:68.33%, x2=6.551, P<0.05, OR=2.17.95%CI: 1.20 ～3.93). Afterbeing stratified by onset age, the frequencies of the G allele and GG genotype were significantly higher in pa-tients with onset age over 50 years than those in controls respectively. On the other hand, the frequency was notsignificantly different between the younger onset PD patients and the controls. Conclusion The parkin promot-er-258T/G polymorphism might be a risk factor for PD in Guangxi Province, and the G allele was increasedwith increasing age.