内脏脂肪指数与冠状动脉慢血流相关性分析

目的 探讨内脏脂肪指数(visceral adiposity index,VAI)与冠状动脉慢血流现象(coronary slowflow phenomenon,CSFP)的相关性,分析CSFP的病理生理特征。方法 选取2021年1月至2022年12月在东营市人民医院行冠状动脉造影显示心外膜冠状动脉无明显病变的慢血流患者75例,为CSFP组;另选取同期因心脏症状行冠状动脉造影显示冠状动脉正常的患者65例,为正常组。测量两组患者身高、体质量、腰围(WC)等一般资料,并采集血液,检测总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇(HDL-C)、三酰甘油、空腹血糖等指标。结果 CSFP组和正常组体质量指数[(27.65±2.90) kg/m² vs (23.99±2.3) kg/m²,P<0.001]、WC[(94.25±11.65)cm vs (83.20±5.7)cm,P<0.001]、高血压病(66.7%vs 41.5%,P=0.003)、吸烟(38.7%vs 12.3%,P<0.001)、三酰甘油[(2.49±1.04)...     

Changes of insulin resistance and plasma levels of Ang Ⅱ and NO in normal offspring with a family history of es sential hypertension

Backgound Essential hypertension (EH) is a polygenic inheritable disease,generally known as a combined result of genetic and environmental elements.It is possible that IR、AngiotensinⅡ(AngⅡ) and NO play important roles in the pathogenesis of EH.Methods Sixty normal subjects with a family history of EH,aged 30 to 40 years old,were recruited and randomized into two groups:30 with one parent and 30 with both parents with EH,and 30 subjects without family history of EH as controls.The plasma level of NO was determined by electrophotometer while the plasma level of fast insulin (FINS) and AngⅡ were determined by radioimmuno-assay,and insulin resistance index (IRI) was calculated.Results ① The plasma levels of FINS,AngⅡ,NO increased significantly in study groups compared with those in the control group(P < 0.01),while there were no differences in the levels of AngII,NO between the two study groups (P > 0.05).② The plasma level of AngII were positively correlated with that of NO(r=0.378,P < 0.01).Conclusions The higher levels of IR and plasma AngII and NO exist before the development of EH in normal offspring with a family history of EH,and maybe they are initial agents in the pathogenesis of EH.It indicates that the people with IR and high levels of plasma AngⅡand NO with a family history of EH are at higher risk to develop EH.     

心房颤动和认知功能下降的关系研究

心房颤动（简称房颤）是老年人常见的心律失常,并随着年龄增长发病率及死亡率增高。众多的血管危险因素和血管疾病导致认知功能障碍和痴呆,而年龄亦是认知功能障碍的最主要因素。房颤和认知功能障碍相关的可能机制有：共同危险因素及共患病、缺血性卒中（有症状或无症状）、房颤的促炎状态等。房颤患者窦律的恢复和抗凝治疗有可能降低认知功能障碍的发生。本文将从房颤与认知功能障碍的相关性、可能机制及房颤治疗后认知获益方面进行综述。     

中老年心房颤动患者轻度认知功能障碍的影响因素分析

目的：分析中老年非瓣膜性心房颤动（Atrial Fibrillation）患者轻度认知功能障碍（Mild Cognitive Impairment）的状况及其影响因素。方法：纳入自2019年10月至2020年6月就诊于应急总医院心内科及干部医疗科的非瓣膜性心房颤动患者106例,完成记忆、注意、语言、执行、视空间功能五大认知域的神经精神量表的筛查,分为轻度认知功能障碍组和认知功能正常组。采用多因素logistic分析探讨非瓣膜性心房颤动患者轻度认知功能障碍的影响因素。结果：106例患者中有58例为轻度认知功能障碍,平均年龄63岁,MCI组的房颤类型（持续/永久房颤）（P=0.017）、高血压病史比例（P=0.002）,CHA2DS2-VASc评分（P=0.047）,左房前后径（P=0.038）较正常认知组高,血红蛋白在MCI组偏低（P=0.034）,logistic回归分析发现非瓣膜性房颤人群的认知功能障碍与房颤类型、高血压、糖尿病病史、血红蛋白量相关。结论：房颤和认知功能障碍的发生都随着年龄增大而增加,房颤患者的发病类型、高血压、糖尿病病史和血红蛋白水平是发生轻度认知功能障碍的危险因素,早期识别轻度认知功能障碍对缓解认知进一步下降至关重要。     

钙激活氯通道蛋白TMEM16A在小鼠心肌组织的表达

目的探讨钙激活氯通道蛋白TMEM16A在小鼠心肌组织的表达。方法采用RT-PCR和免疫荧光染色方法,检测小鼠心肌组织中TMEM16A的表达。结果小鼠心肌组织中检测到TMEM16A mRNA和蛋白的表达。结论小鼠心肌存在TMEM16A通道蛋白。