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端粒是真核生物染色体的物理末端结构 ,由富含 G的寡核苷酸 DNA重复序列组成[1 ] 。人类染色体端粒平均长度为 8~14kb,核心序列是 5′TTAGGG3′[2 ,3 ] 。它和相邻的端粒结合蛋白一起具有维持染色体稳定的功能 [4] 。研究表明 ,在结肠癌、Wilms癌、乳腺癌等实体瘤及慢性粒细胞白血病中端粒长度明显缩短 [5 ] ,提示端粒长度异常与癌变之间可能存在一定相关性。我们对人肺癌染色体端粒行为异常与癌变的关系进行了一些探讨。1 对象和方法1.1 对象 人肺癌组织和癌旁组织标本来源于华西医科大学附属第一医院胸心外科病理诊断为肺癌的术… 相似文献
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Telomere is the tenonal sthetUxe of the chtDInosomes Of eukaryote and it consists of repeated seqUences ofoligonucledde wb rich G[IJ. In hUInan being, the avemp length of telomere is 8 -- 14 kb and its core sc.thence is 5' mGGG3I[2'3]. Telomere and its binding...Pmtein ~ntam the stability of .hmmosome.[']. odiousstudies reported that telomere length was obviously shortened in Patients with chIDnic myeloid leukenda and solidc~inomas such as colon c~inolna and ~ c~inomalsJ. There aught b… 相似文献
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目的:比较门诊美容外科手术使用咪达唑仑或异丙酚辅助局麻的效果.方法:对我院2000年1月~2003年1 2月门诊美容手术病人使用咪达唑仑或异丙酚辅助局麻的效果进行分析总结,用Ramsay评分评估镇静分级,同时监测HR、SPO2、SBP、DBP、MBP、顺行性遗忘和并发症发生情况.结果:两组病人用药后均很快入睡(P>0.05),用药后5min、1 0min、1 5min监测HR、SPO2、SBP、DBP、MBP稍有波动,但在正常范围,少数病人术后出现轻微恶心,咪达唑仑组顺行性遗忘率(85.7%)明显高于异丙酚组(42.2%)(P<0.05).结论:门诊美容外科手术使用小剂量咪达唑仑或异丙酚安全有效,与异丙酚相比,咪达唑仑具有良好的顺行性遗忘作用. 相似文献
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甲亢患者阴虚阳亢病机与头发微量元素变化关系之初探 总被引:2,自引:0,他引:2
本实验通过20例甲亢“阴虚阳亢”证患者与36例正常人比较,发现甲亢“阴虚阳亢”患者头发中的微量元素与正常人之间存在显著差异,为中医辨证客观化和研究甲亢之病机提供了新依据。 相似文献
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Rats were randomly divided into threegroups:control,carbon tetrachloride(CCl_(/4)),andcarbon tetrachloride plus electroacupuncture(EA).The concentrations of 5-hydroxytrypta-mine(5-HT),5-hydroxyindoleacetic acid(5-HIAA),noradrenaline(NA)and dopamine(DA)were determined by spectrophoto-fluoremetry insix different brain regions(medulla oblongataplus pons,striatum,midbrain,hypothalamus,hippoeampus and cortex).Forty-eight hours after CCI_(/4),injection therewere large increases of 5-HIAA in all six re-gions and increases of 5-HT in the medullaobiongata plus pons and hypothalamus.The NAconcentrations were reduced in the midbrain andhippocampus along with a decrease of DA in themidbrain.However,after EA treatment the incrementof 5-HIAA in the medulla oblongata plus ponsand hippocampus was reduced,but DA in themidbrain was increased significantly.The re-sults suggest that electroacupuncture definitelyassists normalization of the pathological increaseof 5-HT metabolism and decrease of DAcontent in rat brain caused by CCl_(/4),injection.A brief discussion is presented on the possi-ble mechanisms of acupuncture therapy in he-patic encephalopathy and other hepatic diseases. 相似文献
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<正> 一前言高血压病是最常见的心血管疾病,又是脑卒中、冠状动脉和外周动脉硬化的主要危险因素。根据其临床特点,可知本病多属中医的“头痛”、“眩晕”、“肝风”、“中风”等病证。中医认为其基本病机是阴虚阳亢,而且阴虚阳亢又是本病最常见的证型。本实验运用 相似文献