An Automated System for Leukofiltration of Blood Components

Biomedical Engineering - An automated system for filtering blood transfusion media through special filters, monitoring and logging the filtration parameters, and processing filtration protocols is...     

Studying the effect of the new beta-adrenoreceptor blocker proxodolol on the ischemic model of cardiac insufficiency

The effects of proxodolol--new beta-blocker with alpha-blocking activity--on system hemodynamics, heart function and morphology of rats with ischemia-induced congestive heart failure were studied and compared with those of carvedilol. It was shown that both drugs administered during 3 weeks after ligation of coronary artery inhibit heart remodeling and development of myocardial hypertrophy. Proxodolol was more effective than carvedilol in prevention of heart dysfunctions typical for congestive heart failure, that was especially evident during the pharmacological overload tests.     

Prediction of Safety Indicators for Donor Blood and Its Components in a Statistically Managed Technological Process Based on Bayesian Inversion

Biomedical Engineering - An algorithm predicting safety indicators for donor blood and its components in statistically controlled technological process based on Bayesian inversion was developed. A...     

An Automated Device for Defrosting of Erythrocyte Mass of Blood

Biomedical Engineering - An automated device for thawing packed red blood cells has been developed. The developed device provides highly accurate maintenance of heat transfer medium temperature and...     

An Automated Device for Defrosting of Blood Plasma

Biomedical Engineering - The results of development of an automated device for thawing blood plasma are presented. The developed device provides highly accurate maintenance of heat transfer medium...     

Effects of carvedilol and proxodolol on nitric oxide (NO) metabolism in various organs in a congestive heart failure model

There is certain evidence that high efficacy of beta-adrenoblockers with alpha-adrenoblocking effect (vasodilating beta-blockers) in congestive heart failure (CHF) can be explained by their effect on nitric oxide (NO) metabolism. In this context, the possible effects of carvedilol and proxodolol on the NO level in different organs have been studied on CHF model. The heart failure was modeled in rats by ligation of the coronary artery. Operated animals were divided into experimental groups treated with carvedilol or proxodolol and the untreated (control) group. In addition, a group of sham-operated animals was formed. After 28 days of treatment, the NO level was measured in heart, liver, and kidneys using the EPR method with spin trap. It was found that, in carvedilol-treated group, the NO level in liver is significantly lower than in other groups, which can be explained by the inhibitory action of carvedilol on the NO metabolism in this organ. The NO levels in myocardium and kidney in the control group were higher than in the sham-operated group, which confirms previous findings that the NO levels increases in CHF. Both drugs significantly decreased the NO concentration in myocardium and kidney tissue compared to control animals.