EFFECT OF GENGNIANKANG ON THE REPRODUCTIVE ENDOCRINE FUNCTION OF MALE RATS

Gengniankang did not increase the weight orreactivity of the testes to pituitary LH in old rats.No androgen activity was observed.The hCG/LHreceptor function of testis and the responsivity ofthe pituitary to LRH were enhanced by Gengnian-kang in old rats.By adjusting the function of thehormonal receptors the regulatory function of thehypothalamus-pituitary-gonads axis was improved,suggesting a possible endocrine mechanism of Geng-niankang in curing hypogonadism end climactericsyndrome of male and female.     

补肾补脾中药对大鼠甲状腺、肾上腺切除后卵巢功能减退的补偿治疗作用

大鼠肾上腺、甲状腺切除后,卵巢重量减轻,卵巢内 HCG/LH 受体功能降低。补肾中药(附子加熟地)能使上述动物卵巢增重,HCG/LH 受体功能提高。补脾中药(四君子汤)或者单用附子或熟地则无此作用。可能是补肾中药提高了卵巢对垂体促性腺激素的反应能力,从而使卵巢功能恢复。     

THE EFFECTS OF KIDNEY INVIGORATING CHINESE TRADITIONAL DRUGS ON THE FUNCTIONS OF THE HYPOTHALAMUS-PITUITARY-GONADS AXIS

Traditional Chinese Medicine regards thekidney as the foundation of innateness,with suchfemale reproductive functions as the menstrualcycle,ovulation,conception and delivery closelyrelated to that organ.Based on the principle ofoverall analysis of symptoms and signs,ChineseMedicine in the field of gynecology emphasizesthe importance of exuberance or insufficiency ofkidney vital energy.The Chinese traditionaldrugs(CTD)for invigorating the kidney play asignificant role in the treatment of variousobstetrical and gynecological diseases.In the     

更年康对雄性大白鼠生殖内分泌功能的影响

更年康不能提高老年大白鼠睾丸重量和睾丸对垂体LH反应性·也无雄激素作用,但它能提高老年大白鼠睾丸hCh/LH受体功能和垂体对LRH反应性,通过激素一受体功能调节,使老年大白鼠下脑丘—垂体—性腺轴功能得以改善,这可能是更年康治疗性机能减退和男女更年期综合征的内分泌作用机理。     

补肾药对下丘脑—垂体—性腺轴功能影响

祖国医学认为,肾为先天之本,肾主生殖,女性生殖机能如经、带、胎、产等都与肾有密切关系。故中医临床辨证在妇科方面十分重视肾气的盛衰。补肾中药对治疗多种妇产科疾病有重要作用。在妇科中西医结合研究中,也十分强调补肾的作用。为了阐明补肾中药作用机制,为临床应用和提高疗效提供理论基础和参考,本文研究了中医常用补肾中药菟丝子、巴戟天、熟地、肉苁蓉、仙茅、淫羊藿和枸杞子对下丘脑—垂体—性腺轴功能的影响,现将结果报道如下:     

补脾中药对强的松反馈抑制作用的影响

祖国医学认为;肾为先天之本,脾为后天之本,先天依赖后天水谷精微不断滋养。有谓肾非后天之气不能生,是补后天之脾,正以补先天之肾也。笔者用强的松灌动物,人为地造成垂体——肾上腺皮质系统功能低下(肾阳虚),以肾上腺组织中抗坏血酸含量为指标,用四君子汤加以调整,观察补脾中药对强的松反馈抑制作用的影响。材料与方法:实验动物与分组:正常雄性大白鼠60隻,体重150—250g;随机分生理盐水对照组、激素组(强的松)、激素 补脾中药组。药物制备及用量:党参、白术、茯苓、甘草等量共100g,第一煎加水700ml,浸泡半小时后文火煎沸30分钟,纱布过滤,收集滤液。第二煎加水300ml,煎煮如前,合并     

肺组织内两种β肾上腺素能受体的直接证明

本文作者应用~3 H标记的二羟基外搏停(~3H-DHA,一种β受体阻滞剂),与大鼠肺组织膜进行结合,直接证明了肺内存在β_1和β_2两型肾上腺素能受体,其比例为1:3。~3H-DHA与肺组织膜的结合具有高度亲和力和立体结构特异性,其药理学性质表明是结合在β受体上。此种特异性结合可代表总结合力的90％。在此基础上,作者应用了某些β受体阻滞剂来置换~3H-DHA的结合,其中有些是属于非选择性β阻滞剂,即对β_1和β_2受体都有同样的亲和力,有的则是β_1受体选择性阻滞剂。结果表明,非选择性β阻滞剂如噻吗心安