甲状腺功能亢进症中医证候分布规律的研究

Objective To Analyze the distribution characteristics of Hyperthyroidism's syndrome and the relationship between symptoms and thyroid hormones. Methods The TCM syndromes of a total of 78 patients with hyperthyroidism were differentiated. The relationship between syndrome and general condition of patients (gender and age, etc.) were analyzed;correlation between symptoms and thyroid hormones were also studied. Results Of all 78 patients, patients with yin deficiency and hyperactive yang accounted for 43.6%; patients with internal disturbance of phlegm-fire accounted for 30.8 %; and patients with hypteracitivity of heart-fire and liver-fire accounted for 25.6%. The severity of all the symptoms showed positive correlation with hyroid hormones (the value of r is positive, P＜0.05); and no linear relationship with TSH (P＞0.05).Conclusion The syndrome of yin deficiency and hyperactive yangI was the most common syndrome type. Thyroid hormones had direct proportion with the severity of syndrome.     

2型糖尿病肾病血瘀证与临床指标的相关性

目的:探讨糖尿病肾病血瘀证与尿蛋白定量等临床指标的相关性。方法:选取60例糖尿病肾病(Ⅳ期)患者,经过中医辨证,分为血瘀证组和非血瘀证组,对患者的一般资料,生化指标及四诊信息进行统计分析,比较两组之间的差异,并进行相关性分析。结果:两组糖尿病肾病血瘀证患者血红细胞计数、血红蛋白含量和24小时尿蛋白定量比较有统计学意义(P0.05),血瘀证组的血红细胞计数、血红蛋白含量和24小时尿蛋白定量均大于非血瘀证组。两组进行Spearman相关分析,血红细胞计数、血红蛋白含量以及24小时尿蛋白定量与血瘀证有正相关关系。结论:通过对糖尿病肾病血瘀证的研究,提示血瘀证与血红细胞及尿蛋白有一定的相关性。     

甲状腺功能亢进症中医证候分布规律的研究

目的 探讨甲亢的中医证候分布规律及各证候所表现的症状与激素的相关性.方法 对78例甲亢患者的中医证候进行判断,分析证候与患者一般情况(性别、年龄等)的相关性及证候中的症状与激素的相关性.结果 78例甲亢患者中阴虚阳亢占43.6%;痰火内扰占30.8%:心肝火旺占25.6%.各证候中症状的轻重与甲状腺激素均呈正相关关系(r为正值,P＜0.05),与甲状腺激素水平无直线关系(P＞0.05).结论 甲亢的中医证候以阴虚阳亢最常见;在痰火内扰、心肝火旺、阴虚阳亢三型中,甲状腺激素水平越高,则各证型对应的症状可能越重.     

痰湿与2型糖尿病脂代谢紊乱的相关性临床研究

[目的] 探讨痰湿与2型糖尿病(type 2 diabetes mellitus,T2DM)脂代谢紊乱的相关性。[方法] 收集833例T2DM患者的临床资料,分析比较痰湿证与非痰湿证患者的肾功能指标与总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low density lipoprotein-cholesterol,LDL-C)、高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)水平,并探究T2DM患者血脂水平与肾功能指标及痰湿程度的相关性。[结果] 与非痰湿证患者比较,痰湿证患者尿素氮、血肌酐、尿酸水平均升高(P＜0.01),估算肾小球滤过率(estimated glomerular filtration rate,eGFR)降低(P＜0.01);TC、TG、LDL-C水平升高(P＜0.01),HDL-C水平降低(P＜0.05)。TC与尿素氮呈正相关,与eGFR呈负相关;TG与血肌酐、尿酸呈正相关,与eGFR呈负相关;LDL-C与尿素氮、血肌酐呈正相关,与eGFR呈负相关;HDL-C与血肌酐、尿酸呈负相关;痰湿证与TC、LDL-C呈正相关,随痰湿程度加重,其相关系数增加,轻度痰湿证与HDL-C呈负相关。[结论] T2DM痰湿证患者脂代谢紊乱程度更严重,肾功能更差。痰湿证是血脂水平发生异常的危险因素之一,脂代谢紊乱与T2DM早期肾功能损伤密切相关。本研究为从痰湿纠正T2DM脂代谢异常、延缓肾脏损伤提供了新思路。