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男科学组织工程研究前景 总被引:4,自引:3,他引:1
利用组织工程技术进行细胞移植的设想 ,已经为男科领域的组织再建工作提供了许多可能。为改善、修复或替代现有组织的功能 ,组织工程的应用研究 ,已经在睾丸间质细胞、睾丸假体、阴茎海绵体、阴茎假体等方面开展。虽然大多数再建工作仍然停留在实验阶段 ,但是有些技术也被用于临床 ,并取得满意的结果。本文简要地综述了组织工程在男科学的应用 相似文献
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J. Alidjanov J. Wolf H.‐C. Schuppe W. Weidner T. Diemer T. Linn I. Halefeldt F. Wagenlehner J. Wiltink A. Pilatz 《Andrologia》2014,46(10):1189-1197
As commonly used self‐reported screening instruments for male hypogonadism demonstrated lack of specificity, a Hypogonadism Related Symptom Scale (HRS) was developed in 2009 as a novel self‐rating screening tool. As the questionnaire has not been validated, the purpose of our study was to perform a validation in patients presenting with different disorders (e.g. infertility, HIV infection or metabolic syndrome) and disease‐related risk to develop hypogonadism. Two hundred and eighteen patients aged 19–71 years (40.1 ± 9.5) who completed the HRS and other common questionnaires [International Index Of Erectile Function (IIEF), National Institutes of Health Chronic Prostatitis Symptom Index (NIH‐CPSI), Hospital Anxiety and Depression Scale (HADS), short form (SF)‐12] were included. In all patients, blood levels of total testosterone, luteinizing hormone, follicle‐stimulating hormone, oestradiol and sex hormone‐binding globulin were determined and free testosterone was calculated. Cronbach's α for the scale was 0.896, split‐half 0.871 for the 1st half and 0.807 for the 2nd half. Spearman–Brown coefficient was 0.767, and Guttman split‐half coefficient was 0.759. Consistent correlations were found between HRS and IIEF5 (ρ = 0.57, P < 0.001), and HADS (ρ = ?0.6, P < 0.001). In addition, HRS was significantly correlated with total testosterone (ρ = 0.135, P < 0.05), free testosterone (ρ = 0.148, P < 0.05) and oestradiol (ρ = ?0.134, P < 0.05). Our validation study confirms the data from the initial development of the HRS questionnaire. Clinicians might have an additional advantage from the HRS when investigating males with suspected hypogonadism. 相似文献
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Qi-Gang Zheng Zhao-Hui Sun Jia-Jian Chen Jia-Cheng Li Xiao-Jun Huang 《World Journal of Clinical Cases》2021,9(2):457-462
BACKGROUNDParatesticular liposarcoma accounts for approximately 7% of scrotal tumors. They are rare lesions of the reproductive system with approximately 90% of the lesions originating from the spermatic cord. Surgery, with the goal of complete resection, is the mainstay for treatment of this disease. However, treatment consisting of extended resection to decrease local recurrence remains controversial.CASE SUMMARYWe report the cases of two patients with paratesticular liposarcomas who were treated with radical testicular tumor resection without adjuvant therapy. Follow-up investigations at 9 mo showed no sign of recurrence.CONCLUSIONSurgery is the first-line treatment, regardless of whether it is a recurrent or primary tumor. Extended resection carries a higher risk of complications and should not be performed routinely. Preoperative radiotherapy can reduce the local recurrence rate without affecting the overall survival. 相似文献
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M. Yanishi H. Kinoshita H. Tsukaguchi Y. Kimura Y. Koito M. Sugi T. Matsuda 《Transplantation proceedings》2018,50(10):3371-3375
Introduction
Sarcopenia and osteopenia are highly prevalent in older patients, and are associated with a high risk for falls, fractures, and further functional decline. However, related factors in kidney transplant recipients suffering from osteosarcopenia, the combination of sarcopenia and osteopenia, remain unknown.Material and methods
Fifty-eight transplant recipients (42 men and 16 women), with a mean age of 46.6 ± 12.7 years, were enrolled in this study. Sarcopenia was diagnosed according to the criteria of the Asia Working Group for Sarcopenia. Osteopenia was diagnosed according to World Health Organization criteria using bone mineral density (BMD) of the lumbar spine. Patients who met the diagnostic criteria of both diseases were defined as having osteosarcopenia.Results
Ten patients had osteosarcopenia. According to univariate analyses, there were significant differences between osteosarcopenia group and non osteosarcopenia group in age (P = .002), duration of dialysis (P = .013), vitamin D levels (P = .002), and MET (P = .007). There was a significant positive correlation between vitamin D level and MET (r = .464; P < .001). The results of the multivariate analysis indicated that only MET was a relevant factor in osteosarcopenia.Conclusion
Duration of dialysis, low vitamin D levels, and physical activity after kidney transplantation were related to osteosarcopenia. These results suggested that osteosarcopenia in kidney transplant recipients is a carryover from the dialysis period. 相似文献8.
B. A. Keel 《Systems biology in reproductive medicine》2013,59(6):417-431
The primary goal of any andrology laboratory should be the performance of accurate, reproducible, high-quality, and clinically relevant laboratory testing. An underlining objective of such a goal is to better serve the ordering physician, and the patient, by continually improving laboratory performance. Quality control (QC) is the procedure that determines accurate and reproducible testing. Proficiency testing (PT) is the process allowing physicians to compare results from one laboratory to another. Quality assurance (QA) is the mechanism ensuring high-quality, clinically relevant testing. Together, QC, QA, and PT serve as the foundation responsible for a program that continually improves the overall quality of the testing, allowing the physician ordering the test to be more effective in treating the patient. Several examples are presented to assist the implementation of effective QC and QA programs aimed at continually improving performance in the andrology laboratory. 相似文献
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