1例机械通气下鹦鹉热衣原体重症肺炎患者的护理

总结1例机械通气下鹦鹉热衣原体重症肺炎患者的护理。护理主要内容如下:个人防护及探视管理、病情观察、机械通气护理要点、负压病房消毒监测、排痰管理、营养支持、静脉血栓栓塞症预防、健康宣教。经过积极治疗和精心护理,23天后患者好转出院。     

外周血免疫细胞在NAFLD疾病进展中的诊断价值

近日,范建高教授应《柳叶刀》旗下子刊EBioMedicine(影响因子8.413分)编辑部邀请,与博士生林双喆在线发表综述:Peripheral immune cells in NAFLD patients:A spyhole to disease progression,EBioMedicine 2021 doi.org/10.1016/j.ebiom.2021.103768,系统分析非酒精性脂肪性肝病(NAFLD)及其不同临床病理类型亚组患者循环外周血液各种免疫细胞的特征性变化,并探讨了外周血免疫细胞变化用于无创诊断与评估NAFLD的严重类型非酒精性脂肪性肝炎(NASH)的潜在价值。     

新生儿呼吸窘迫综合征机械通气治疗中联合体位干预对血气指标及并发症的影响

目的评价分析机械通气治疗中联合体位干预对新生儿呼吸窘迫综合征患儿血气指标以及并发症的影响。方法纳入62例肇庆市广宁县人民医院在2019年6月-2020年12月收治的新生儿呼吸窘迫综合征患儿进行研究,以随机数表法作为分组工具,分成对照组(n=31例,仰卧位机械通气治疗)、观察组(n=31例,体位干预联合机械通气治疗),比较两组新生儿治疗干预前后血气指标变化[氢离子浓度指数(pH值)、氧合指数(OI)、动脉血氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))]以及治疗后并发症(腹胀、败血症、肺出血、颅内出血)发生率。结果观察组治疗干预后pH值、OI、PaO_(2)三项指标水平高于对照组(P<0.05),PaCO_(2)指标水平低于对照组(P<0.05);观察组并发症发生率低于对照组(P<0.05)。结论在新生儿呼吸窘迫综合征患儿接受机械通气治疗时采取体位干预,变化侧卧、仰卧、俯卧等不同体位具有显著的积极影响,可更好的改善患儿血气指标,实现良好氧合状态,抑制并发症,更适用于现代临床,值得推广。     

经鼻高流量氧气湿化治疗老年慢性阻塞性肺疾病急性加重合并呼吸衰竭的可行性研究

ObjectiveTo investigate the feasibility of transnasal heated humidified high flow nasal cannula oxygen therapy (HFNC) in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with respiratory failure in elderly patients. MethodsA total of 176 elderly patients with AECOPD complicated with respiratory failure who were hospitalized at Peking University Shougang Hospital from December 2016 to January 2022 were enrolled, including 82 patients in an HFNC group and 94 patients in an NPPV group. After treatment, pulse oxygen saturation (SPO₂), arterial partial pressure of carbon dioxide (PaCO₂), oxygenation index (OI), respiratory rate (RR), heart rate (HR), mean arterial pressure (MAP), comfort score, discharge rate, rate of endotracheal intubation, rate of transfer to intensive care unit (ICU), and mortality were compared between the two groups. The independent sample t-test was used for comparison between the two groups. Statistical data are expressed in percentage or number of cases and the χ² test was used for their comparisons. ResultsThe SPO₂ values at 30 min, 1 h, and 6 h were significantly higher in the HFNC group than in the NPPV group (t=-2.049,-2.618, and -3.314, P=0.043, 0.010, and 0.001, respectively). SPO₂ before discharge was significantly lower than that of the NPPV group (t=2.162, P=0.033), but OI at each time point and before discharge had no statistical significance (P＞0.05). MAP at 6 h was significantly higher in the HFNC group than in the NPPV group (t=-2.209, P=0.029), but within the normal range. HRs at 2 h and 3 h in the HFNC group were significantly higher than those of the NPPV group (t=-2.199 and -2.336, P=0.030 and 0.021, respectively). There were no significant differences in RR, HR, or MAP between the two groups at other time points and before discharge (P＞0.05). There was no significant difference in PaCO2 between the two groups (P＞0.05). Comfort score in the HFNC group was significantly higher than that of the NPPV group (t=-46.807, P＜0.001). There were no significant differences in discharge rate, ICU transfer rate, endotracheal intubation rate, and mortality between the two groups (P＞0.05). ConclusionHFNC is as effective as NPPV in treating elderly patients with AECOPD complicated with type Ⅰ or mild type Ⅱ respiratory failure, and HFNC is more comfortable than NPPV.