Synthesis of novel polycarbonyl Schiff bases by ring-opening reaction of ethyl 5-acyl-4-pyrone-2-carboxylates with primary mono- and diamines

An approach for the introduction of the tricarbonyl moiety into aromatic, heterocyclic, and aliphatic amines with the use of acylpyrones has been developed for the synthesis and the design of novel polycarbonyl Schiff base ligands, including salphen structures. This Michael addition–ring-opening reaction proceeds under mild conditions (stirring at 0–20 °C) via the attack at the C-6 position of the pyrone ring in good to high yields (up to 99%) with excellent selectivity. The products can be easily isolated by crystallization without the use of chromatography. The scope of the reaction, tautomeric equilibrium of open-chain products, and their cyclization into pyridone structures were investigated.

An approach for the introduction of the tricarbonyl moiety into various amines has been developed based on acylpyrones.     

血浆纤维蛋白原D-二聚体术后检测应用探讨

目的探讨术后长期卧床患者进行D-二聚体（D-D）和纤维蛋白原（Fg）检测的临床意义。方法分别用透射比浊法和酶联免疫吸附试验法（ELISA）测定术后需长期卧床患者的Fg和D-D，比较二者与健康对照组、一般组及术前后的差异。结果一般组和卧床组术后第2天和第5天与健康对照组及术前的D-D和Fg比较均升高，差异均有统计学意义（P〈o．05）。卧床组在术后5dD-D和Fg均较一般组高，而且与卧床组第2天相比检测水平也升高，差异具有统计学意义（P〈0．05）。结论术后卧床患者及时检测Fg、D-D能有效监测静脉血栓的形成，使临床医生能及时采取有效的预防措施，避免并发症的发生。     

Epidemic and evolutionary characteristics of peste des petits ruminants virus infecting Procapra przewalskii in Western China

Due to the migration or transboundary spread of domestic and wild animals, peste des petits ruminants virus posed a high potential threat to them. In this study, we initially detected that a class of animal named Procapra przewalskii was infected with peste des petits ruminants virus (PPRV ChinaGS2018) in Gansu province. According to phylogenetic relationships analysis, we found that ChinaGS2018 comprised of 15,954 nucleotides and was classified into IV genotypes. In addition, indirect immunofluorescence assay (IFA) showed that ChinaGS2018 could infect isolated primary goat tracheal epithelium cells (GTC). Comparing with full-length genome sequences revealed that ChinaGS2018 strain has high identity to the reference complete genomes (87.16–99.55%) at the nucleotide level. Multiple sequence alignment showed that F protein has the highest identity of 99.8%, and H protein has the highest nucleotide substitution ratio. Our study also suggested this strain may be transmitted from Xinjiang, China. Along with the migratory of Procapra przewalskii, this wild ruminant infected with PPRV can pose a huge threat to other wild ruminants and domestic ones. This is the first report describing infected with PPRV which will provide insights into the epidemiology and pathogenesis of this important virus.     

86例急性脑梗塞患者糖化血红蛋白检测结果分析

目的：探讨糖化血红蛋白检测在急性脑梗塞中的临床价值。方法：回顾性分析2007年01月-2009年10月我院收治的86例急性脑梗塞患者糖化血红蛋白检测结果,其中急性脑梗塞无糖尿病患者47例,急性脑梗塞伴糖尿病患者39例,并将两组结果作对比分析。结果：急性脑梗塞伴糖尿病患者组糖化血红蛋白明显高于急性脑梗塞无糖尿病患者组,两组比较有显著性差异（P〈0．05）。结论：糖化血红蛋白检测是鉴别糖尿病性与非糖尿病性脑梗塞的一个敏感指标。     

孕妇哮喘防治中的误区与对策

目的观察妊娠期哮喘治疗效果及安全性。方法将我院(2009年1月1日至2012年1月1日)明确诊断的64例孕妇哮喘急性发作期患者,予以抗炎、解痉、平喘、祛痰等治疗后,观察治疗前、后的临床症状评分、肺功能指标(FEV1、FEV1占预计值的%)及药物不良反应。结果孕妇哮喘症状得到控制,胎儿未发生宫内缺氧。结论治疗哮喘的大多数药物对胎儿是比较安全的,而未控制的哮喘的风险远远高于哮喘治疗药物对妊娠造成的风险。     

Biohydrogels with magnetic nanoparticles as crosslinker: Characteristics and potential use for controlled antitumor drug-delivery

Hybrid magnetic hydrogels are of interest for applications in biomedical science as controlled drug-delivery systems. We have developed a strategy to obtain novel hybrid hydrogels with magnetic nanoparticles (NPs) of CoFe₂O₃ and Fe₃O₄ as crosslinker agents of carboxymethylcellulose (CMC) or hyaluronic acid (HYAL) polymers and we have tested these systems for controlled doxorubicin release. The magnetic NPs are functionalized with (3-aminopropyl)trimethoxysilane (APTMS) in order to introduce amino groups on the surface. The amino coating is determined and quantified by standard Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy methods, and by cyclic voltammetry, a novel approach that permits us to look at the solution properties of the functionalized NPs. The gel formation involves the creation of an amide bond between the carboxylic groups of CMC or HYAL and the amine groups of functionalized NPs, which work as crosslinking agents of the polymer chains. The hybrid hydrogels are chemically and morphologically characterized. The rheological and the water uptake properties of the hydrogels are also investigated. Under the application of an alternating magnetic field, the CMC–HYAL hybrid hydrogel previously loaded with doxorubicin shows a drug release greater than that showed by the CMC–HYAL hydrogel crosslinked with 1,3-diaminopropane. In conclusion, the presence of magnetic NPs makes the synthesized hybrid hydrogels suitable for application as a drug-delivery system by means of alternating magnetic fields.     

妊娠期糖尿病合并妊娠肝内胆汁淤积症对围产儿的影响

目的探讨妊娠期糖尿病合并妊娠肝内胆汁淤积症对围产儿结局的影响。方法回顾性分析我院2008年1月～2010年10月住院分娩的妊娠期糖尿病合并妊娠期肝内胆汁淤积症（GDM＋ICP组）孕妇180例临床资料,与同期住院的妊娠期糖尿病（GDM组）426例、妊娠期肝内胆汁淤积症（ICP组）474例孕妇所分娩围产儿的结局情况分别进行比较。结果 GDM＋ICP组34周前终止妊娠率、新生儿窒息率、Ⅱ度以上羊水粪染率、小于胎龄儿发生率显著高于其余两组（P〈0.05）。结论妊娠期糖尿病合并妊娠肝内胆汁淤积症围产儿不良结局风险增加,应加强胎儿监护,适时终止妊娠,提高出生质量。     

二甲双胍抗膀胱癌药理机制的研究进展

二甲双胍已成为临床治疗2型糖尿病的一线口服降糖药,最新研究表明二甲双胍除了能通过改善胰岛素抵抗、抑制肝脏糖异生等参与调节血糖水平外,还能明显降低糖尿病患者中卵巢癌、肝癌、肺癌等多种癌症的发生率、复发率和死亡率。综述了二甲双胍能通过激活AMPK信号通路、诱导细胞周期停滞及细胞凋亡、抑制血管生成、抑制膀胱癌干细胞增殖、增强化疗药物等对膀胱癌细胞的疗效等多种分子机制产生抗膀胱癌的作用,展望了其成为新一代治疗膀胱癌药物的可能。     

Dietary Inflammatory Index and Leukoaraiosis in Patients with Ischemic Stroke

The journal of nutrition, health & aging - Diet may change the chronic levels of systemic inflammation, which in turn influence the development of leukoaraiosis (LA). This study aimed to...