Growing self-organizing trees for autonomous hierarchical clustering

This paper presents a new unsupervised learning method based on growing processes and autonomous self-assembly rules. This method, called Growing Self-organizing Trees (GSoT), can grow both network size and tree topology to represent the topological and hierarchical dataset organization, allowing a rapid and interactive visualization. Tree construction rules draw inspiration from elusive properties of biological organization to build hierarchical structures. Experiments conducted on real datasets demonstrate good GSoT performance and provide visual results that are generated during the training process.     

黄风湿系列疗法—火针封闭治疗痛风石的疗效观察

痛风是一种由嘌呤代谢紊乱所致的疾病,日久不愈反复发作则逐渐形成痛风石沉积。常规治疗对痛风石效果不明显。采用火针封闭疗法治疗痛风石36例,经临床观察治愈率为69．4％,显效率为25．0％,有效率为5．6％,总有效率达100％。     

《金匮要略》历节病“过食酸咸,筋缓骨痿”辨析

释疑《金匮要略》历节病"过食酸咸,筋缓骨痿"条文,指出"泄"为湿盛,"枯"为精血不足,"枯泄相搏"为瘀血寒湿胶结,血行不畅,"四属"为四肢。张仲景强调历节病在四肢关节,病理机制为虚实夹杂,内有肝肾不足、气血虚弱,外有关节瘀血寒湿胶结,易于化热。该条文充分体现了仲景重视"五脏元真通畅,人即安和"的思想。     

新HH方对HBV转基因小鼠脾脏源DC相关的免疫耐受状态影响的研究

目的:探讨新HH方对乙型肝炎病毒(Hepatitis B Virus,HBV)转基因小鼠脾脏源树突状细胞(Dendritic cell,DC)相关的"免疫耐受"状态影响。方法:取新HH方治疗过和未治疗过的转基因小鼠脾脏来源的单个核细胞,以重组小鼠粒细胞-巨噬细胞集落刺激因子(recombinant Mouse Granulocyte Macrophage-Colony Stimulatory Factor,rmGMCSF)和重组小鼠白细胞介素-4(Recombinant Mouse IL-4,rmIL-4)培养诱导DC,流式细胞仪检测其表面共刺激分子(CD80、CD86),MTT法检测其刺激同种异体淋巴细胞增殖的能力,酶联免疫法(ELISA)法测定培养上清液中白介素-12(Interleukin-12,IL-12)、白介素-10(Interleukin-10,IL-10)水平。结果:新HH方组小鼠DC的表面协同刺激分子(CD 86)表达水平(13.7±3.1)、刺激同种异体淋巴细胞增殖能力(1:50和1:10 SI分别为1.22±0.09、1.69±0.10)和细胞因子IL-12水平(256.72±29.75)均高于对照组(154.69±11.32)(P<0.05),细胞因子IL-10水平(45.32±11.28)均低于对照组(76.79±16.26)(P<0.05)。结论:新HH方可以促进HBV转基因小鼠DC的成熟,上调其表面协同刺激分子CD86的表达,增强了其促淋巴细胞细胞增殖和分泌IL-12的能力,加强其抗原递呈能力,抑制分泌IL-10,从而打破DC相关的免疫耐受状态。     

Association between Ambient Air Pollution and Hospital Emergency Admissions for Respiratory and Cardiovascular Diseases in Beijing:a Time Series Study

Objective To investigate the association between ambient air pollution and hospital emergency admissions in Beijing.
Methods In this study, a semi-parametric generalized additive model (GAM) was used to evaluate the specific influences of air pollutants (PM10, SO2, and NO2) on hospital emergency admissions with different lag structures from 2009 to 2011, the sex and age specific influences of air pollution and the modifying effect of seasons on air pollution to analyze the possible interaction.
Results It was found that a 10 μg/m3 increase in concentration of PM10 at lag 03 day, SO2 and NO2 at lag 0 day were associated with an increase of 0.88%, 0.76%, and 1.82% respectively in overall emergency admissions. A 10 μg/m3 increase in concentration of PM10, SO2 and NO2 at lag 5 day were associated with an increase of 1.39%, 1.56%, and 1.18% respectively in cardiovascular disease emergency admissions. For lag 02, a 10 μg/m3 increase in concentration of PM10, SO2 and NO2 were associated with 1.72%, 1.34%, and 2.57% increases respectively in respiratory disease emergency admissions.
Conclusion This study further confirmed that short-term exposure to ambient air pollution was associated with increased risk of hospital emergency admissions in Beijing.     

中草药上下进入阴阳平衡疗法治疗全身型重症肌无力69例临床观察

目的：为重症肌无力患者寻找一种减轻痛苦、疗效显著的治疗方法。方法：取2组患者分别采用“黄风湿”系列疗法和中草药上下进入阴阳平衡疗法，对患者的治疗效果进行观察。结果：采用中草药上下进入阴阳平衡疗法治疗的患者疗程短、复发率低，与对照组比较差异有统计学意义（P〈0．01）。结论：采用中草药上下进入阴阳平衡疗法治疗全身型重症肌无力疗效确切，是一种安全、可靠、值得推荐的治疗方法。