慢性前列腺炎／慢性骨盆疼痛综合征心理疗法述评

慢性前列腺炎／慢性骨盆疼痛综合征（CP／CPPS）是成年男性泌尿生殖系统常见病和多发病，其病因复杂，临床疗效欠佳。疼痛不适作为其最主要的症状之一，是诸多患者前往医院就诊的主要原因，也是影响患者生活质量的重要因素。大量研究表明精神心理因素与其疼痛症状的发生、发展及预后关系甚密。因此，临床上心理疗法的应用非常重要。     

基于“肝藏”理论的疏肝养血法对肝郁血虚ED大鼠血液流变学的影响

目的:基于"肝藏"理论,从血液流变学角度研究疏肝养血法对肝郁血虚ED大鼠的干预作用。方法:选取经交配后证实有正常勃起功能的雄性SD大鼠30只,随机分为空白组、模型组、疏肝养血组,每组10只,采用尾部放血和悬吊激惹方法配合低铁饮食制备肝郁血虚勃起功能障碍模型,给以四物汤与逍遥散合方煎剂灌胃14d,取股动脉血液,检测血液流变学指标。结果:与空白组相比,模型组全血黏度切变率、全血还原黏度、血浆黏度、红细胞压积、红细胞聚集指数、红细胞变形指数TK明显升高(P0.01);与模型组相比,疏肝养血组全血黏度切变率、全血还原黏度、血浆黏度、红细胞压积、红细胞聚集指数、红细胞变形指数TK有所降低(P0.05)。结论:改善血液流变学指标可能是基于"肝藏"理论,疏肝养血法治疗ED的物质基础及作用机制。     

翁沥通胶囊联合α受体阻滞剂治疗CP/CPPS临床有效性评价

目的 评价翁沥通胶囊联合α受体阻滞剂治疗慢性前列腺炎/慢性盆腔疼痛综合征(CP/CPPS)的临床有效性.方法 采用随机、对照的临床试验方法,将180例CP/CPPS患者随机分为三组(中药组/西药组/联合组),各60例,分别采用翁沥通胶囊、α受体阻滞剂多沙唑嗪控释片、翁沥通胶囊+多沙唑嗪控释片治疗,疗程4周,分析NIH-CPSI评分(疼痛症状评分)并评价其有效性.结果 各组患者治疗4周后,NIH-CPSI疼痛症状评分均有一定程度降低(P＜0.01,或P＜0.05).结论 翁沥通胶囊联合α受体阻滞剂多沙唑嗪控释片联合用药对CP/CPPS患者疼痛症状疗效较为显著.     

左侧输精管完全缺如合并右侧输精管部分缺如1例报道

据报道,近半个世纪以来,全球不育症的发病率已从8％-10％上升到了12％～16％。目前全球至少有8000万对不育夫妇,并正以每年200万对的速度在递增,在这些不育病例中,50％是由男性不育引起的。其中因无精子症导致男性不育者约占10％～20％,先天性输精管缺如（congenital absence of the vas deferens,CAVD）是男性不育的重要原因之一,占无精子症的9．1％～26．7％E3]。临床上常见双侧或单侧完全缺如,部分缺如者少见,而一侧完全缺如,另一侧部分缺如者更少见。     

精索静脉曲张的中西医结合治疗进展

精索静脉曲张（Varicocle,VC）是指精索静脉内蔓状静脉丛的异常伸长、扩张和迂曲,是青壮年男性的常见疾病,发病率为10％～15％,以左侧发病为多。一般认为主要是由于精索静脉回流受阻或瓣膜失效,血液返流引起血液瘀滞,导致蔓状静脉迂曲扩张所致。因本病多影响睾丸生精功能,因此易造成精液异常而致不育。近年来随着中西医男科学的发展,人们对其进行了大量的、不同层面的研究,应用中医药治疗本病结合西医手术治疗也取得了长足的进步和发展。现就近年来中医及中西医结合治疗本病的进展状况作一综述。     

泌尿系统感染病原菌的耐药性分析及临床治疗

目的调查泌尿系统感染病原菌的分布及耐药性,为泌尿系感染的临床治疗提供依据。方法对2010年8月～2012年3月在我院诊断住院治疗的泌尿系感染患者的265份尿液进行常规鉴定和药物敏感性监测。结果泌尿系感染患者主要与大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌等革兰氏阴性菌和金黄色葡萄球菌等革兰氏阳性菌感染有关。结论泌尿系感染患者应根据尿培养和药敏试验的结果选用合适的药物进行治疗,避免抗生素滥用现象的发生。     

阳痿肾阳虚证同证异治浅析

阳痿多辨证为肾阳虚证,一般治疗以补肾为主,但不同疾病所致阳痿疗效不同,故阳痿当同证异治,根据不同疾病导致的阳痿,采用不同治法,不能局限于同证同治,方可获效.     

红景天多糖对精原干细胞体外增殖的影响

BACKGROUND: To establish a rapid and effective method to obtain sufficient spermatogonial stem cells that can meet the clinical need is urgent to be solved in the spermatogonial stem cell transplantation. OBJECTIVE: To study the effect of rhodiola polysaccharide on the proliferation of spermatogonial stem cells in vitro. METHODS: Under sterile conditions, spermatogonial stem cells and Sertoli cells were isolated from the testis of mice, and spermatogonial stem cells were seeded onto the feed layer of Sertoli cells. Then, the co-cultured cells were assigned into experimental group 1 (simple cell culture medium), experimental group 2 (cell culture medium containing 150 mg/L rhodiola polysaccharide) and experimental group 3 (cell culture medium containing 150 mg/L rhodiola polysaccharide, 1 U/L leukemia inhibitory factor and 10 μg/L glial cell line-derived neurotrophic factor). After 7 days of co-culture, flow cytometry was used to detect cell proliferation in vitro, and cell viability and positive expression of GFRa-1, Thy-1 and C-kit were calculated. RESULTS AND CONCLUSION: After 7 days of co-culture, the cells grew rapidly and presented with colony and thyrsiform growth, and the number of cell masses increased significantly, all of which were in line with the proliferative features of spermatogonial stem cells. The GFRa-1, Thy-1 and C-kit proteins were expressed in the cell membrane and cytoplasm, mainly in the cell membrane. The viability of spermatogonial stem cells and positive expression of GFRa-1 and Thy-1 were ranked as follows: experimental group 3 > experimental group 2 > experimental group 1, and there were significant differences between groups (P < 0.05). The positive expression of C-kit had no difference between experimental groups 1 and 2, but it was significantly higher in the experimental group 3 than the other two groups (P < 0.05). These findings indicate that rhodiola polysaccharide used alone or combined with leukemia inhibitory factor and glial cell line-derived neurotrophic factor can enhance the proliferative ability of spermatogonial stem cells in vitro.  中国组织工程研究杂志出版内容重点：干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程     

盐酸舍曲林联合坦索罗辛治疗早泄并发焦虑50例

目的 评价盐酸舍曲林片联合坦索罗辛缓释胶囊治疗早泄并发焦虑的临床疗效. 方法 将100例早泄并发焦虑患者随机分为两组,各50例,治疗组口服盐酸舍曲林片,每晚50 mg;坦索罗辛缓释胶囊,每晚0.2 mg. 对照组口服盐酸舍曲林片,用法用量同治疗组. 均4周为1个疗程. 记录并分析患者治疗前后平均阴道内射精潜伏时间、双方性交满意度及焦虑症状评分. 结果 治疗组、对照组患者平均阴道内射精潜伏时间、双方性交满意度及焦虑症状评分较治疗前差异有统计学意义(P<0.05或P<0.01). 治疗组治疗后平均阴道内射精潜伏时间延长,双方性交满意度提高,均较对照组差异有统计学意义(P<0.05或P<0.01). 结论 盐酸舍曲林片联合坦索罗辛缓释胶囊可明显延长早泄并焦虑患者平均阴道内射精潜伏时间,提高性交满意度,缓解焦虑,且优于单纯应用盐酸舍曲林片.