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1.
酵母样真菌感染的菌群临床分布与药敏分析 总被引:4,自引:0,他引:4
目的了解临床酵母样真菌的感染类型、分布及其对常用抗真菌药物的敏感性,为临床诊断治疗提供正确的用药依据。方法采用常规方法分离培养真菌,用法国生物梅里埃公司生产的ATB Expression微生物自动鉴定/药敏分析仪进行真菌鉴定和药敏分析。结果396株酵母样真菌中,白色假丝酵母菌检出率最高(72.3%),其次为热带假丝酵母菌(15.91%),光滑假丝酵母菌(6.82%)。酵母样真菌对5-氟胞嘧啶、两性菌素B、氟康唑、依曲康唑的敏感性分别为98.02%,98.43%,77.38%,77.76%。结论临床酵母样真菌感染以白色假丝酵母菌为主,对5-氟胞嘧啶、两性菌素B敏感性较高,对氟康唑、依曲康唑有不同程度的耐药,因此,药敏监测是非常必要的,临床医生应根据药敏结果合理使用抗真菌药物。 相似文献
2.
Total global biodiversity is estimated at between 3 and 500 × 106 species of prokaryote and eukaryote organisms spread across 70 or more phyla. The marine macrofauna alone are estimated between 0.5 and 30 × 106 species and represents a broader range of taxonomic diversity than that found in the terrestrial environment, which has been the traditional source of natural products. With a typical eukaryote possessing 50,000 genes, the global marine macrofauna are the source of 2.5 × 1010 to 1.5 × 1012 primary products and an associated extensive range of secondary products. However, only a few thousand novel compounds from marine organisms have been described. These compounds have proven unique in chemical and pharmacological terms but, as yet, no therapeutic agents have resulted. Given a broader drug discovery strategy, and facilitated by technological advances, it is predicted that the characterisation of marine chemical diversity will be accelerated. Strategies for drug discovery from the virtually untapped chemical diversity of marine organisms are discussed. © 1994 Wiley-Less, Inc. 相似文献
3.
Suppurative corneal ulceration in Bangladesh 总被引:8,自引:0,他引:8
AAS Dunlop MB BS ED Wright MRCPath † SA Howlader‡ I Nazrul‡ R Husain‡ K McClellan FRACO § FA Billson FRACO § 《Clinical & experimental ophthalmology》1994,22(2):105-110
Suppurative keratitis is an important preventable cause of blindness, particularly in the developing world. This study analyses 142 cases of suppurative keratitis referred to Chittagong Eye Infirmary, Bangladesh. Some 53.5% of cases were bacterial and 35.9% were fungal. The five most common pathogens were: Pseudomonas sp. 24%, Streptococcus pneumoniae 17%, Aspergillus sp. 13%, Fusarium sp. 7% and Curvularia sp. 6%. Gram stain and culture results were consistent in 62.6% of cases. Previous antibiotic treatment was a significant factor for failure of culture isolation and less so for Gram stain failure. On Gram stain, 55.9% of pseudomonal cases were missed, but only 2% of fungal cases were missed. Over all, Gram stain had a sensitivity of 62% and positive predictive value of 84% for bacterial cases, and 98% and 94% for fungal cases, respectively. Fungal ulcers were typically filamentous, but an antecedent history of trauma was not common. The most frequent injury was due to rice grains, but the inoculum appeared to be introduced during eye washing with contaminated water. Pseudomonal ulcers occurred most frequently in the monsoon season, and Fusarium cases were seen only in the hot, dry season. 相似文献
4.
深部病原真菌菌种4453株分析 总被引:1,自引:0,他引:1
目的 分析深部病原真菌菌种分布。方法 收集1991-2003年我院门诊及住院病人6533例,对其标本按真菌培养分离鉴定步骤进行鉴定。结果 分离出白念珠菌3555株(85.44%),克柔念珠菌309株(7.43%),高里念珠菌239株(5.74%);呼吸系统分离出真菌3004株(68.35%);消化系统真菌1291株(29.37%);泌尿生殖系统87株(1.98%);神经系统8株(0.18%);血液5株(0.11%)。结论 念珠菌属尤其白念珠菌是我院近13年间系统性真菌感染的重要致病菌;合理应用抗生素及早期诊断尤为重要。 相似文献
5.
一些损伤和疾病平时罕见,特殊情况下可以发生,造成严重危害。特殊情况主要包括严重事故、灾害、战争、恐怖主义活动以及特殊环境与特殊作业的危害等。本阐述了现代战争中发生的贫铀武器伤害、燃料空气炸弹伤害、微波武器伤害和战时精神疾病;可能源于恐怖主义活动的炭疽、天花;严重事故性伤害中的核事故、化学事故和煤矿事故伤害;严重灾害中的地震、海难(海战)落海伤害。中介绍了这些伤病的发生情况、伤害特点与医学救治。 相似文献
6.
The yeast spectrum of the 'tea fungus Kombucha' 总被引:1,自引:0,他引:1
7.
8.
河北磁县食管癌胃癌高发人群口腔真菌分布的调查 总被引:1,自引:0,他引:1
应用常规方法随机研究食管癌、胃癌高发的磁县人群547例的口腔真菌。结果:1.口腔真菌阳性率为68.4%,食管真菌阳性率为47.3%,前者显著高于后者(P<0.001)。2.口腔真菌以念珠菌、曲霉菌和青霉菌为主,食管真菌以曲霉菌、青霉菌和念珠菌占多数。3.口腔与食管内的产毒真菌差异无显著性意义(P>0.05)。本结果为进一步研究口腔真菌与上消化道癌及肿瘤的一级预防提供了依据。 相似文献
9.
Acute nonlymphatic leukemia among deck officers on coastal tankers: a report of two cases 总被引:2,自引:0,他引:2
Ralph I. Nilsson Jan Carneskog Bengt G. Jrvholm Rolf G. Nordlinder 《American journal of industrial medicine》1988,14(6):657-659
Deck officers on coastal tankers may be exposed to high concentrations of cargo vapors during loading and tank-cleaning operations. Two cases of acute nonlymphatic leukemia are described. Both men had worked as chief officers on coastal tankers transporting benzene and other petroleum products. 相似文献
10.
Frances M. Dewey David R. Twiddy Sarah I. Phillips Margaret J. Grose Peter W. Wareing 《Food and Agricultural Immunology》1992,4(3):153-167
A sensitive, specific, quantitative enzyme‐linked immunosorbent assay (ELISA) has been developed that can be used to determine the extent of mycelial growth of a sporulating thermophilic fungus, Humicola lanuginosa on the surface of rice grains. The assay employs a monoclonal antibody EC6, developed in a previous study, which does not recognize spores of the fungus. Using antigen‐coated wells, a direct linear relationship was established between dilutions of extracts from freeze‐dried mycelium (0.5 to 3 μg/ml) and absorbance values but to eliminate day‐to‐day variations it was found to be necessary to run a dilution series, prepared from stock freeze‐dried mycelium, with every test sample. The ELISA method was compared with conventional quantitative methods. Estimates of total mycelial length in freeze‐dried material by ELISA were found to be in the same order of magnitude as those determined by ergosterol and a theoretical calculation. The ELISA method also compared favourably with direct linear measurements (by photomicrography) of live mycelium present in aliquots from homogenates of a 1 cm2 plug taken from a plate but estimates of the latter by the dilution plate count method were much lower. In assays with inoculated rice grains, the quantitative ELISA method proved more sensitive than either the ergosterol method or direct plating of surface‐sterilized grains. The ELISA method also has the advantage of being highly specific and quick to conduct. 相似文献