米非司酮应用于子宫内膜异位症患者的疗效观察123例

目的探讨米非司酮应用于子宫内膜异位症的疗效。方法 123例子宫内膜异位症患者被随机分为实验组(n=63)和对照组(n=60),两组均给予手术治疗,实验组在手术治疗基础上给予米非司酮治疗方案。结果实验组总有效率为95.2%,痊愈率为84.1%,对照组总有效率为56.7%,痊愈率为43.3%,实验组效果显著优于对照组(P<0.01)。结论手术治疗联合米非司酮应用于高血压脑出血,能提高手术效果,降低复发率,值得在临床上应用和推广。     

米非司酮对妊娠中期胎儿心脏超微结构的影响

目的:探讨米非司酮对妊娠中期胎儿心脏超微结构的影响。方法:将计划引产孕妇随机分为两组:对照组(水囊组)10例,实验组(米非司酮+水囊)15例。实验组按孕龄分为实验Ⅰ组(10例,16~22周),实验Ⅱ组(5例,23~28周)。实验组口服米非司酮100mg,连服3天,行水囊引产,对照组只行水囊引产。胎儿娩出后取心肌组织进行样本制备,然后在电镜下观察组织的超微结构。结果:细胞肿胀、空化,细胞膜不完整,闰盘分离,部分细胞连接消失。细胞核多呈不规则形,核内染色质凝聚呈块状,部分细胞核空化,核周围可见脂褐素。大部分肌丝断裂,肌节结构消失,少数可辩残留肌节结构,其间可见少量核糖体,但各带结构不清。线粒体肿胀,高度空化,嵴断裂,细胞基质局部空化。毛细血管内皮细胞肿胀。心肌组织细胞的超微结构有改变,且孕龄越小,超微结构改变越明显。结论:米非司酮可以引发胎儿心脏的缺血缺氧性改变。     

三联药物治疗未破裂异位妊娠的临床研究

目的 :观察甲氨蝶呤(Methotrexate,MTX)、米非司酮(Mifepristron,Ru486)及中药三联用药治疗未破裂型异位妊娠的临床疗效。方法 :对171例未破裂型异位妊娠病人 ,按药物治疗方法不同分为两组进行对照研究 :A组使用MTX注射 +Ru486口服 +中药联合治疗。B组单独使用MTX注射治疗。测定法定期测定两组病人血HCG值以监测血HCG下降情况 ,测量异位妊娠包块三径线值以监测病灶包块缩小情况 ,同时观察临床症状持续时间、副反应发生率及总有效率。结果 :血HCG下降及病灶包块缩小A组较B组明显 ,差异有显著性(p<0 05,p<0 01);临床症状持续时间A组较B组短 ,差异有显著性(p<0 05);副反应发生率两组间无显著差异(p>0 05);A、B两组的总有效率分别为 :95 74%和71 43% ,A组较B组高 ,差异有显著性(p<0 05)。结论 :三联使用甲氨蝶呤、米非司酮及活血化瘀消包块杀胚的中药既有很强的杀胚功能 ,又能消除病灶包块 ,保留生育功能。三联药物联合治疗未破裂异位妊娠具有疗效肯定、安全     

米非司酮保守治疗异位妊娠30例疗效观察

应用米非司酮治疗早期异位妊娠30例，结果术非司酮组的治愈率76.67％．与MTX对照组对比无显著差异（P＞0．05）；米非司酮的治疗效果随治疗前血β-HCG的水平增加而递减，增加米非司酮总用量不能提高治愈率，对妊娠囊已形成的早期异位妊娠，药物保守治疗效果较差．     

Facilitation of ethanol consumption by intracerebroventricular infusions of corticosterone

Male Wistar rats bearing intracerebroventricular (ICV) cannulae and with simultaneous access to 6% ethanol and water were subjected to adrenalectomy (ADX) or sham surgery. ADX decreased ethanol intake. Starting a few days later, the animals received ICV infusions with 100 μg corticosterone acetate (CORT) with 2-to 3-day intervals for 2 weeks. ICV CORT, but not SC CORT at the same dose, restored ethanol consumption in ADX rats to preoperative levels, whereas vehicle infusions (propylene, glycol) did not. Adrenally intact animals, which normally consumed moderate amounts of ethanol (≈0.5 g/kg per day), also showed a robust effect of ICV infusions of CORT, whereas this facilitatory effect was not observed in high consumers (≈3.0 g/kg per day). The suppressive effect of ADX on ethanol intake was not reproduced by concurrent and repeated ICV infusions of intracellular mineralocorticoid (RU 28318) and glucocorticoid (mifepristone) receptor blockers. It is concluded that CORT stimulates alcohol consumption by acting in the brain, probably by way of neuronal membrane mechanisms.     

小水囊在小月份中期妊娠引产中的应用价值

目的探讨两种引产方法在小月份中期妊娠中的应用。方法40例年龄18．35岁，停经12．17wk，要求引产的病例随机分为两组各20例，分别用米非司酮配伍米索前列醇引产，米非司酮配伍米索加用小水囊联合引产终止妊娠。结果两种引产方法对比分析，从引产至临产时间、总产程、出血量及失败率、住院时间比较，差异有显著性，从清宫率和感染率方面比较，两组无显著差异。结论双米加用小水囊应用于小月份中孕引产是一种高效、安全、经济的引产手段，值得临床推广。     

B超在药物流产不全中的诊断价值

目的 :探讨B超在药物流产不全中的诊断价值及宫内残留胚胎物的超声图像特征。方法 :采用ALOKASSD5 0 0型超声诊断仪 ,对 94例米非司酮药流后阴道不规则出血的患者进行超声检查。结果 :胚胎残留物超声图像特征明显 ,阳性率为 77 66% ,与病理检查的符合率为 95 74%。结论 :B超检查能迅速、准确地诊断药流后宫内胚胎组织残留 ,为临床治疗提供可靠的依据。     

米非司酮治疗子宫肌瘤的剂量探讨

目的:探讨米非司酮治疗子宫肌瘤的剂量。方法:将81例确诊为子宫肌瘤的患者随机分成3组,Ⅰ组口服米非司酮25mg/d×3个月;Ⅱ组口服米非司酮12.5mg/d×3个月;Ⅲ组口服米非司酮6.25mg/d×3个月。结果:用药过程中3组肌瘤均有不同程度的缩小,贫血得以纠正,围绝经期可致绝经。结论:12.5mg/d剂量米非司酮连服3个月为一疗程的治疗方案,副反应轻,疗效与25mg/d组无显著差异,费用可以减少50％。     

Consequence of long-term exposure to corticosterone or dexamethasone on ethanol consumption in the adrenalectomized rat,and the effect of type I and type II corticosteroid receptor antagonists

The daily fluid intake of male Wistar rats with simultaneous access to 6% ethanol and water was determined during a baseline period (1 week), following adrenalectomy (1 week) and for 3 weeks following SC implantation of hormone pellets containing corticosterone (CORT) or dexamethasone (DEX). Ethanol consumption dropped during the first week of adrenalectomy (ADX) but increased again in the absence of hormone replacement to reach preoperative levels during the ensuing weeks. The CORT treatment, which produced plasma hormone levels similar to the 24-h mean concentration of adrenally intact rats, not only reversed the effect of ADX on alcohol consumption but also enhanced it to levels above those observed in intact rats. Water intake was not affected by the CORT treatment. DEX implants stimulated water intake, but did not enhance the drinking of ethanol. SC injections of RU 28318 (type I corticosterone receptor antagonist; 10 mg/kg) or mifepristone (RU 38486; type II receptor antagonist; 25 mg/kg) at the beginning and halfway through three daily, 6-h tests failed to affect ethanol drinking in adrenally intact rats or in ADX rats bearing CORT implants. Similarly, there was no effect of giving the two antagonists in combination. These results suggest that exogenous CORT can induce excessive alcohol intake in genetically unselected rats and that this facilitatory effect may be mediated by non-genomic cellular mechanisms.