Graves病硫脲类药物治疗所致甲减（附32例临床分析）

Ｇｒａｖｅｓ病硫脲类药物治疗所致甲减（附３２例临床分析）广东省广宁县人民医院内科（５２６３００）梁如庆广州军区广州总医院内分泌科王国华，林延德Ｇｒａｖｅｓ病（弥漫性甲状腺肿伴甲状腺功能亢进症）的治疗方面，鉴于多数患者对手术有顾虑，同位素碘治疗尚不能普...     

巩膜腔内硅胶球植入的临床研究(摘要)

我科在13例眼球摘除患者中应用改良的巩膜腔内硅胶球植入术的方法,装配义眼后,有一定活动度,患者容貌得到了满意的改善。报告如下。本组13例中男10例,女3例。年令10～60岁。眼球摘除原因:眼球萎缩6例,角膜葡萄肿2例,眼内炎4例,角膜瘘1例,材料选用国产硅橡胶球。常规行眼球内容物剜出术,将巩膜腔内处理干净后:(1)于巩膜缘3及9点处各做以缘为底的三角形切除;(2)植入硅胶球,丝线交叉贯穿硅胶球,缝合固定于巩膜内板层壁上,连续缝合巩膜;(3)交     

东菱克栓酶治疗急性脑梗塞100例疗效观察

我院于1994—10～1996—04应用东菱精纳克栓酶（DF—521）治疗急性脑梗塞100例，取得满意疗效报告如下。1临床资料1.1及一般资料本组100例均经CT或MRI确诊的急性脑梗塞患者，发病时间均为＜24h，随机分为两组：冲击用量组（简称冲击组）50例，男31例，女19例。年龄40一78岁，平均576岁。常规用量组（简称常规组）50例，男34例，女16例。年龄39一73岁，平均56．l岁、首选对照组50例，男27例，女23例，年龄45～78岁，平均57．2岁。1．2方法冲击组采用DF一521连续用药3天，首次20BU，第二、三次各10枷，用0．扔％生理盐水100W稀释，滴注时…     

脂氧素A4对心肌缺血再灌注损伤的保护作用

Objective To investigate the roles of lipoxin A4, an endegenous lipid mediator with wide anti-inflammatory fea- tures, in attenuating myocardial ischemia-reperfusion injury and the possible mechanisms. Methods Thirty male KM mice were divid- ed randomly into three groups, 10 in each: ischemia-reperfusion group (group A), lipoxin A4 (0.1 mg/kg) group (group B) and Zn- PP (Zinc protoporphyrin Ⅸ, 25 mg/kg)phus lipoxin A4 (0.1 mg/kg)group (group C). A ischemia-reperfusion heart model was de- veloped by ligating the lift anterior descending branch of the coronary artery. A dine of 10% dehydrated alcohol in 0.2 ml for group A, a dose of isochoric lipoxin A4 for group B and a dose of isochoric ZnPP + lipoxin A4 for group C was infused into the ascending aorta through a catheter, which was kpassing the right common carotid artery, 30 minutes after reperfusion. The concentration of serum TNF-α, activities of serum crestine kinase(CK) and lactate dehydrogenase (LDH), activities of myeloperoxidase (MPO) and malond- ialdehyde (MDA) and the cell apoptosis rate in the myocardial tissue were measured 5 hours after reperfusion. Pathological features of the inflammatory infiltration in the myocardium were also observated.Results As compared with group A, the inflammatoryry infiltra- tion in the ischemic and necrotic regions tithe myocardium was reduced, with group C in the intermediate range. The serum activities of CK and LDH wine significantly lower in group B and C than that in group A, and the lowest activities were detected in group B. Similar findings were observed for MPO, an indicator for neutrophil infiltration, and MDA, an indictor for cell injury caused by oxy- gen radicals, in the myocardium. The concentration of TNF-α and the rate of cadiocyte apoptosis were decreased significantly in group B(P < 0.01). ZnPP, an inhibitor of heine oxygenase (HO)-1, attenusted the above protective effects of lipoxin A4 significantly (P<0.05). Conclusion Lipoxin A4 has protective effects against myocardial ischemia-reperfusion injury, and HO-1 may have a potential role in the protectve mechanisms of lipoxin A4, probably pertly by means of reducing the production of reactive oxygen spe- cies and TNF-α, decreasing the activation and infiltration of neutrophils, alleviating inflammatory damage and avoiding apoptosis.     

自制幼儿口垫在临床胃镜检查中的作用

近年来，幼儿将硬币、游戏机币、钮扣等小物件吞入食管、胃内的病例时有发生。行胃镜取幼儿食管及胃内异物时。建立口通道常有困难，市售口垫直径过大，难以放入幼儿口部且质地过硬，容易对幼儿口唇造成损害，再就是长度过短，不能压住幼儿舌体。笔者从2001年用自制口垫很好地解决了这些问题。     

老年人高血压性脑出血急性期T淋巴细胞亚群的检测及初步探讨

老年人高血压性脑出血急性期Ｔ淋巴细胞亚群的检测及初步探讨王国华，张秀华，白颖哈市第一医院神经科王文宝哈市第一医院血液病研究所祁威，方俊兰哈市第十医院神经科自从１９７９年Ｒｅｉｎｈｅｒｚ获得淋巴细胞单克隆抗体以来，使人们对Ｔ淋巴细胞亚群及其临床意义逐渐...     

一种治疗翼状胬肉的新术式

翼状胬肉治疗方法很多,却很难有效控制其复发。笔者采用彻底切除翼状胬肉根部的方法,治疗146例,经长期随访观察,效果满意。报告如下。对象与方法1.对象:本文以门诊及住院的翼状胬肉患者134人(146眼)为治疗观察对象。男93人,女41人。年龄18—74岁。双眼发病12     

饮食服务业58241名从业人员HBV感染状况调查分析

目的　了解饮食服务业从业人员乙型肝炎病毒感染状况。方法　应用ELISA方法对 5 82 4 1名饮食服务业从业人员进行了血清HBsAg、抗 HBc、HBeAg和抗 HBe检测。结果　 2 0 0 0～ 2 0 0 4年饮食服务业从业人员血清HBsAg、抗 HBc、HBeAg和抗 HBe总阳性率呈逐年下降趋势 ,依次为 4 .39%、3. 85 %、3. 4 7%、2. 84 %和 2 4 3% ,其差异有统计学意义 (χ2 =88. 4 1,P <0 . 0 1) ,每间隔 1年及其以上的两个年度的阳性率之间的差异均有统计学意义(均P <0. 0 1)。结论　饮食服务业从业人员HBV感染率呈逐年下降趋势。