他克莫司联合308nm准分子激光治疗面部白癜风

目的探讨他克莫司联合308nm准分子激光在面部白癜风治疗中的应用效果。方法选取2017年2月-2019年2月医院84例面部白癜风患者为研究对象,根据入院单双号将受试者进行分组,其中对照组42例患者接受308nm准分子激光治疗,研究组42例患者在对照组的基础上联合他克莫司软膏治疗,比较两组患者治疗后1个月、3个月时的治疗总有效率以及治疗前后白斑面积与皮损区IL-17水平变化。结果研究组患者在治疗后1个月、3个月时的治疗总有效率均显著高于对照组(P<0.05),与治疗前相比,治疗后两组患者白斑面积及皮损区IL-17水平均显著减少,且研究组显著少于对照组(P<0.05)。结论他克莫司联合308nm准分子激光可有效缩小白斑面积,降低皮损区IL-17水平,疗效确切。     

脑瘫患儿发生癫痫持续状态的急救护理体会

目的对脑瘫患儿发生癫痫持续状态的急救护理方法和效果进行探讨。方法选择2018年4月—2018年9月在医院收治的50例脑瘫发生癫痫持续状态的患儿作为对照组,对其实施常规急救护理,同时选择2018年10月—2019年3月在医院收治的50例脑瘫发生癫痫持续状态的患儿作为观察组,对其实施强化急救护理,对比两组护理满意度、生命体征评分、护理有效率。结果观察组的总体满意率、护理有效率、生命体征评分均优于对照组,两组差异明显,有统计学意义,P<0.05。结论对脑瘫发生癫痫持续状态的患儿实施强化急救护理能够提升治护效果,提高患儿家长满意度,更好的改善患儿生命体征。     

Source imaging of seizure onset predicts surgical outcome in pediatric epilepsy

ObjectiveTo assess whether ictal electric source imaging (ESI) on low-density scalp EEG can approximate the seizure onset zone (SOZ) location and predict surgical outcome in children with refractory epilepsy undergoing surgery.MethodsWe examined 35 children with refractory epilepsy. We dichotomized surgical outcome into seizure- and non-seizure-free. We identified ictal onsets recorded with scalp and intracranial EEG and localized them using equivalent current dipoles and standardized low-resolution magnetic tomography (sLORETA). We estimated the localization accuracy of scalp EEG as distance of scalp dipoles from intracranial dipoles. We also calculated the distances of scalp dipoles from resection, as well as their resection percentage and compared between seizure-free and non-seizure-free patients. We built receiver operating characteristic curves to test whether resection percentage predicted outcome.ResultsResection distance was lower in seizure-free patients for both dipoles (p = 0.006) and sLORETA (p = 0.04). Resection percentage predicted outcome with a sensitivity of 57.1% (95% CI, 34–78.2%), a specificity of 85.7% (95% CI, 57.2–98.2%) and an accuracy of 68.6% (95% CI, 50.7–83.5%) (p = 0.01).ConclusionIctal ESI performed on low-density scalp EEG can delineate the SOZ and predict outcome.SignificanceSuch an application may increase the number of children who are referred for epilepsy surgery and improve their outcome.     

星点设计-效应面法优化丁香苦苷聚乳酸-羟基乙酸纳米粒的制备工艺

目的优化丁香苦苷聚乳酸(Syr)-羟基乙酸共聚物[poly(lactic-co-glycolic acid),PLGA]纳米粒(Syr-NPs)的处方。方法采用纳米沉淀法制备Syr-NPs,以包封率、载药量、平均粒径以及总评"归一值"为评价指标,采用星点设计-效应面法考察PLGA质量浓度(A)、丁香苦苷质量浓度(B)、水相与有机相比例(C)3因素考察对包封率、载药量、平均粒径以及总评归一值的影响,以星点设计-效应面法选取最佳处方条件进行预测分析。结果最优处方工艺为PLGA质量浓度为9.63 mg/mL,Syr质量浓度为12.88 mg/mL,有机相与水相的比例为1∶9.46,制得的Syr-NPs的包封率、载药量、平均粒径分别为(27.86±0.87)%、(7.02±0.15)%、(110.0±1.20)nm。结论该方法稳定可行,可用于优化包载Syr的PLGA纳米粒处方与制备工艺。     

力量支持协同护理模式在经口喂养不耐受<34孕周新生儿中的应用

目的:探讨力量支持协同护理模式在经口喂养不耐受<34孕周新生儿中的应用效果。方法:选取2019年1月—2020年8月收治的102例<34孕周经口喂养不耐受新生儿作为研究对象,将2019年1月—2019年10月接受常规护理的51例患儿作为对照组,将2019年11月—2020年8月接受力量支持协同护理模式的51例患儿作为观察组。比较两组经口喂养进程(留置胃管时间、过渡时间、住院时间)、喂养效率及患儿行为状态变化。结果:观察组患儿留置胃管时间、过渡时间、住院时间均短于对照组(P<0.05);观察组患儿干预第3天、实现全口喂养时吸吮效率和喂养效率均高于对照组(P<0.05);观察组患儿干预3 d、干预5 d后行为状态优于对照组(P<0.05)。结论:力量支持协同护理模式能有效改善早产儿经口喂养表现,减轻经口喂养不耐受症状,进一步推进经口喂养进程,缩短经口喂养过渡时间。     

175名综合医院助产士夜间工作效率现状及影响因素分析

目的 调查广西省综合性医院助产士夜间工作效率现状及其影响因素,旨在为助产士管理者采取有针对性的管理策略提供参考。方法 便利选取本地区6所医院的175名助产士,采用《助产士日间倦怠量表》、听觉词汇学习记忆测试法及技术测定法进行调查。结果 助产士夜间工作效率为(89.16±14.55)min；年龄小、无子女、学历高、产科工作时间短、职称低、夜班数多的助产士夜间工作效率较低(P<0.05)；助产士日间倦怠总均分为(14.72±2.44)分,记忆功能总均分为(28.62±4.07)分,助产士夜间间接工作效率总分与日间倦怠总分(r=-0.697,P=0.000)呈一定负相关；与记忆能力总分(r=-0.939,P=0.000)呈一定正相关。结论 助产士夜间工作效率偏低；日间倦怠、记忆能力是助产士夜间工作效率的主要影响因素。     

Clinical therapeutic effects of probiotics in combination with antibiotics on periodontitis: A protocol for systematic review and meta-analysis

Background:Dental pain can have a detrimental effect on quality of life. Symptomatic apical periodontitis is the most common cause of dental pain and arise from an inflamed or necrotic dental pulp. There is growing evidence to support the effectiveness of probiotics in combination with antibiotics on periodontitis. We therefor will conduct this study to evaluate the clinical therapeutic effects of probiotics in combination with antibiotics on periodontitis.Methods:We will systematically search the following databases: PubMed, the Cochrane Library, EMBASE, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese BioMedical Literature Database (CBM), and WanFang database. A grey literature search will be conducted using ZETOC Conference Proceedings and Open Grey. Only randomized controlled trials (RCTs) related to research on probiotics in combination with antibiotics to treatment patients with periodontitis will be included. All sources have to be searched from their inception to October 2020. Two authors will independently select studies, extract study data, and evaluate the quality of the included studies. We will use Review Manager Software (RevMan 5.3) to analyze data.Results:This study will systematically evaluate the clinical therapeutic effects of probiotics in combination with antibiotics on periodontitis.Conclusions:This study will generate evidence for a better clinical decision of patients with periodontitis.Registration number:DOI 10.17605/OSF.IO/QZ6SB (https://osf.io/qz6sb/).