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Vargas-Mendoza N Madrigal-Santillán E Morales-González á Esquivel-Soto J Esquivel-Chirino C García-Luna y González-Rubio M Gayosso-de-Lucio JA Morales-González JA 《World journal of hepatology》2014,6(3):144-149
The use of medicinal plants in treating illnesses has been reported since ancestral times.In the case of hepatic diseases,several species such as Silybum marianum,Phyllanthus niruri,and Panus giganteus(Berk.)have been shown to ameliorate hepatic lesions.Silymarin is a natural compound derived from the species Silybum marianum,which is commonly known as Milk thistle.This plant contains at least seven flavoligands and the flavonoid taxifolin.The hepatoprotective and antioxidant activity of silymarin is caused by its ability to inhibit the free radicals that are produced from the metabolism of toxic substances such as ethanol,acetaminophen,and carbon tetrachloride.The generation of free radicals is known to damage cellular membranes and cause lipoperoxidation.Silymarin enhances hepatic glutathione and may contribute to the antioxidant defense of the liver.It has also been shown that silymarin increases protein synthesis in hepatocytes by stimulating RNA polymerase I activity.A previous study on humans reported that silymarin treatment caused a slight increase in the survival of patients with cirrhotic alcoholism compared with untreated controls. 相似文献
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Aim
This research was conducted to obtain accurate information on the protective effects of Portulaca oleracea L. against hepatogastric diseases.Results
P. oleracea L. (Purslane) has traditionally been used for the treatment of hepatogastric diseases. However, the low number of research studies has shown that P. oleracea L. possesses protective effects against hepatotoxic agents. The safety of P. oleracea L. has been demonstrated in several clinical trials.Conclusion
Modern pharmacological studies have indicated the gastroprotective and hepatoprotective effects of P. oleracea L. by using in vivo and in vitro models. However, due to lack of information of its effects in humans, more studies should be conducted to confirm the efficacy of P. oleracea L. in humans. 相似文献3.
我国结核病负担较高,每年仅新发现的初复治病例即达98万[1],加上原患未治愈者,每年接受治疗的病例超过100万.抗结核治疗使用的一、二线药物均可引起不良反应,其中影响最大且发病率较高的为肝损害[2]. 相似文献
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