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排序方式: 共有433条查询结果,搜索用时 62 毫秒
1.
Joshua Demb Esther K. Wei Monika Izano Stephen Kritchevsky Helen Swede Anne B. Newman Michael Shlipak Tomi Akinyemiju Steven Gregorich Dejana Braithwaite 《Journal of Geriatric Oncology》2019,10(2):265-271
Objectives
We examined the association between three inflammatory markers (Interleukin (IL)-6, C-reactive protein (CRP), tumor necrosis factor (TNF)-α) and incident lung cancer using baseline, updated, and averaged inflammatory measures in older adults.Methods
We fitted multivariable Cox models to assess whether circulating levels of inflammation markers were associated with incident lung cancers in the Health Aging, Body and Composition (HealthABC) prospective cohort of 3075 older adults aged 70–79?years at baseline. IL-6 and CRP were measured biennially, whereas TNF-α was measured at baseline.Results
Baseline levels of IL-6 were significantly associated with incident lung cancer risk in a model that adjusted for age, gender, race, and site (Model 1) (Hazard RatioT3 vs. T1: 3.34, 95% Confidence Interval: 1.91, 5.85) and in a model adjusted for health factors linked to chronic inflammation (Model 2) (HR T3 vs. T1: 2.57, 95% CI: 1.41, 4.65). The associations observed in time-updated IL-6 (HR T3 vs. T1: 2.47, 95% CI: 1.43, 4.28), cumulatively averaged IL-6 (HR T3 vs. T1: 2.47, 95% CI: 1.43, 4.35), and baseline CRP levels (HR T3 vs. T1: 1.85, 95% CI: 1.11, 3.08) with incident lung cancer in Model 1 were not statistically significant in Model 2.Conclusions
Baseline CRP and IL-6 levels were associated with increased risk of lung cancer in Model 1 and both models, respectively. Chronic IL-6 inflammation, as quantified by repeated measures was associated with incident lung cancer in Model 1, but not Model 2. Further research is needed to understand the role of CRP and IL-6 in lung carcinogenesis. 相似文献2.
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The objective of this study was to complete a comprehensive evaluation of the nutritional composition, physicochemical properties and protein profile of three different whey protein concentrate ingredients enriched in α-lactalbumin (LAC). The LAC ingredients studied were manufactured using different enrichment approaches, namely membrane filtration (LAC-M), selective precipitation (LAC-P) and ion exchange (LAC-IE), and were compared to benchmark whey protein concentrate (WPC) and skim milk powder (SMP) ingredients with unaltered protein profile. The LAC ingredients had heterogeneous chemical composition and protein profile, which depended on the enrichment approach used. Protein profile of LAC ingredients was dominant in α-lactalbumin and therefore higher in tryptophan when compared to the benchmark ingredients. Unlike LAC-M and LAC-IE, LAC-P had a very complex protein profile. The new information provided by this study for these novel added-value whey protein ingredients will support the development of next-generation dairy-based formulated nutritional products. 相似文献
4.
Salaam Semaan 《Emerging infectious diseases》2016,22(10):1863-1864
5.
胆石的回声强度和化学成分关系的研究 总被引:1,自引:0,他引:1
目的:评价回声强度可否预测胆石的化学性质和结构特点。方法:62例胆石症患者进行B超检查,测量胆石的回声强度(EL)。以红外光谱仪定量分析所有胆石的四种主要化学成分。结果:EL《100(7例),101~140(22例),141~180(25例),》180(8例)。四组间胆固醇,胆红素及胆红素钙的含量无显著差异(P>005,但》180组中碳酸钙的含量显著高于其它三组。EL与碳酸钙的含量呈显著正相关(P<001,r=079),而与其它三种无相关。结论:EL可用于预测胆石的碳酸钙含量及钙化情况,但不能用于预测其它三种化学成分 相似文献
6.
《Néphrologie & thérapeutique》2021,17(6):441-450
To compare the chemical composition of the upper and lower urinary tract stones in Congolese patients, and to identify factors associated with the different types of stones. Stones from 119 patients originating from the upper tract and 75 from the lower tract were analyzed by infrared spectrophotometry. Among 119 patients with upper tract stones, age ranged from 10 to 81 years with a mean (SD) of 45.8 (13.6) years; males were the majority (55.5%). The main types of stones identified were whewellite (79%). For the 75 patients with lower apparatus stones, age ranged from 4 to 87 years with a mean (SD) of 51.6 (21.6) years; the majority were males (89.3%). The main types of stones were whewellite (44%) and anhydrous uric acid (22.7%). Overall, the factors associated with calcium oxalate included: site [4.95 (95% CI 2.35-10.44)] and diameter [3.03 (95% CI 1.45–6.25)]; patient's place of residence [0.05 (95% CI 0.01–0.29)] was associated with calcium phosphate. Infection stones were associated with; site [0.19 (95% CI 0.06–0.63)] and diameter [0.10 (95% CI 0.03–0.38)]. Finally, age 0.26 (95% CI 0.09–0.71) and stone site [0.23 (95% CI 0.07–0.68)] were associated with uric stones. The epidemiological and chemical profile of upper and lower tract stones were different. Several factors were associated with the chemical and crystalline composition of stones in the Democratic Republic of Congo. 相似文献
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8.
目的 探讨降低医疗费用的对策.方法 运用结构变动度和环比增长速度指标,分析2008年-2013年费用构成变动的情况.结果 费用构成变动比较合理,其他费和检查费是引起费用结构变动上升的主要费用项目,二者累积贡献率高达42.44%,护理费结构变动增幅较慢,仅为4.10%,说明在体现医生技术服务价值的同时,也应适当提高护理人员的技术服务价值,药品费、诊疗费、手术费是引起住院费用结构变动下降的主要费用项目,三者累积贡献率高达45.92%,说明了我院优化了收费结构,强化了管理意识.结论 优化医疗收入结构,有重点的控制主要因素,以较低的成本及合理收费,最大限度的满足患者医疗需求,实现医疗费用的理性回归. 相似文献
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