可能与链球菌感染有关的烟雾病一例报告

烟雾病是一种以颈内动脉(ICA)虹吸部进行性狭窄和大脑基底部异常血管网为特征的疾病,病因不明.最近,我们收治烟雾病儿童1例,可能与风湿热或链球菌感染有关,现报道如下.     

针刺太溪穴治疗脑卒中后吞咽障碍疗效观察

目的比较针刺太溪穴和头针治疗脑卒中引起假性球麻痹造成吞咽困难的疗效。方法将100例患者随机分为治疗组和对照组,每组50例。治疗组采用针刺太溪穴为主配合偏瘫治疗的基础针刺：对照组采用针刺头部的顶颞前、后斜线透刺为主配合偏瘫治疗的基础针刺。观察两组针刺3次、5次、10次的疗效并进行比较。结果治疗组和对照组总体疗效差异具有统计学意义（P〈0．05）：治疗组第3次治疗结束后的疗效优于对照组（P〈0．01）：但在第5次治疗结束，两组疗效差异无统计学意义。结论针刺太溪穴治疗脑卒中引起假性球麻痹造成吞咽困难疗效显著，起效较快，头针治疗累积效应更为明显。     

针刺治疗癔症性瘫痪1316例经验总结

癔症性瘫痪(以下简称癔瘫)是临床上较常见的疾患。我院自1957年3月至1984年9月采用针刺疗法,治疗癔瘫1316例,绝大多数患者经1～2次针刺治疗,患肢功能恢复正常,治愈率达97.8％。现将1316例癔瘫患者的临床资料、针刺方法和治疗中的经验体会总结如下。     

以反复面神经麻痹为表现的莱姆病1例

莱姆病是近期发现的一种螺旋体感染性疾病 ,极易侵犯人的神经系统 ,尤以面神经易受损 ,而面神经麻痹反复发作达三次的病例以往作者未见报道过 ,现将我们遇到的 1例报告如下 :患者 ,女性 ,34岁。缘于其 3岁时无明显诱因出现右眼闭合不全及口角向左偏斜就诊于我院 ,诊断为面神经炎 ,给予激素及Ｂ族维生素等药物治疗症状消失。于 1 6岁时再次出现类似发作 ,经治疗恢复正常。于 1 996年 1月 1 6日第 3次出现右眼闭合不全 ,口角向左偏斜而入院。病后无肢体无力症状 ,无发热 ,无皮肤红斑 ,否认蜱叮咬史。查体 :体温、脉搏、呼吸、血压正常 ,无皮疹…     

重型格林-巴利综合征1例

患者,男,34岁.因双上肢无力8 d加重1 d于2003年8月6日入院.患者于2003年7月29出现双上肢无力,伴肩部不适.2003年8月5日晨起出现视物成双,双上肢无力加重,伴言语不清.8月6日出现吞咽困难以"脑干病变"收住院.8月7日发热,体温39℃,服药后降至正常.     

针刺治疗吞咽困难31例疗效观察

针刺治疗吞咽困难３１例疗效观察（１０００９４）２６１医院癔瘫研究所王中铎袁玉民我们自１９９５年采用针刺治疗假性延髓麻痹引起的吞咽困难，现报道如下。１一般情况：本组３１例患者，男性２３例，女性８例，年龄５０～５９岁２８例，６０～７５岁３例。治疗前因吞咽...     

The Effect of Lumbrokinase on P-selectin and E-selectin in Cerebral Ischemia Model of Rat

Purpose:To find the effect of lumbrokinase(LK)on P-selectin and E-selectin in ischemic rats.Methods:Male healthy Spragur-Dawley rats weighing 180-220 g(n=90) were divided into 4 groups:(1)normalcontrol group(n=5),(2)sham-operated group(n=35),(3)ischemic group(n=35),(4)LK group(n=15).LK10mg/kg(2000UK activity of LK)was given by intraperitoneal injection in the LK group 30 minutes beforeexperiment.Same volume of normal saline was given in the sham-operated group and ischemic group.Theischemic model was made by modified Haruo Nagasawa's method.Immunohistochemistry was used toobserve the P-selectin and E-selectin positive cells in the ischemic region.Results:P-selectin and E-selectinpositive cells in ischemic regions were observed in the ischemic group,and the peak of expression was at 6hours and 12 hours,respectively.The similar changes were not observed in normal control group.Therewere only a few positive cells in the sham-operated group.In LK group,the P-selectin and E-selectinpositive cells were significantly less than those in the ischemic group(P<0.05 at 3 hours after the onset,P<0.01 at 6 hours and P<0.01 at 12 hours,respectively).Conclusions:LK might significantly decrease theimmunoreactions of P-selectin and E-selectin in ischemic lesion.     

吡那地尔对5—HT3受体介导的离体豚鼠回肠收缩反应的抑制

AIM: To study the effects of the K+ channel opener pinacidil on 5-HT3 receptor-mediated contractions of the isolated guinea pig ileum (GPI) longitudinal muscle-myenteric plexus strip preparations. METHODS: GPI contractions were recorded with a chart recorder through isometric transducers. The effect of pinacidil on binding properties of 5-HT3 receptors was assessed using [3H]GR65630 binding assay in membrane preparations of rat entorhinal cortex. RESULTS: (1) A selective 5-HT3 receptor agonist 2-methyl-5-HT 0.1-300 mumol.L-1 and 5-HT 0.001-50 mumol.L-1 elicited GPI contractile responses in concentration-dependent manners, the EC50 values (and 95% confidence limits) for 2-methyl-5-HT and 5-HT were 10.0 (8.9-11.2) mumol.L-1 and 1.6 (1.3-1.9) mumol.L-1, respectively. Selective 5-HT3 receptor antagonist tropisetron 0.1 mumol.L-1 competitively inhibited the responses to 2-methyl-5-HT and 5-HT. (2) Pinacidil 0.5-5 mumol.L-1 inhibited 5-HT3 receptor-mediated contractions. (3) Pinacidil 1 mumol.L-1 enhanced the inhibitory effects of tropisetron 0.1 mumol.L-1 or another selective 5-HT3 receptor antagonist benesetron 1 mumol.L-1 on 5-HT-induced GPI contractile responses. (4) Pinacidil 1-5 mumol.L-1 did not affect GPI contractile responses evoked by a selective M-ACh receptor agonist carbachol 1 mumol.L-1. (5) Pinacidil 1-5 mumol.L-1 had no effect on binding properties of 5-HT3 receptors with selective 5-HT3 receptor radioligand [3H]GR65630 in the entorhinal cortex of rat brain. CONCLUSION: The inhibition by pinacidil of 5-HT3 receptor-mediated GPI contractile responses may be mediated through activation of ATP-sensitive K+ channels located in prejunctional myenteric neurons.     

以脑膜炎、脑膜脑炎为首发表现的莱姻病6例

一般资料:6例病人,男5例、女1例;年龄20～72岁。6例病人均为急性起病。临床表现:头痛6例,恶心呕吐4例,发热、乏力不适各2例,精神异常2例。癫痫大发作1例,偏瘫1例,脑膜刺激征5例,1例同时伴有第3～7对颅神经受损。     

The Effect of Lumbrokinase on P-selectin and E-selectin in Cerebral Ischemia Model of Rat

PURPOSE: To find the effect of lumbrokinase (LK) on P-selectin and E-selectin in ischemic rats. METHODS: Male healthy Spragur-Dawley rats weighing 180-220 g (n = 90) were divided into 4 groups: (1) normal control group (n = 5), (2) sham-operated group (n = 35), (3) ischemic group (n = 35), (4) LK group (n = 15). LK 10 mg/kg (2000 UK activity of LK) was given by intraperitoneal injection in the LK group 30 minutes before experiment. Same volume of normal saline was given in the sham-operated group and ischemic group. The ischemic model was made by modified Haruo Nagasawa's method. Immunohistochemistry was used to observe the P-selectin and E-selectin positive cells in the ischemic region. RESULTS: P-selectin and E-selectin positive cells in ischemic regions were observed in the ischemic group, and the peak of expression was at 6 hours and 12 hours, respectively. The similar changes were not observed in normal control group. There were only a few positive cells in the sham-operated group. In LK group, the P-selectin and E-selectin positive cells were significantly less than those in the ischemic group (P < 0.05 at 3 hours after the onset, P < 0.01 at 6 hours and P < 0.01 at 12 hours, respectively). CONCLUSIONS: LK might significantly decrease the immunoreactions of P-selectin and E-selectin in ischemic lesion.