全文获取类型
收费全文 | 27972篇 |
免费 | 1966篇 |
国内免费 | 527篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 789篇 |
妇产科学 | 66篇 |
基础医学 | 883篇 |
口腔科学 | 13篇 |
临床医学 | 5804篇 |
内科学 | 13455篇 |
皮肤病学 | 18篇 |
神经病学 | 382篇 |
特种医学 | 773篇 |
外科学 | 2247篇 |
综合类 | 3579篇 |
现状与发展 | 1篇 |
一般理论 | 1篇 |
预防医学 | 345篇 |
眼科学 | 4篇 |
药学 | 1529篇 |
10篇 | |
中国医学 | 502篇 |
肿瘤学 | 53篇 |
出版年
2024年 | 13篇 |
2023年 | 483篇 |
2022年 | 563篇 |
2021年 | 1046篇 |
2020年 | 1085篇 |
2019年 | 1225篇 |
2018年 | 1122篇 |
2017年 | 674篇 |
2016年 | 609篇 |
2015年 | 775篇 |
2014年 | 1841篇 |
2013年 | 1541篇 |
2012年 | 1126篇 |
2011年 | 1412篇 |
2010年 | 1185篇 |
2009年 | 1129篇 |
2008年 | 1263篇 |
2007年 | 1342篇 |
2006年 | 1207篇 |
2005年 | 1127篇 |
2004年 | 908篇 |
2003年 | 816篇 |
2002年 | 725篇 |
2001年 | 758篇 |
2000年 | 614篇 |
1999年 | 617篇 |
1998年 | 564篇 |
1997年 | 573篇 |
1996年 | 450篇 |
1995年 | 418篇 |
1994年 | 401篇 |
1993年 | 334篇 |
1992年 | 334篇 |
1991年 | 297篇 |
1990年 | 265篇 |
1989年 | 183篇 |
1988年 | 194篇 |
1987年 | 176篇 |
1986年 | 183篇 |
1985年 | 158篇 |
1984年 | 177篇 |
1983年 | 120篇 |
1982年 | 108篇 |
1981年 | 76篇 |
1980年 | 67篇 |
1979年 | 55篇 |
1978年 | 41篇 |
1977年 | 16篇 |
1976年 | 27篇 |
1973年 | 18篇 |
排序方式: 共有10000条查询结果,搜索用时 46 毫秒
1.
《Saudi Pharmaceutical Journal》2022,30(6):669-678
BackgroundIschemia reperfusion (I/R) play an imperative role in the expansion of cardiovascular disease. Sinomenine (SM) has been exhibited to possess antioxidant, anticancer, anti-inflammatory, antiviral and anticarcinogenic properties. The aim of the study was scrutinized the cardioprotective effect of SM against I/R injury in rat.MethodsRat were randomly divided into normal control (NC), I/R control and I/R + SM (5, 10 and 20 mg/kg), respectively. Ventricular arrhythmias, body weight and heart weight were estimated. Antioxidant, inflammatory cytokines, inflammatory mediators and plasmin system indicator were accessed.ResultsPre-treated SM group rats exhibited the reduction in the duration and incidence of ventricular fibrillation, ventricular ectopic beat (VEB) and ventricular tachycardia along with suppression of arrhythmia score during the ischemia (30 and 120 min). SM treated rats significantly (P < 0.001) altered the level of antioxidant parameters. SM treatment significantly (P < 0.001) repressed the level of creatine kinase MB (CK-MB), creatine kinase (CK) and troponin I (Tnl). SM treated rats significantly (P < 0.001) repressed the tissue factor (TF), thromboxane B2 (TXB2), plasminogen activator inhibitor 1 (PAI-1) and plasma fibrinogen (Fbg) and inflammatory cytokines and inflammatory mediators.ConclusionOur result clearly indicated that SM plays anti-arrhythmia effect in I/R injury in the rats via alteration of oxidative stress and inflammatory reaction. 相似文献
2.
3.
Management of gestational supraventricular tachycardia with a ‘modified’ modified Valsalva manoeuvre
A 36 year old woman with chest pain and palpitations at 34 weeks gestation (gravidity 2, parity 1) presented to the emergency department where she was found to be in supraventricular tachycardia (SVT). This patient had an earlier episode of SVT during the same pregnancy that was managed with intravenous adenosine. During both presentations a REVERT trial style ‘modified’ Valsalva manoeuvre (including supine positioning with passive leg raise) was attempted without success. Acknowledging the potential for vena caval compression in pregnant patients while in the Trendelenburg position, the same manoeuvre was attempted with the novel additional of 45 degree left pelvic tilt. This ‘modified’ modified Valsalva was successful in restoring sinus rhythm, suggesting this technique may warrant further investigation as a viable treatment for pregnant patients with hemodynamically stable SVT. 相似文献
4.
5.
6.
《Revista portuguesa de cardiologia》2022,41(3):253-259
Left ventricular noncompaction (LVNC) is a genetically heterogeneous cardiomyopathy, with familial and sporadic forms, but genetic testing only identifies a pathogenic mutation in a minority of cases. The main complications are heart failure, embolism and dysrhythmias. Herein we report a familial case of LVNC associated with a mutation in the MYH7 gene and review the literature regarding controversies in LVNC. A 50-year-old woman was referred to the cardiology clinic for palpitations. She underwent echocardiography and cardiac magnetic resonance imaging that revealed mild left ventricular systolic dysfunction and LVNC criteria. She had several episodes of non-sustained ventricular tachycardia and received an implantable cardioverter-defibrillator (ICD). Genetic testing revealed the c.1003G>C (p.Ala335Pro) mutation in the MYH7 gene. Familial screening showed clear genotype-phenotype cosegregation, which provided strong evidence for the pathogenic role of this mutation. To the best of our knowledge, this is the first report of LVNC associated with the p.Ala335Pro mutation in the MYH7 gene. This mutation has been described in hypertrophic cardiomyopathy, suggesting that the same pathogenic sarcomere mutation may be associated with different cardiomyopathies. This case also highlights the current difficulties regarding decisions on ICD implantation for primary prevention of sudden cardiac death in LVNC. 相似文献
7.
8.
9.
10.