排序方式: 共有38条查询结果,搜索用时 15 毫秒
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Novakovic J Nesmerak K Nova H Filka K 《Journal of pharmaceutical and biomedical analysis》2001,25(5-6):957-964
A high-performance thin-layer chromatographic method (HPTLC) has been developed for the determination and the purity control of a synthetic fluoroquinolone antibiotic ciprofloxacin hydrochloride in coated tablets when desfluoro compound, ethylene diamine compound, by-compound A and fluoroquinolonic acid are considered as impurities. Silica gel F254 was used as a stationary phase and a mixture of acetonitrile, ammonia 25%, methanol and methylene chloride (1:2:4:4, v/v/v/v) as a mobile phase. The method was validated in terms of linearity (range), selectivity (placebo and related compounds), precision, accuracy (Recovery), system suitability (repeatability, peak symmetry, resolution) and impurities limit of detection (LOD). The analysis of variance (ANOVA) and t-test were applied to correlate the results of ciprofloxacin hydrochloride determination in coated tablets by means of the HPTLC method and the official British Pharmacopoeia (BP 1999) high-performance liquid chromatographic (HPLC) method. 相似文献
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《Statistics In Biopharmaceutical Research》2013,5(3):323-327
Sample size formulas are functions of two categories of quantities. The first category does not depend on the analysis variables and contains randomization ratio, Type I error rate, and power. The second category depends on the analysis variables and includes means and standard deviations for the two-sample t-test, competing probabilities for the Wilcoxon–Mann–Whitney test, and median survival times for the logrank test. Quantities in the second category depend on subject matter knowledge and are much harder to specify than those in the first category. In addition, these quantities have different interpretations. In this article we propose using the competing probability as the only second category quantity when calculating sample sizes for the aforementioned three commonly used tests in clinical trials. Doing so unifies the interpretation of and sheds new light on the two-sample t-tests and the logrank tests in terms of sample size calculations. 相似文献
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目的定期检测数字减影血管造影(DSA)设备的主要性能指标,并从检测数据中得出规律性因素,从而保证设备的良好性能。方法选取同一厂家相同型号的两台DSA,按照我院2007《中国人民解放军总医院DSA质量检测技术规范》进行质量检测,并对其检测数据运用独立样本t验统计分析。结果两台DSA设备由于所处工作负荷状态不同,其空气比释动能率、管电压精度等检测项目差异有统计学意义(P〈0.01)。结论质量检测是质量控制的重要环节,通过对检测数据进行统计分析,有助于评估设备运行的实际工作状态,并及时发现问题,有针对性的处理解决。 相似文献
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Michael H. Ames 《Journal of biopharmaceutical statistics》2013,23(2):177-183
Scheffe gave an exact solution to the problem of comparing two means from normal populations with unequal variances that is useful for general analysis of variance problems. The behavior of the usual t-statistic that assumes equal variances is contrasted to Satterthwaite's approximate t- statistic and Scheffe's method. An interesting relationship is uncovered between Scheffe's and Satterthwaite's solutions. 相似文献
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目的:测定黄连不同姜制品中6种生物碱的含量,采用多种统计方法对数据进行分析,找出姜制工序中影响姜黄连质量的因素。方法:采用高效液相色谱法测定黄连不同姜制品中药根碱、非洲防己碱、表小檗碱、黄连碱、巴马汀及小檗碱的含量。运用主成分分析、聚类分析、LSD(Least-Significant Difference)检验、独立t检验对结果进行分析。结果:黄连经姜炙后,表小檗碱、黄连碱含量略有上升,药根碱、非洲防己碱、巴马汀、小檗碱含量略有下降,传统姜炙品中各成分含量均高于烘制品。聚类分析发现榨汁组和煮汁组可以聚为一类;烘法和炙法具有明显不同的聚类,对黄连姜制品中的6种生物碱之和进行LSD检验,亦表明烘法与炙法具有显著性差异。对榨汁组进行独立t 检验,结果表明姜汁与黄连饮片拌匀或闷润至透心在6种生物碱上无显著性差异,LSD与独立t 检验的结果与聚类分析的结果一致。结论:采用同一批次黄连炮制所得的姜制品中,姜的来源、不同方法制备的姜汁及闷润过程对6种生物碱影响不大,加热方式可能是影响姜黄连质量的因素。考虑到润至透心需加入大量水稀释姜汁,炒干所需工时较长,故辅料姜汁与黄连饮片拌匀吸尽即可。 相似文献
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本研究利用相关分析与独立样本t检验对三种型号的高频电刀电气安全数据进行统计分析,验证各检测参数之间的关系及不同品牌参数间的差异。结果表明,地线出现故障时的对地漏电流会以其他方式或通过其他路径流入大地;对地漏电流、外壳漏电流、患者漏电流及患者辅助漏电流之间相互影响,相互作用。 相似文献
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