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排序方式: 共有665条查询结果,搜索用时 15 毫秒
1.
采用放射免疫方法测定了31例大肠癌、13例非肿瘤者血清标本和20例大肠癌组织、邻近肿瘤(〈3cm)及远离肿瘤(5cm)之结肠粘膜组织匀浆标本中的胃泌素浓度。发现:Dukes C.D期大肠癌病人血清胃泌素显著高于非肿瘤者(P〈0.05);血清胃泌素浓度与病程进展呈显著正相关(P〈0.05);直肠癌病人血清胃泌素显著高于非肿瘤(P〈0.05);血清胃泌素水平与肿瘤分化程度无关;肿瘤切除后血清胃泌素显著 相似文献
2.
B. Tarquini M. Cecchettin A. Cariddi 《International archives of occupational and environmental health》1986,58(2):99-103
Summary Gastrointestinal complaints, including peptic ulcer, are believed to be associated and enhanced by shift work (SW). However, there are no clear reports in the literature about this acquired pathology. Serum gastrin (G) and group I pepsinogen (PG1) are thought to play a role in the pathogenesis of peptic ulcer and may be considered a useful test of the gastric function. Five adult male foundry shift workers, without any demonstrated gastrointestinal pathology, were studied over a month's span during the following weekly rotating shift schedule: 07.45–16.45, 06.00–14.00, 14.00–22.00, 22.00–06.00. Six adult, day-working males acted as controls. Blood samples drawn at the beginning and at the end of each weekly shift were assayed for G and PG1 utilizing RIA kits. Our data showed that SW causes a prominent change in the gastrin/acidopepsin secretion system. 相似文献
3.
采用组织芯片技术分析胃癌组织中胃泌素和胃泌素释放肽的表达 总被引:4,自引:0,他引:4
目的研究胃癌组织中胃泌素(GAS)、胃泌素释放肽(GRP)的表达及其临床意义。方法采用组织芯片技术制作60例胃癌组织芯片,同时用生物素-链霉菌卵白素检测系统(SP)免疫组织化学方法检测胃癌组织芯片中GAS、GRP的表达。结果60例胃癌中GAS阳性率为30.0%;GRP阳性率为11.7%。中、低分化胃癌GAS、GRP阳性率高于高分化胃癌(P<0.05);印戒细胞癌GAS、GRP阳性率显著高于其他组织学类型胃癌(P<0.05);胃癌GAS、GRP阳性表达与淋巴结转移相关(P<0.05)。结论应用组织芯片大规模高效检测临床组织样本是可行的,具有快速、方便、经济、准确的特点。 相似文献
4.
观察大鼠小肠广泛切除术后血清胃泌素和结肠粘膜代偿性改变的动态变化规律,发现术后14天内血清胃泌素稍低于正常组,从第14天开始血清胃泌素升高加快,至21天时差异有显著性意义(P<0.05),第28天时差异有非常显著性意义(P<0.01).血清胃泌素变化与术后结肠粘膜DNA、RNA变化呈正相关关系(P<0.001),提示高胃泌素血症可能是引起小肠广泛切除术后结肠粘膜代偿性变化的主要因素之一. 相似文献
5.
The effects of cysteamine on the upper gastrointestinal tract of children with cystinosis 总被引:1,自引:0,他引:1
The purpose of this study was to evaluate the effects of cysteamine on gastric acid output and serum gastrin levels in children
with nephropathic cystinosis. We studied four children with nephropathic cystinosis receiving a dose of free base cysteamine
of 14.35 mg/kg four times a day (range 12.30 – 18.80 mg/kg). Gastric acid was measured for the hour before and after administration
of the medication. Serum gastrin levels were obtained at 0, 30, 60, and 90 min following the medication. Gastrointestinal
anatomy was evaluated by endoscopy and biopsy. Following administration of the medication, all subjects showed an increase
in gastric acid output. Mean acid output increased from 0.79 to 2.22 mEq/h. Mean gastric acid output adjusted for body weight
increased from 0.03 to 0.09 mEq/kg per hour. Following administration of the medication, all subjects showed an increase in
serum gastrin. The mean increase above the base value was 38.3 pg/dl. Two of the four subjects demonstrated visual and histological
evidence of inflammation. Cysteamine has a marked effect on gastric acid production and serum gastrin, even at the dose used
in children with nephropathic cystinosis. The clinical effect of this acid production is unknown but may be significant.
Received February 13, 1996; received in revised form February 25, 1997; accepted February 27, 1997 相似文献
6.
Oxytocin treatment in rats induces long-lasting antistress and growth promoting effects. This study investigated whether prolyl-leucyl-glycinamide (PLG) (the c-terminal tripeptide of oxytocin) or tocinoic acid (the ring structure of oxytocin) could induce some of these effects in male rats. For this purpose, PLG (2 or 10 mg/kg, s.c.) or tocinoic acid (1 mg/kg, s.c.) was administered to rats once a day for 3 or 5 days. Blood pressure, heart rate, spontaneous motor activity, nociceptive thresholds, and the survival of ischaemic musculocutaneous flaps were measured. In addition, endogenous oxytocin levels and plasma levels of some hormones known to be influenced by oxytocin were determined. PLG (2 mg/kg, s.c., but not 10 mg/kg, s.c.) decreased diastolic blood pressure (p<0.05) and locomotor activity (p<0.05). PLG (10 mg/kg, s.c.) decreased gastrin (p<0.05) and endogenous oxytocin levels in plasma (p<0.01). Tocinoic acid decreased locomotor activity (p<0.05), but did not affect any of the other parameters measured. In conclusion, this study showed that both PLG and tocinoic acid decrease locomotor activity. In addition, PLG also induced some other effects similar to those induced by oxytocin treatment but when administered in high doses it decreased oxytocin levels. 相似文献
7.
Lee CT Kuo BI Chen CY Chang FY Lee SD 《European journal of clinical pharmacology》1999,54(11):817-820
Objective: To determine which demographic factors may influence serum gastrin and pepsinogen I (PGI) levels in duodenal ulcer patients
undergoing omeprazole treatment.
Methods: We conducted an outpatient-based prospective study in the Veterans General Hospital, Taipei, to investigate the pharmacological
effects on patients with duodenal ulcers receiving omeprazole treatment for 4 weeks. Sixty-eight patients (61 males/7 females,
aged 25–73 years) with endoscopically confirmed duodenal ulcer were included. Gastrin and pepsinogen I levels were measured
before and after treatment. Demographic factors including age, sex, smoking, ulcer healing and antral Helicobacter pylori colonization/clearance were analyzed, in order to measure their probable influences on serum gastrin and pepsinogen I levels.
Results: Ulcer healing was seen in 92.6% of patients while 48 (70.6%) antral clearances were seen in 66 H. pylori colonized patients at the end of trial. Omeprazole monotherapy led to a marked elevation of serum gastrin (85.8 pg · ml−1, SD 32.0 pg · ml−1 vs 133.9 pg · ml−1, SD 71.6 pg · ml−1, P < 0.01), and pepsinogen I (111.0 ng · ml−1, SD 36.7 ng · ml−1 vs 253.6 ng · ml−1, SD 64.8 ng · ml−1, P < 0.01) levels when measured on day 29. Only patients showing antral H. pylori clearance exhibited an influence on the magnitude of pepsinogen I elevation following omeprazole monotherapy (143.9%, SD
67.3% vs 78.6%, SD 51.2%, P < 0.01). Moreover, the sensitivity and specificity of serum pepsinogen I variations were plotted on a receiving operating
characteristic (ROC) curve. The 140% increased pepsinogen I level yielded a maximum accuracy of 80% specificity or 50% sensitivity
to predict antral H. pylori clearance.
Conclusion: Antral H. pylori clearance is at least partially responsible for the omeprzaole-induced hyperpepsinogenemia I. The magnitude of hyperpepsinogenemia
I probably provides a non-invasive alternative for predicting H. pylori clearance.
Received: 22 August 1996 / Accepted in revised form: 1 October 1998 相似文献
8.
目的了解慢性肺源性心脏病(简称肺心病)患者PaCO2与血清胃泌素水平及幽门螺杆菌的关系,探讨肺心病合并上消化道出血的原因。方法观察组肺心病患者44例均符合1977年全国肺心病会议制定的诊断标准。对照组42例为随机选取的健康成人,两组性别、年龄无差异。PaCO2由本院血气分析室用nova-3型仪器测定,同时测定患者血清胃泌素,由首都医科大学临床检测中心运用放射免疫方法专人测定,用C13呼气实验(C-UBT)检测幽门螺杆菌的感染情况。全部数据以均值±标准差表示(x±s),均数差别显著性以t检验及逐步回归测算确定PaCO2与血清胃泌素及幽门螺杆菌的关系。结果肺心病组与对照组PaCO2、血清胃泌素及幽门螺杆菌两组对照有极显著性差异(P<0.001)。结论肺心病患者血清胃泌素水平较正常人明显升高,且幽门螺杆菌的感染率明显升高,与PaCO2呈正相关,易于并发上消化道出血。 相似文献
9.
大肠癌和癌旁粘膜中胃泌素,生长抑素变化的研究 总被引:1,自引:0,他引:1
临床观察大肠癌和癌旁粘膜中胃泌素,生长抑素及其分泌细胞的变化 ,探讨病人体内胃泌素、SS变化的原因和意义。方法:采用放射免疫法测定26例大肠癌病人肿瘤和癌旁粘膜中胃泌素,生长抑素水平,并对其分泌细胞行免疫细胞化学观察。 相似文献
10.
目的观察早产儿不同食物早期微量管饲时促胃液素及胃肠道功能变化。方法将33例早产儿随机分为糖水组、牛奶组,分别管饲5%葡萄糖和早产儿奶,每次喂养2 m l/kg,q3h,每12h增加1 m l/kg,同时予静脉营养。糖水组喂养3 d后逐渐添加早产儿奶。分别于喂养前、喂养后d 1、d 3、d 7测空腹血促胃液素(gastrin,Gas),比较血促胃液素、喂养不耐受发生率及达全肠道喂养时间。结果血Gas:糖水组加奶前各时段差异无显著意义(P>0.05);牛奶组逐日增高,同时牛奶组较糖水组明显增高(P<0.05)。喂养不耐受率:牛奶组较糖水组明显降低(P<0.05)。达全肠道喂养时间:牛奶组明显短于糖水组(P<0.05)。结论早期微量管饲时,奶汁能更好地促进Gas分泌,促进胃肠道成熟。 相似文献