全文获取类型
收费全文 | 22544篇 |
免费 | 2729篇 |
国内免费 | 635篇 |
专业分类
耳鼻咽喉 | 435篇 |
儿科学 | 395篇 |
妇产科学 | 336篇 |
基础医学 | 4382篇 |
口腔科学 | 1193篇 |
临床医学 | 2033篇 |
内科学 | 4451篇 |
皮肤病学 | 437篇 |
神经病学 | 1496篇 |
特种医学 | 350篇 |
外国民族医学 | 1篇 |
外科学 | 2059篇 |
综合类 | 2115篇 |
现状与发展 | 7篇 |
预防医学 | 870篇 |
眼科学 | 657篇 |
药学 | 3003篇 |
6篇 | |
中国医学 | 1082篇 |
肿瘤学 | 600篇 |
出版年
2024年 | 28篇 |
2023年 | 554篇 |
2022年 | 522篇 |
2021年 | 1225篇 |
2020年 | 1126篇 |
2019年 | 1133篇 |
2018年 | 1104篇 |
2017年 | 1112篇 |
2016年 | 1144篇 |
2015年 | 1241篇 |
2014年 | 1539篇 |
2013年 | 2578篇 |
2012年 | 1215篇 |
2011年 | 1358篇 |
2010年 | 1143篇 |
2009年 | 1107篇 |
2008年 | 1065篇 |
2007年 | 1093篇 |
2006年 | 933篇 |
2005年 | 732篇 |
2004年 | 674篇 |
2003年 | 508篇 |
2002年 | 441篇 |
2001年 | 332篇 |
2000年 | 257篇 |
1999年 | 261篇 |
1998年 | 206篇 |
1997年 | 159篇 |
1996年 | 153篇 |
1995年 | 144篇 |
1994年 | 96篇 |
1993年 | 113篇 |
1992年 | 84篇 |
1991年 | 68篇 |
1990年 | 45篇 |
1989年 | 52篇 |
1988年 | 47篇 |
1987年 | 38篇 |
1986年 | 36篇 |
1985年 | 41篇 |
1984年 | 51篇 |
1983年 | 31篇 |
1982年 | 24篇 |
1981年 | 27篇 |
1980年 | 17篇 |
1979年 | 13篇 |
1978年 | 11篇 |
1977年 | 7篇 |
1976年 | 10篇 |
1975年 | 5篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
《Revista brasileira de otorrinolaringologia (English ed.)》2022,88(4):621-624
ObjectivesRecurrent Aphthous Stomatitis (RAS) a chronic idiopathic oral mucosal disease. But yet the etiology and pathogenesis of RAS are not exactly known, it is thought that inflammation play an important role in the pathogenesis. The aim of this study is to demonstrate the role of systemic inflammation among the possible etiological factors of RAS and to find the possible diagnostic correlation between Systemic Immune Inflammation Index (SII).MethodsPatients who were consulted the otolaryngology outpatient clinic and diagnosed with RAS between 2019–2021 were retrospectively analyzed. Neutrophil/Lymphocyte Ratio (NLR), Platelet/Lymphocyte Ratio (PLR) and SII values were calculated based on the results of complete blood count. Demographic and hematological parameters between control and RAS groups were compared. The statistical significance level was considered as <0.05.ResultsThere was no statistically significant difference between the control and RAS groups in terms of sex and age distributions (p = 0.566 and p = 0.173, respectively). SII, NLR and PLR values were significantly higher in the RAS group compared to the controls (p < 0.001, p < 0.001 and p = 0.001, respectively). A very strong correlation between SII and NLR, moderately strong correlation between SII and PLR and moderate correlation between NLR and PLR values were detected (respectively ρ: 0.813, 0.719, 0.532; p-values <0.001).ConclusionSII, NLR and PLR has significantly higher levels in the RAS group compared to the control group, that it supports the role of systemic inflammation in the etiopathogenesis of RAS. In addition, the results show that SII is a valuable marker for inflammation.Level of evidence4. 相似文献
3.
Defects of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) protein affect the homeostasis of chloride, bicarbonate, sodium, and water in the airway surface liquid, influencing the mucus composition and viscosity, which induces a severe condition of infection and inflammation along the whole life of CF patients. The introduction of CFTR modulators, novel drugs directly intervening to rescue the function of CFTR protein, opens a new era of experimental research. The review summarizes the most recent advancements to understand the characteristics of the infective and inflammatory pathology of CF lungs. 相似文献
4.
5.
6.
7.
膳食炎症指数(DII)来源于将饮食和炎症联系起来的文献,被开发用来量化饮食的整体炎症潜能。饮食在调节慢性炎症中起着核心作用,是重要的调节因子,如果饮食的炎症潜能很高,则能够激发免疫调节作用,引起慢性炎症。DII可用于评估和指导个人饮食计划。本研究收集国外相关文献,就DII与炎症之间的相关性予以综述,以期通过减少饮食中的炎性成分而对慢性炎症引起的相关疾病进行一级预防。 相似文献
8.
Erik de Bakker Mirthe A. M. van der Putten Martijn W. Heymans Sander W. Spiekstra Taco Waaijman Liselotte Butzelaar Vera L. Negenborn Vivian K. Beekman Erman O. Akpinar Thomas Rustemeyer Frank B. Niessen Susan Gibbs 《Experimental dermatology》2021,30(1):169-178
Unpredictable hypertrophic scarring (HS) occurs after approximately 35% of all surgical procedures and causes significant physical and psychological complaints. Parallel to the need to understanding the mechanisms underlying HS formation, a prognostic tool is needed. The objective was to determine whether (systemic) immunological differences exist between patients who develop HS and those who develop normotrophic scars (NS) and to assess whether those differences can be used to identify patients prone to developing HS. A prospective cohort study with NS and HS groups in which (a) cytokine release by peripheral blood mononuclear cells (PBMC) and (b) the irritation threshold (IT) after an irritant (sodium lauryl sulphate) patch test was evaluated. Univariate regression analysis of PBMC cytokine secretion showed that low MCP‐1, IL‐8, IL‐18 and IL‐23 levels have a strong correlation with HS (P < .010‐0.004; AUC = 0.790‐0.883). Notably, combinations of two or three cytokines (TNF‐a, MCP‐1 and IL‐23; AUC: 0.942, Nagelkerke R2: 0.727) showed an improved AUC indicating a better correlation with HS than single cytokine analysis. These combination models produce good prognostic results over a broad probability range (sensitivity: 93.8%, specificity 86.7%, accuracy 90,25% between probability 0.3 and 0.7). Furthermore, the HS group had a lower IT than the NS group and an accuracy of 68%. In conclusion, very fundamental immunological differences exist between individuals who develop HS and those who do not, whereas the cytokine assay forms the basis of a predictive prognostic test for HS formation, the less invasive, easily performed irritant skin patch test is more accessible for daily practice. 相似文献
9.
10.
Peng Zhong Jianye Peng Mingjie Yuan Bin Kong He Huang 《Scandinavian journal of immunology》2021,93(1)
Cold‐inducible RNA‐binding protein (CIRP) was previously identified as an intracellular stress‐response protein, which can respond to a variety of stress conditions by changing its expression and regulating mRNA stability through its binding site on the 3′‐UTR of its targeted mRNAs. Recently, extracellular CIRP (eCIRP) was discovered to be present in various inflammatory conditions and could act as a pro‐inflammatory factor. Genetic studies have demonstrated a key role for eCIRP in inflammatory conditions that led to the importance of targeting eCIRP in these diseases. Currently, the underlying mechanism of eCIRP‐induced inflammation is under intensive investigation and several signalling pathways are being explored. Here, we epitomized various signalling pathways that mediate the pro‐inflammatory effects of CIRP and also recapitulated all the CIRP‐derived peptides that can block the interaction between CIRP and its receptors in inflammatory setting. 相似文献