MicroARN: la biología molecular como herramienta de predicción en preeclampsia

Preeclampsia is a disease with a significant incidence worldwide that is directly associated with 15% of maternal deaths. This is usually characterized by the presence of hypertension and proteinuria, which manifests itself from the middle of pregnancy. MicroRNAs are single-stranded RNA molecules that act primarily by degrading transcribed messenger RNA or inhibiting microRNA translation. Placental microRNAs play a role in the growth and function of the placenta, their potential use as diagnostic biomarkers is considered feasible due to the ability to enter the maternal circulation and be detectable in maternal plasma.     

搞好"病原生物学"教学及促进学科发展的实践与体会

将“医学微生物学”和“人体寄生虫学”整合为“病原生物学”符合现代医学教育的取向。中国医科大学是将两个教研室从形式到实质性合并为“病原生物学”教研室，并且将两门课完全融合成一门课程和一套教师队伍进行教学的少数院校之一。本文总结了在这一新学科教学和促进学科发展中的经验和体会。     

Marine biodiversity as a source of chemical diversity

Total global biodiversity is estimated at between 3 and 500 × 10⁶ species of prokaryote and eukaryote organisms spread across 70 or more phyla. The marine macrofauna alone are estimated between 0.5 and 30 × 10⁶ species and represents a broader range of taxonomic diversity than that found in the terrestrial environment, which has been the traditional source of natural products. With a typical eukaryote possessing 50,000 genes, the global marine macrofauna are the source of 2.5 × 10¹⁰ to 1.5 × 10¹² primary products and an associated extensive range of secondary products. However, only a few thousand novel compounds from marine organisms have been described. These compounds have proven unique in chemical and pharmacological terms but, as yet, no therapeutic agents have resulted. Given a broader drug discovery strategy, and facilitated by technological advances, it is predicted that the characterisation of marine chemical diversity will be accelerated. Strategies for drug discovery from the virtually untapped chemical diversity of marine organisms are discussed. © 1994 Wiley-Less, Inc.     

海生多糖肽对亚急性辐射损伤小鼠的防护作用

目的 研究海生多糖肽对小鼠亚急性辐射损伤的防护作用。方法 给小鼠饲以海生多糖肽制剂，用^60Coγ射线进行全身性亚急性照射，检测外周血白细胞、脾淋巴细胞转化率、红细胞超氧化物歧化酶、丙二醛和过氧化酶含量、精子畸形率、睾丸精母细胞染色体畸变率和肝细胞半胱氨酸蛋白酶-3等指标。结果 海生多糖肽高、低剂量组小鼠的血白细胞数量、脾淋巴细胞转化率、红细胞超氧化物歧化酶值和过氧化酶值均高于照射对照组，红细胞丙二醛值、精子畸形率、睾丸精母细胞染色体畸变率和肝细胞半胱氨酸蛋白酶-3阳性表达率则低于照射对照组，差异有显著性。结论 海生多糖肽对亚急性辐射损伤有良好的防护作用。     

Prognostic Factors in Elderly Patients with Acute Myeloid Leukaemia

Acute myeloid leukaemia (AML) is predominantly a disease of the elderly; the median age of incidence is 64 years, and 60% of all cases are over 60. With improved chemotherapy regimens and maximal supportive care, remission rates of up to 60% may be achieved in selected elderly patients. Whilst intensive chemotherapy is the treatment of choice for fit patients, it may be inappropriate for debilitated patients with poor prognosis disease in whom supportive care or palliative chemotherapy may be more suitable. AML in the elderly exhibits biological differences from AML in younger patients, and elderly patients may be unable to withstand the rigors of the intensive treatment regimens given to younger patients.     

头低位限制活动对家兔主要脏器微血管壁通透性的影响

本文报导了用40只白色短毛家兔所做的动物模拟失重实验,得出各脏器微血管通透性的动态反应曲线。并用微循环研究方法,分析了模拟失重时各脏器微血管功能状态与微血管通透性之间的关系;阐述了各脏器微循环功能变化特点;并对变化机理作了初步探讨。     

白色念珠菌感染的分子生物学诊断研究进展

综述了白色念珠菌感染的分子生物学诊断研究进展，包括核型分析，限制性片段长度多态性分析，特异的ＤＮＡ探针及ＰＣＲ等方法。     

采用基因配型行同种异体肾移植术

目的 探讨基因配型技术在同种异体肾移植中的应用。方法采用顺序特异引物聚合酶链反应法(PCR-SSP)分别进行供、受体的基因分型，为3例配型适当的终末性肾病患者行同种异体肾移植术，并观察其术后肾功能恢复情况。结果所有接受肾移植的患者于术后2d肾功能恢复至正常水平，无急性和超急性排异发生。随访11-15个月，各项检查指标均正常。结论 基因配型的准确率较之传统的血清学配型显著增加，显著提高同种异体肾移植的成功率。     

日照市冷库海产品挥发性盐基氮指标调查

１９９６年１～２月份调查了全市３０个冷库１３１份海产品，１２７份挥发性盐基氮指标符合国家卫生标准，合格率为９６．９５％。说明仍有极少的海产品有腐败变质现象，为保证消费者食用安全，建议每月检测一次挥发性盐基氮。关于鲜度分级问题，我们认为食品标准是关系到人民健康的强制性标准，制定标准的先决条件是消费者食用后对身体不造成危害，因此作为卫生标准不分级为好，其鲜度指标只要符合标准规定，就应允许销售食用。