Could non-HDL-cholesterol be a better marker of atherogenic dyslipidemia in obstructive sleep apnea?

Background/objectiveObstructive sleep apnea (OSA) is independently associated with dyslipidemia, a surrogate marker of atherosclerosis. Low-density lipoprotein (LDL)-cholesterol is accepted as a major independent risk factor for cardiovascular disease. However, non-high-density lipoprotein (HDL)-cholesterol is a better marker of atherogenic dyslipidemia and recommended as a target of lipid lowering therapy. We aimed to assess the prevalence of atherogenic dyslipidemia, and relationship between OSA severity and serum LDL-cholesterol and non-HDL cholesterol levels in OSA patients.MethodsWe retrospectively evaluated treatment naïve 2361 subjects admitted to the sleep laboratory of a university hospital for polysomnography. All subjects’ lipid profile including total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, and non-HDL-cholesterol were measured.ResultsOut of 2361 patients (mean age 49.6 ± 11.9 years; 68.9% male, apnea-hypopnea index 36.6 ± 28.4/h), 185 (7.8%) had no OSA and 2176 (92.2%) had OSA. Atherogenic dyslipidemia prevalence was high (57–66%) in OSA patients, and especially increased in severe OSA compared to other groups (p < 0.05). Though total and LDL-cholesterol did not differ between those with and without OSA, non-HDL-cholesterol (p = 0.020), and triglycerides (p = 0.001) were higher and HDL-cholesterol levels (p = 0.018) were lower in OSA patients than non-OSA. Non-HDL-cholesterol was significantly correlated with OSA severity (p < 0.001) and hypoxia parameters (p < 0.01), whereas LDL-cholesterol showed no correlation.ConclusionsAtherogenic dyslipidemia is highly prevalent and non-HDL-cholesterol levels are significantly increased, predominantly in severe OSA patients. Non-HDL-cholesterol but not LDL-cholesterol, is significantly correlated with OSA severity and hypoxia parameters. Therefore, it could be better to use non-HDL-cholesterol, which is a guideline recommended target of lipid therapy, as a marker of atherosclerotic cardiovascular risk in OSA patients.     

不同性别的大学生心理健康调查研究

目的：探讨不同性别的大学生心理状况的影响。方法：以260名大学生为研究对象，采用SCL-90对不同性别的大学生进行了评定。结果：女生在抑郁、焦虑和恐怖方面高于男生，两者均存在显著性差异（P〈0．01）。结论：大学生中女性学生存在一定的心理缺陷，应针对性地开展专业教育，帮助大学生建立稳定、乐观和积极进取的健康心理。     

计算机专业人员心理健康状况的研究

目的 :探讨计算机专业人员的心理健康状况。方法 :以SCL 90为工具 ,对 71名计算机专业人员进行评估。结果 :计算机专业人员SCL 90总分和各因子显著低于全国常模 ;男性员工在躯体化、强迫、人际关系、焦虑、敌对、饮食和睡眠因子上得分显著高于女性员工 ;女性在恐怖因子得分显著高于男性。结论 :计算机专业人员心理症状较少 ,症状严重程度较低 ,男性员工自我感觉与自我评价方面低于女性员工。     

热休克蛋白90对大鼠缺氧心肌细胞丝氨酸苏氨酸蛋白激酶表达的影响

目的探讨内源性热休克蛋白90（HSP90）在缺氧心肌细胞丝氨酸苏氨酸蛋白激酶（AKT）相关信号通路中的作用。方法建立新生Wistar大鼠心肌细胞缺氧模型，将细胞分为正常组、缺氧组、加入HSP90特异性阻断剂格尔德霉素后再缺氧组（格尔德霉素＋缺氧组）。于缺氧后1、3、6、12、24、48h用噻唑蓝法检测心肌细胞的活力；缺氧24h，原位缺口末端标记法检测心肌细胞凋亡指数（AI）；缺氧1、3、6、12、24h，蛋白质印迹法检测大鼠心肌细胞中内源性HSP90及AKT表达水平。结果（1）缺氧24、48h，缺氧组、格尔德霉素＋缺氧组细胞活力均较正常组明显下降（P〈0．05）；格尔德霉素＋缺氧组细胞活力缺氧12h即开始明显下降，缺氧48h时明显低于缺氧组（P〈0．05）。（2）缺氧24h，缺氧组细胞AI为（10．7±1．2）％，明显高于正常组[（1．9±0．3）％．P〈0．05]；格尔德霉素＋缺氧组细胞AI为（26、3±5．3）％，明显高于缺氧组（P〈0．01）。（3）缺氧12h，缺氧组心肌细胞内源性HSP90及AKT表达水平高于正常组与格尔德霉素＋缺氧组；缺氧24h，缺氧组有所下降．格尔德霉素＋缺氧组则下降更明显。结论内源性HSP90对维持心肌细胞的活力有重要作用．缺氧心肌细胞AKT表达水平可受内源性HSP90表达水平的影响。     

大学生心理健康教育干预研究

目的　研究高校心理健康干预模式 ,提高大学生心理健康水平。方法　采取分层整群抽样的方法 ,运用SCL - 90自评量表对该院学生测试评分 ,分别进行实施心理健康干预模式 (心理教育、心理预防、心理训练 )前后状况调查 ,比较学生心理测试总体水平。结果　学校心理健康教育干预实施后一年 ,学生心理测试 8项因子分均值低于心理健康干预实施前 ,其中强迫、人际关系、焦虑、恐怖、偏执因子分实施前后有显著性差异 (P <0 0 5 )。结论　学校实施心理健康教育干预能有效地维护大学生心理健康 ,促进大学生心理发展 ,提高大学生心理素质     

Pterygium excision with free conjunctival autograft (FCG) versus postoperative strontium 90 (90Sr) beta-irradiation. A prospective study

In a prospective study the results of a pterygium excision in 54 patients (57 eyes) who underwent a superficial free conjunctival autograft (FCG) were compared to those of patients who were treated with postoperative90Sr-irradiation. In 51 cases the minimum follow-up was six months, the maximum follow-up seven years. We divided the study up into a randomized part and an open part. In the randomized part, surgery of a primary pterygium was performed in 25 eyes, of which 16 were treated with a FCG and compared with 9 eyes with primary pterygium surgery and postoperative90Sr beta-irradiation. In the same period 16eyes were treated because of a recurrent pterygium: 8 with FCG and 8 with90Sr-irradiation. In the open part of the study16 eyes with primary pterygium were successively treated with FCG alone. The results showed in the randomized, as well as in the open study on primary surgery with a minimum follow-up of six month, one recurrence in each of the FCG-groups (2 out of 31 eyes =6.4%), and no recurrences in the 90Sr-group(0%). In the randomized group of patients treated for a recurrent pterygium one recurrence developed in the FCG group (1 out of 8 eyes =12.5%) and one in the 90Sr-group (1 out of 7 =14.6%). Analysis of other clinical parameters showed that postoperative treatment with corticosteroids, nonsteroidal anti-inflammatory drugs, and artificial tears was necessary for a longer period in the FCG group than in the90Sr-group. This revised version was published online in August 2006 with corrections to the Cover Date.     

136例阿片类药物依赖者SCL-90的评定结果分析

本文应用ＳＣＬ－９０对１３６例阿片类药物依赖者进行测评，并与正常人进行对照分析。结果显示研究组总分及各因子分与正常组相比差异有显著性。说明毒品滥用人群心理问题严重，突出表现在焦虑、抑郁等几方面，提示戒毒治疗仅进行临床脱毒治疗是远远不够的，还必须重视这一人群的心理问题，并加以矫正，才能提高工作成效     

前列腺炎患者心理状况的相关因素分析

前列腺炎为泌尿外科最常见的疾病之一，约占泌尿外科门诊量的25％，该病呈慢性过程，治疗较为困难，复发率高。杨金瑞发现了84．3％前列腺炎患者表现为躯体化、焦虑、恐怖、精神病性和抑郁等方面的症状。为此．我们对62例前列腺炎患者进行了症状自评量表(SCL-90)，爱克森个性问卷(EPQ)，并与国内常模比较分析，现报告如下。     

延长血透机使用寿命的探讨

血液透析是治疗肾功能衰竭的有效方法,应用血液透析机挽救成千上万人的生命,在肾病的保守疗法、透析疗法、肾移植三种可选的治疗方案中,透析疗法是当前治疗肾病的最有效方法。本文对如何延长血透机的使用寿命进行了经验总结和探讨。