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The mechanism of maladaptive chronic stress response involves altered phosphorylation of the glucocorticoid receptor (GR). In this study, we investigated if important depressogenic vulnerability factors, such as neuroticism and self-reports of negative affective states, may be associated with alterations in levels of the GR and GR phosphoisoforms in peripheral blood mononuclear cells (PBMC) of healthy adults. In 21 women and 16 men we evaluated PMBC levels of total GR (tGR), GR phosphorylated at serine 211 (pGR-S211) and serine 226 (pGR-S226) and correlated these data with personality traits and current reports of stress, anxiety and depression. Also, we assessed plasma cortisol levels in all tested subjects. Our results showed that in women nuclear pGR-S226 was positively correlated with neuroticism and current reports of depression, anxiety and stress, while the ratio of nuclear pGR-S211/pGR-S226 was negatively correlated with reports of depression. None of the aforementioned correlations were significant in men. No significant relations between cortisol levels and any of GR parameters were observed. These preliminary findings highlight the value of GR phosphorylation-related research in identifying molecular biomarkers of depressogenic vulnerability, at least in women.  相似文献
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目的 观察分析不同年龄段平衡功能的不同表现,以及造成这种差异的主要因素.方法 将109例受试者按年龄划分为青少年组、中青年组和老年组.使用Swaystar检查装置记录7项平衡试验中躯体前后、左右晃动的角位移和晃动总面积.结果 (1)当视觉、本体觉或前庭觉传入信息受到干扰时,老年组平衡功能明显较差;单左腿站立时,老年组躯体晃动幅度明显大于另外两组(P<0.05),然而单右腿站立时,三组之间无统计学差异;(2)青少年阶段的姿势调节主要依赖于视觉.结论 随着年龄的增加,本体觉和前庭觉减退会导致平衡功能的降低;而在青少年时期视觉在姿势调节过程中占主要地位.  相似文献
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