鼻内窥镜下微波凝固治疗常年性变应性鼻炎近期疗效观察

目的 :观察微波凝固治疗常年性变应性鼻炎的近期疗效。方法 :患者随机分为两组 ,治疗组 96例经鼻内窥镜行微波凝固筛前神经及下鼻甲治疗 ;对照组 72例采用鼻内窥镜下 15 %硝酸银烧灼治疗 ,治疗部位同治疗组。结果 :在治疗结束 1个月后进行疗效评定。治疗组总有效率 10 0 % ,对照组总有效率 72 .2 % (P <0 .0 0 5 )。结论 :鼻内窥镜下微波凝固筛前神经及下鼻甲治疗常年性变应性鼻炎 ,具有视野清晰 ,操作简便 ,疗效显著等优点 ,有较好的临床应用价值。     

Voices of the Afflicted

Over the past 10 years, I have been privileged to conduct educational forums for audiences containing many recovering alcoholics or otherwise chemically dependent persons. In these forums about the addictive diseases and their treatment and research possibilities, significant interaction with the audience members occurs. During these interactions, certain anecdotal phenomena seem to predominate. The repetitive nature of these reports suggests the need for systematic investigation. As with editorial comments in major medical journals, observed phenomena and unanswered questions from those afflicted can be valuable in the generation of testable hypotheses. Perhaps the ideas presented herein will be useful in the development of future research on alcohol abuse and alcohol dependence.     

空管药物疗法治疗牙髓病和根尖周病疗效观察

用ＳＭＴＤ复合药物对牙髓病和根尖周病实施空管药物疗法。７８例１０３颗获得完整随访资料患牙经两年观察，９２．２％治愈率。文章介绍了治疗方法，讨论了空管药物疗法的愈合机理、优点、失败原因及其预防措施。     

高血脂症,动脉粥样硬化症的饮食防治

高脂肪,高糖类食物摄入量的增加与之相伴的不良饱含习惯,使血脂过高症和动脉粥样硬化症逐渐增多,已成为危害人们身体健康的严重病症。为了有效防治血脂过高症和动脉粥样硬化症的发生和发展,本文从发病原因入手,阐述了科学饮食,合理饮食的必要性和应采取的防治措施及注意事项。     

化疗联合放射治疗中晚期鼻咽癌疗效评价

目的:评价化疗加放射治疗中晚期鼻咽癌的临床效果.方法:对84例临床Ⅲ～Ⅳ期的鼻咽癌患者分别实施单纯放射治疗(单放)组33例和化疗加放射治疗(化放)组51倒行临床观察治疗前后的肿瘤大小,比较其近期的临床疗效(CR PR)及5年生存率.结果:单放组、化放组有效率(CR PR)分别为81.2%(17/33)、90.1%(46/51),P＜0.01,5年生存率分别为42.4%(14/33)、66.6%(34/51),P＜0.01.结论:化疗加放射治疗中晚期鼻咽癌可望提高临床疗效及延长患者的生存期.     

Praziquantel treatment of school children from single and mixed infection foci of intestinal and urogenital schistosomiasis along the Senegal River Basin: monitoring treatment success and re-infection patterns

Following major water development schemes in the 1980s, schistosomiasis has become a serious parasitic disease of children living in the Senegal River Basin. Both urogenital (Schistosoma haematobium) and intestinal (Schistosoma mansoni) schistosomiasis can be highly prevalent in school-aged children, with many individuals infected with both parasites. In order to investigate the transmission and re-infection dynamics of both parasite species, single and mixed infection foci at three villages (Nder and Temeye; S. mansoni and S. haematobium foci and Guia; S. haematobium focus) were studied. In each focus infected children were identified and selected for a 12-month study involving two treatments with praziquantel (40 mg/kg) three weeks apart at the beginning of the study and again 6 months into the study. Urine and stool samples were examined for schistosome eggs before and at 6 weeks and 6 months after chemotherapy. Prevalence and intensity of infection were recorded for each child at each time point. Before treatment, in all three villages, the prevalence and intensity of infection was extremely high for both S. mansoni (79–100%) and S. haematobium (81–97%). With the first round of chemotherapy sufficient cure rates (CRs) of both species were achieved in all villages (38–96%) with high egg reduction rates (ERRs) (97–99%). The data show that high and rapid re-infection rates occur, especially for S. mansoni, within a six-month period following treatment. Re-infection must be highly linked to ecological and seasonal factors. The persistence of S. mansoni in Nder could raise concern as levels of infection intensity remain high (geometric mean intensity at baseline 653 epg changed to 705 epg at 12 months) after four rounds of chemotherapy. This phenomenon could be explained by extremely rapid re-infection dynamics or a sub-optimal efficacy of praziquantel against S. mansoni in this village. High intensities in mixed infections may influence disease epidemiology and control warranting further studies. The disease situation in the SRB must be monitored closely and new treatment regimes should be designed and implemented to control schistosomiasis in the school-age population.     

阑尾消炎片联合抗生素治疗急、慢性阑尾炎96例临床体会

目的观察阑尾消炎片联合抗生素治疗急性阑尾炎的效果。方法采取阑尾消炎片口服,同时给予抗生素静点。结果本文报道96例,以用药一周为疗效统计依据。痊愈64例(66.66%),有效13例(13.54%),无效19例(19.79%),治愈率66.66%。结论口服阑尾消炎片联合抗生素口服或静点治疗阑尾炎效果很好,此种治疗方法可以免除一些不必要的手术,减少患者痛苦及经济上负担。     

Evidence-making hepatitis C cure: Towards a science that knows more carefully

There has been some controversy concerning the curative potential of new treatments for hepatitis C. This follows a systematic review of the Cochrane Collaboration questioning the clinical benefits of direct-acting antivirals (DAAs). This controversy has been debated as a matter of methods regarding how best to evidence treatment in an evidence-based medicine (EBM) approach. Drawing from science and technology studies (STS), we offer an alternative perspective. We propose a different way of thinking with evidence; one which treats ‘evidencing as performative’. Using the Cochrane review and its linked published responses as a resource for this analysis, we consider how hepatitis C cure is differently made-up through the knowledge-making practices performing it. We show how matters of apparent fact in evidence-based science are enacted as matters of clinical, social and ethico-political concern. We notice hepatitis C cure as a fluid object in negotiation. We highlight the limits of current debate to advocate a more critical and careful practice-based approach to knowing hepatitis C cure. This calls upon public health researchers to reflect on the performative work of their evidencing. We propose a ‘more-than’ EBM approach which treats ‘evidence-based’ science as an ‘evidence-making intervention’. We consider the implications of such an approach for the evidencing of public health interventions and for treating hepatitis C in the DAA era of ‘viral elimination’.     

高血压患者用药问题探讨

随着人们生活水平的提高,高血压患者的人数在逐年增加,但有些人常常忽视了高血压的危害,长期高血压可影响重要脏器心、脑、肾的功能;甚至导致脏器功能衰竭造成病残或死亡;同时也给患者造成很大负担。为提高患者对治病的顺应性、延缓高血压对重要脏器的损害,高血压患者的用药问题必须极高的关注。