布鲁菌病合并脑炎1例

正1临床资料患者男,56岁。因"间歇发热、头痛、乏力1个月,鼻出血、肢体和语言障碍4d"于2017年4月1日入院。患者近1个月间歇发热,体温最高39.0℃,伴乏力、头痛,未予重视。因家中养殖牛羊,怀疑布鲁菌病,入院前1周至当地疾病预防控制中心检测布鲁菌抗体回报试管凝集试验1∶50(++),未用药治疗。4d前患者无明确诱因突发鼻出血,量约600m L,至当地医院诊断"鼻内血管破裂",予对症治疗后出血停止。随     

布鲁菌病致颅内肉芽肿1例

病例资料患者男,18岁。以“间歇发热、乏力、多汗、头晕2个月,加重伴头痛1周”为主诉于2013年12月26日入院。患者入院前2个月无明确诱因出现发热,体温最高38.5℃,无畏冷寒战,伴乏力、多汗、头晕不适,食欲不振,于当地疾控中心化验布鲁菌病凝集试验1∶400,按“布鲁菌病”予阿米卡星静脉滴注,利福平口服治疗20 d(具体剂量不详),体温降至正常,但仍有乏力、头晕症状,体温平稳10 d后再次出现发热,体温达39.0℃,伴头痛,恶心、呕吐,呕吐物为胃内容物,非喷射性,于当地诊所静脉点滴药物治疗3 d(具体不详),症状无缓解。     

初筛核酸阴性的新型冠状病毒肺炎1例

Detection of nucleic acid is a method to first confirm COVID-19 theoretically, but it may show false negative result in clinical practice. This study indicates that suspected patients with COVID-19 cannot be ruled out easily because of once or twice negative results of nucleic acid detection. The epidemiology and radiological findings should be closely monitored. Dynamic test for viral nucleic acid is needed to avoid missed diagnosis, thus causing the spread of disease and missing the best time for early treatment. Clinical epidemiology, radiological findings, sampling time and criteria have posed significance to diagnose the disease and judge the severity.     

辽宁省重症新型冠状病毒肺炎17例临床特征分析

目的分析重症新型冠状病毒肺炎(新冠肺炎)患者的流行病学及临床特征。方法回顾性分析2020年1月22日-3月1日入住辽宁省2所新冠肺炎集中收治医院确诊新冠肺炎患者,符合《新型冠状病毒感染的肺炎诊疗方案(试行第七版)》定义的重型、危重型患者的流行病学及临床特征。结果纳入重症新冠肺炎17例,其中重型15例,危重型2例。17例患者均存在发热,14例发生肝损伤,5例肌酸激酶升高,6例乳酸脱氢酶升高,13例出现D-二聚体升高。所有患者胸部CT均呈双肺典型病毒性肺炎表现。所有患者均需要氧气支持治疗。患者主观感受发病至出现呼吸困难中位时间8 d(1~15 d),但实际开始接受氧气治疗时间为发病第3天(1~16 d)。所有患者均接受抗病毒治疗。8例使用糖皮质激素治疗。截至2020年3月16日,治愈出院16例,死亡1例。治愈患者发病至病毒核酸阴转中位时间(咽拭子、痰液RT-PCR检测)27 d(14~50 d)。结论重症新冠肺炎患者发热持续时间长、淋巴细胞计数早期下降,随病情改善后回升,可伴有肝损害、心肌损害等,双肺典型病毒性肺炎影像表现。经鼻湿化高流量吸氧可以满足大部分患者的氧气供应。小剂量的糖皮质激素可减轻肺部渗出、改善急性呼吸窘迫综合征,未发现严重不良反应。     

初筛核酸阴性的新型冠状病毒肺炎1例

Detection of nucleic acid is a method to first confirm COVID-19 theoretically, but it may show false negative result in clinical practice. This study indicates that suspected patients with COVID-19 cannot be ruled out easily because of once or twice negative results of nucleic acid detection. The epidemiology and radiological findings should be closely monitored. Dynamic test for viral nucleic acid is needed to avoid missed diagnosis, thus causing the spread of disease and missing the best time for early treatment. Clinical epidemiology, radiological findings, sampling time and criteria have posed significance to diagnose the disease and judge the severity.