全文获取类型
收费全文 | 4295篇 |
免费 | 228篇 |
国内免费 | 72篇 |
专业分类
耳鼻咽喉 | 860篇 |
儿科学 | 261篇 |
妇产科学 | 15篇 |
基础医学 | 454篇 |
口腔科学 | 4篇 |
临床医学 | 337篇 |
内科学 | 959篇 |
皮肤病学 | 32篇 |
神经病学 | 314篇 |
特种医学 | 228篇 |
外科学 | 61篇 |
综合类 | 503篇 |
现状与发展 | 1篇 |
一般理论 | 1篇 |
预防医学 | 184篇 |
眼科学 | 26篇 |
药学 | 186篇 |
4篇 | |
中国医学 | 143篇 |
肿瘤学 | 22篇 |
出版年
2024年 | 4篇 |
2023年 | 59篇 |
2022年 | 105篇 |
2021年 | 163篇 |
2020年 | 164篇 |
2019年 | 134篇 |
2018年 | 150篇 |
2017年 | 135篇 |
2016年 | 152篇 |
2015年 | 158篇 |
2014年 | 336篇 |
2013年 | 287篇 |
2012年 | 252篇 |
2011年 | 233篇 |
2010年 | 215篇 |
2009年 | 192篇 |
2008年 | 191篇 |
2007年 | 185篇 |
2006年 | 173篇 |
2005年 | 170篇 |
2004年 | 119篇 |
2003年 | 112篇 |
2002年 | 100篇 |
2001年 | 80篇 |
2000年 | 96篇 |
1999年 | 67篇 |
1998年 | 62篇 |
1997年 | 83篇 |
1996年 | 38篇 |
1995年 | 46篇 |
1994年 | 35篇 |
1993年 | 37篇 |
1992年 | 33篇 |
1991年 | 26篇 |
1990年 | 18篇 |
1989年 | 13篇 |
1988年 | 15篇 |
1987年 | 13篇 |
1986年 | 18篇 |
1985年 | 18篇 |
1984年 | 15篇 |
1983年 | 13篇 |
1982年 | 17篇 |
1981年 | 9篇 |
1980年 | 8篇 |
1979年 | 11篇 |
1978年 | 10篇 |
1977年 | 6篇 |
1976年 | 8篇 |
1973年 | 4篇 |
排序方式: 共有4595条查询结果,搜索用时 350 毫秒
1.
The purpose of this study is to show a very rare complication of acute cocaine poisoning, namely heart rupture. In the present case report, acute cocaine intoxication caused massive myocardial infarction, resulting in heart rupture and cardiac tamponade. A crime scene investigation found a dead body on the street in a drug dealing district. Examination of the body showed no external injuries. A thorough autopsy was performed showing massive cardiac tamponade with 510 ml of blood within the pericardium and full-thickness tissue lesion at the posterior wall of the left ventricle of 3.5 × 3 cm. Histological examination in hematoxylin and eosin was performed and confirmed the interruption of the posterior wall of the left ventricle with the presence of blood. In fact, although the correlation between cocaine and myocardial damage is well established, the relationship between heart rupture and acute cocaine intoxication is an extremely rare event. Moreover, since there are, to date, few reports of similar deaths, our report provides useful information regarding sudden death in a cocaine abuser. It is, therefore, of crucial importance to report this case to the scientific community. 相似文献
2.
3.
4.
M. R. D. Maslin S. K. Lloyd S. Rutherford S. Freeman A. King D. R. Moore K. J. Munro 《Journal of the Association for Research in Otolaryngology》2015,16(5):631-640
Individuals with sudden unilateral deafness offer a unique opportunity to study plasticity of the binaural auditory system in adult humans. Stimulation of the intact ear results in increased activity in the auditory cortex. However, there are no reports of changes at sub-cortical levels in humans. Therefore, the aim of the present study was to investigate changes in sub-cortical activity immediately before and after the onset of surgically induced unilateral deafness in adult humans. Click-evoked auditory brainstem responses (ABRs) to stimulation of the healthy ear were recorded from ten adults during the course of translabyrinthine surgery for the removal of a unilateral acoustic neuroma. This surgical technique always results in abrupt deafferentation of the affected ear. The results revealed a rapid (within minutes) reduction in latency of wave V (mean pre = 6.55 ms; mean post = 6.15 ms; p < 0.001). A latency reduction was also observed for wave III (mean pre = 4.40 ms; mean post = 4.13 ms; p < 0.001). These reductions in response latency are consistent with functional changes including disinhibition or/and more rapid intra-cellular signalling affecting binaurally sensitive neurons in the central auditory system. The results are highly relevant for improved understanding of putative physiological mechanisms underlying perceptual disorders such as tinnitus and hyperacusis. 相似文献
5.
AbstractBackground: Approximately, 30–40% of patients experienced hearing loss under regular hemodialysis.Objective: This study reviewed our experience on treating acute hearing loss in patients under regular hemodialysis over the past two decades.Methods: Twenty-six patients having acute hearing loss under hemodialysis were divided into two groups based on their etiologies. Sixteen patients (16 ears) with sudden sensorineural hearing loss (SSHL) were assigned to Group A and 10 patients (13 ears) with endolymphatic hydrops (EH) were assigned to Group B.Results: No significant difference was noted between Groups A and B, regardless of hemodialysis duration, clinical manifestation, underlying systemic diseases, blood examination, and vestibular test battery. In contrast, serum osmolality was significantly lower in Group B (292?±?11 mOsm/kg) than in Group A (310?±?11 mOsm/kg). Furthermore, Group B (40?±?14?dB) had better mean hearing level than Group A (87?±?21?dB) in the initial audiogram, and a higher hearing improvement rate (69%) than Group A (19%).Conclusions and significance: Both SSHL and EH are major causes for precipitating acute hearing loss in hemodialysis patients. Compared to SSHL, the less deteriorated MHL and lower serum osmolality in EH provide two clues for differentiating acute hearing loss in hemodialysis patients. 相似文献
6.
7.
8.
舒血宁注射液治疗突发性耳聋的疗效评价 总被引:2,自引:0,他引:2
目的:观察舒血宁注射液治疗突发性耳聋的疗效。方法:用舒血宁注射液治疗60例突发性耳聋,金纳多注射液作为对照。结果:舒血宁注射液,治疗突发性耳聋总有效率为94.3%,其中痊愈率114%;显效率45.7%;有效率37.1%,与进口金纳多注射液无明显差别。结论:舒血宁注射液是治疗突发性耳聋有效、安全、经济的新药物。 相似文献
9.
Jere Paavola Matti Viitasalo P?ivi J Laitinen-Forsblom Michael Pasternack Heikki Swan Ilkka Tikkanen Lauri Toivonen Kimmo Kontula Mika Laine 《European heart journal》2007,28(9):1135-1142
AIMS: Mutations in cardiac ryanodine receptors (RyR2s) are linked to catecholaminergic polymorphic ventricular tachycardia (CPVT), characterized by risk of polymorphic ventricular tachyarrhythmias and sudden death during exercise. Arrhythmias are caused by gain-of-function defects in RyR2, but cellular arrhythmogenesis remains elusive. METHODS AND RESULTS: We recorded endocardial monophasic action potentials (MAPs) at right ventricular septum in 15 CPVT patients with a RyR2 mutation (P2,328S, Q4,201R, and V4,653F) and in 12 control subjects both at baseline and during epinephrine infusion (0.05 microg/kg/min). At baseline 3 and during epinephrine infusion, four CPVT patients, but none of the control subjects, showed delayed afterdepolarizations (DADs) occasionally coinciding with ventricular premature complexes. In order to study the underlying mechanisms, we expressed two types of mutant RyR2 (P2,328S and V4,653F) causing CPVT as well as wild-type RyR2 in HEK 293 cells. Confocal microscopy of Fluo-3 loaded cells transfected with any of the three RyR2s showed no spontaneous subcellular Ca(2+) release events at baseline. Membrane permeable cAMP analogue (Dioctanoyl-cAMP) triggered subcellular Ca(2+) release events as Ca(2+) sparks and waves. Cells expressing mutant RyR2s showed spontaneous Ca(2+) release events at lower concentrations of cAMP than cells transfected with wild-type RyR2. CONCLUSION: CPVT patients show DADs coinciding with premature action potentials in MAP recordings. Expression studies suggest that DADs are caused by increased propensity of abnormal RyR2s to generate spontaneous Ca(2+) waves in response to cAMP stimulation. Increased sensitivity of mutant RyR2s to cAMP may explain the occurrence of arrhythmias during exercise or emotional stress in CPVT. 相似文献
10.
G. Van Goethem J.-J. Martin A. Lfgren I. Dehaene P. Tack M. Van Zandycke D. Ververken C. Ceuterick C. Van Broeckhoven 《European journal of neurology》1997,4(5):476-484
We studied 14 patients from three unrelated Belgian pedigrees with a familial mitochondrial disorder and multiple deletions of mitochondrial DNA (mtDNA). In one family with an oculopharyngeal presentation there is a clear autosomal dominant inheritance. Progressive external ophthalmoplegia (PEO), “ragged red fibres” (RRF) and multiple deletions of mtDNA are common to all three families. Therefore a diagnosis of autosomal dominant progressive ophthalmoplegia with multiple deletions of mtDNA (adPEO) was made in one family at least. Our data confirm the previous observations that adPEO is a systemic disorder rather than a pure myopathy. In our pedigrees frequently associated features include axonal peripheral neuropathy, dysphagia, psychiatric illness, and sudden death. Mild ataxia, pes cavus and mitral valve prolapse with associated mitral insufficiency also occur. In some cases onset is atypical with neuropathy, adolescent onset myopathy or psychiatric illness. In such cases the common features of PEO and muscle weakness always complete the clinical phenotype later during the course of the disease. Biochemical studies on mitochondrial fractions prepared from one patient's muscle, revealed no abnormalities of respiratory chain enzyme activities. 相似文献