MicroARN: la biología molecular como herramienta de predicción en preeclampsia

Preeclampsia is a disease with a significant incidence worldwide that is directly associated with 15% of maternal deaths. This is usually characterized by the presence of hypertension and proteinuria, which manifests itself from the middle of pregnancy. MicroRNAs are single-stranded RNA molecules that act primarily by degrading transcribed messenger RNA or inhibiting microRNA translation. Placental microRNAs play a role in the growth and function of the placenta, their potential use as diagnostic biomarkers is considered feasible due to the ability to enter the maternal circulation and be detectable in maternal plasma.     

High-performance multiplex drug-gated CAR circuits

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课程思政融入《口腔生物学》课堂教学的探索

立德树人作为我国高等学校的育人的方向,是高校的立身之本。育人先育德,教师理应把立德树人作为一种教育理念贯穿于课堂教学中,做到育人育才有机结合,在专业课授课过程中注重对思想政治教育元素的提炼和融入,加强对学生的思想政治教育,注重对学生世界观、人生观和价值观的正确引导和塑造,为我国社会主义建设培养合格的建设者和接班人。文章以《口腔生物学》课堂教学为例,探讨了课程思政教育背景下新型课堂教学的设计思路与理念,课堂教学中思政元素的提炼和融入的措施和方法。通过将思政教育元素有机融入课堂教学各环节,既提升了课堂教学的效果,又圆满实现了育人目标。     

Periodic patterns in Rodentia: Development and evolution

Mammalian periodic pigment patterns, such as spots and stripes, have long interested mathematicians and biologists because they arise from non‐random developmental processes that are programmed to be spatially constrained, and can therefore be used as a model to understand how organized morphological structures develop. Despite such interest, the developmental and molecular processes underlying their formation remain poorly understood. Here, we argue that Arvicanthines, a clade of African rodents that naturally evolved a remarkable array of coat patterns, represent a tractable model system in which to dissect the mechanistic basis of pigment pattern formation. Indeed, we review recent insights into the process of stripe formation that were obtained using an Arvicanthine species, the African striped mouse (Rhabdomys pumilio), and discuss how these rodents can be used to probe deeply into our understanding of the factors that specify and implement positional information in the skin. By combining naturally evolved pigment pattern variation in rodents with classic and novel experimental approaches, we can substantially advance our understanding of the processes by which spatial patterns of cell differentiation are established during embryogenesis, a fundamental question in developmental biology.     

壮药材滇桂艾纳香及其易混品种东风草和高艾纳香比较研究

目的： 建立壮药材滇桂艾纳香专属性检验方法。方法： 采用基原鉴别、性状鉴别、显微鉴别、薄层鉴别、分子生物学及特征图谱等方法对滇桂艾纳香及其易混品种东风草和高艾纳香进行对比研究。结果： 三者的根、茎、叶性状基本相同，区别点在于滇桂艾纳香头状花序小（直径0.5~0.8 cm），东风草头状花序大（直径1.5~2 cm），高艾纳香头状花序具密集的长绒毛；三者的根、茎横切面，粉末显微特征基本相同，高艾纳香具基部膨大的非腺毛；薄层鉴别（1）中高艾纳香比滇桂艾纳香和东风草少1个斑点；薄层鉴别（2）中滇桂艾纳香比东风草和高艾纳香少1个特征斑点；ITS2序列N-J树聚类分析显示三者具有良好的单系性，三者种间最小遗传距离均大于种内最大遗传距离；与滇桂艾纳香对照图谱相比，东风草平均相似度为0.962，高艾纳香平均相似度仅为0.789。结论： 高艾纳香与滇桂艾纳香区别较大，不宜混用，在日常使用中应注意甄别；东风草与滇桂艾纳香在性状、显微、薄层、分子生物学、特征图谱等方面相似度较高，在对二者进行充分的药理活性以及临床试验等基础上，可考虑作为滇桂艾纳香的替代品使用，以缓解药用资源不足的问题。     

Cabozantinib for relapsed neuroblastoma: Single institution case series

Relapsed high‐risk neuroblastoma has few effective therapies currently available or in development. Cabozantinib is an Food and Drug Administration approved multitargeted tyrosine kinase inhibitor for select adult malignancies with preclinical data suggesting efficacy against neuroblastoma. A safe and tolerable dose has been identified for children, but its efficacy remains unknown. We describe four children with relapsed metastatic neuroblastoma treated with cabozantinib. All four patients had extended disease control (two complete responsesfor >12 months, 2 stable disease >6 months) with manageable predictable toxicities requiring dose reduction in two patients. We discuss the potential for the use of cabozantinib in neuroblastoma.     

Transforming vaccine development

The urgency to develop vaccines against Covid-19 is putting pressure on the long and expensive development timelines that are normally required for development of lifesaving vaccines. There is a unique opportunity to take advantage of new technologies, the smart and flexible design of clinical trials, and evolving regulatory science to speed up vaccine development against Covid-19 and transform vaccine development altogether.