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991.
尿钙及尿微量白蛋白检测在妊高征早期诊断中的临床意义 总被引:11,自引:0,他引:11
目的 评价尿钙及尿微量白蛋白检测在妊高征早期诊断中的临床意义。方法 收集98 例孕24~32 周健康孕妇的24 小时尿样,采用自动生化仪测定尿钙排泄量,放射免疫法测定尿微量白蛋白的排泄量,按最终是否发生妊高征分成妊高征组(14 例) 和正常妊娠组(84 例) 。结果 妊高征组尿钙排泄量为(1-43±0-37) mmol/24h ,正常妊娠组为(3-26±0-75) mmol/24h,妊高征组尿钙排泄量显著低于正常妊娠组( P< 0-005) 。妊高征组尿微量白蛋白排泄量为(12-68 ±6-81) μg/24h ,正常妊娠组为(6-08±3-48) μg/24h,妊高征组尿微量白蛋白排泄量显著高于正常妊娠组( P< 0-05)。结论 在妊高征临床症状出现4~8 周之前,即出现尿钙排泄量减少及尿微量白蛋白排泄量增多。这一特征可作为妊高征早期诊断的指标。 相似文献
992.
993.
目的 探讨孕鼠高血糖对胎鼠胰岛β细胞分泌胰岛素功能的影响。方法 28 只妊娠 S D 大鼠随机分成两组,实验组在妊娠晚期持续性静脉输注高渗葡萄糖;对照组同期输注无菌蒸馏水。采用胎鼠胰岛细胞进行胰岛素抽提实验、胰岛素释放试验及灌流试验,研究胎鼠胰岛β细胞功能的变化。结果 实验组胎鼠每个胰腺内胰岛素平均水平为(3 329 .81 ±163 .39)ng;单位重量胰腺组织胰岛素水平为(158 .56 ±23 .34)ng/mg。对照组胎鼠胰腺内胰岛素平均水平为(2 390 .04 ±151 .39)ng ;单位重量胰腺组织胰岛素水平为(125 .79 ±17 .97)ng/mg 。两者比较,差异有显著性( P< 0 .05) 。在低糖或高糖 Hanks 液中温育胰腺组织2 小时,实验组胎鼠胰岛素释放量:低糖时为(24 .22 ±4 .63)ng/mg ;高糖时为(73 .73 ±5 .94)ng/mg 。对照组胎鼠胰岛素释放量:低糖时为(20 .52 ±2 .31)ng/mg ;高糖时为(53 .35 ±7 .53)ng/mg 。两组比较,差异有显著性( P< 0 .05) 。在胰岛素灌流试验中,实验组胎鼠胰岛素分泌时相高峰出现早且峰值高于对照组。结论 相似文献
994.
Anne Elizabeth Chambers Craig Fairbairn Marco Gaudoin Walter Mills Irene Woo Raj Pandian Frank Z. Stanczyk Karine Chung Subhasis Banerjee 《Reproductive biomedicine online》2019,38(2):159-168
Research question
Circulating soluble LH-HCG receptor (sLHCGR) is a first-trimester marker for screening pregnancy pathologies and predicts premature or multiple births before fertility treatment. Oestradiol per oocyte at ovulation induction predicts IVF treatment outcomes. We asked whether sLHCGR levels are stable during fertility treatment and whether, alone or with oestradiol, they could improve prediction of fertility treatment outcomes.Design
Serum sLHCGR, anti-Müllerian hormone [AMH] and oestradiol were measured in patients undergoing IVF. Antral follicle count before ovarian stimulation and oocyte yield were used to establish sLHCGR– oocyte ratio (SOR), sLHCGR– antral follicle ratio (SAR), oestradiol at trigger per oocyte (oestradiol–oocyte ratio [EOR]) and oestradiol at trigger per antral follicle (oestradiol–antral follicle ratio [EAR]).Results
The relatively stable sLHCGR was negatively related to AMH when oocyte yield was high. The sLHCGR levels were proportional (r?=?0.49) to oestradiol at early cycle (day-3). Pregnancy and live birth were highest at low sLHCGR (≤1.0 pmol/ml) and SOR (≤ 0.1 pmol/ml/oocyte). A total of 86–89% of live births in IVF treatment were within the cut-off parameters of SAR and SOR (0.5 pmol/ml) and EAR and EOR (380 pg/ml). For failed pregnancy, age, SOR and EOR together had positive and negative predictive values of 0.841 and 0.703, respectively.Conclusions
sLHCGR levels are negatively related to AMH when oocyte yield is high. High early cycle sLHCGR is associated with elevated day-3 oestradiol. Low sLHCGR and SOR are indicators of increased clinical pregnancy and live birth rates. Patient age and SOR, combined with EOR, might improve prediction of IVF treatment outcomes. 相似文献995.
Kim Paquette Stephanie Markey Stephanie Roberge Mario Girard Emmanuel Bujold Suzanne Demers 《Journal d'obstetrique et gynecologie du Canada》2019,41(1):59-63
Background
Lower uterine segment (LUS) thickness in the third trimester of gestation is associated with the risk of uterine scar defect at delivery. It was suggested that first trimester residual myometrial thickness (RMT) could also predict uterine scar defect at delivery.Objective
This study sought to correlate the RMT measured at the site of uterine scar in the first trimester with the LUS thickness measured in the third trimester.Methods
This was a prospective cohort study of women with a singleton pregnancy and a single prior low-transverse CS. All participants underwent an evaluation of uterine scar by using transvaginal ultrasound at 11 to 13 weeks, including the presence of a scar defect and measurement of RMT; and a second evaluation at 35 to 38 weeks, combining both transvaginal and transabdominal ultrasound, for the measurement of LUS thickness. Spearman's correlation test was used to compare first and third trimester measurements.Results
A total of 166 eligible participants were recruited at mean GA of 12.7?±?0.5 weeks. We observed an absence of correlation between first trimester RMT and third trimester LUS thickness (correlation coefficient 0.10; P?=?0.20). First trimester RMTs below 2.0?mm and below 2.85?mm are poor predictors of third trimester LUS thickness below 2.0?mm (sensitivity, 8% and 23%; specificity, 98% and 87%; positive predictive value, 25% and 14%, respectively).Conclusion
There is a poor correlation between first trimester RMT and third trimester LUS thickness in women with a previous CS. First trimester RMT should not be used to inform women on their risk of uterine rupture or to guide clinical management. 相似文献996.
M. Diéguez Felechosa C. Sánchez Ragnarsson M. Riestra Fernández P. Suárez Gil E. Delgado Alvarez E. Menéndez Torre 《Clínica e investigación en ginecología y obstetricia》2019,46(1):9-14
Objective
To estimate the effectiveness of selective versus universal screening for thyroid dysfunction (TD) during pregnancy.Material and methods
Cross-sectional study applying a selective screening protocol, based on the presence of TD risk factors (RF), in a cohort of pregnant women with a positive universal screening result in the Oviedo Healthcare District. Two hundred and twenty pregnant women with TD were studied between April 2010 and March 2011.Results
Selective screening identified 83.6% of pregnant women with TD. The most prevalent RF were maternal age ≥ 30 years (70.5%), history of miscarriage (21.8%) and family history of thyroid disease (20.9%). Excluding the age factor, only 51.8% of the pregnant women included in the group had risk factors.Conclusions
Selective screening identifies a high proportion of pregnant women with TD but at the expense of screening a large number of women, so it does not appear to be an effective strategy. 相似文献997.
The purpose of this study was to evaluate the usefulness of low-field MRI pelvimetry and to correlate the results with X-ray
pelvimetry. A total of 19 women underwent low-field MRI pelvimetry. Mediosagittal and transverse planes were used to measure
the diameters of the minor pelvic cavity. Correlations between MRI and X-ray pelvimetry were 0.96 for the sagittal inlet,
0.94 for the sagittal outlet, 0.93 for the transverse diameter (diameter transversa, DT) and 0.94 for the bispinous distance
(interspinous distance, IS). The repeatability of the measurements was good. For fetuses with cephalic presentation it was
also possible to determine the biparietal diameter (BPD). Low-field MRI pelvimetry was well accepted by the patients. The
scanning time was less than 6 min, which is comparable with the time of X-ray examination with two planes. Magnetic resonance
imaging provides a reliable method to image pelvic structures and soft tissue without ionizing radiation.
Received 2 October 1995; Revision received 27 December 1995; Accepted 19 June 1996 相似文献
998.
Changing management of gallstone disease during pregnancy 总被引:7,自引:4,他引:3
R. E. Glasgow B. C. Visser H. W. Harris M. G. Patti S. J. Kilpatrick S. J. Mulvihill 《Surgical endoscopy》1998,12(3):241-246
Background: Symptomatic gallstones may be problematic during pregnancy. The advisability of laparoscopic cholecystectomy (LC) is uncertain.
The objective of this study is to define the natural history of gallstone disease during pregnancy and evaluate the safety
of LC during pregnancy.
Methods: Review of medical records of all pregnant patients with gallstone disease at the University of California, San Francisco,
from 1980 to 1996.
Results: Of approximately 29,750 deliveries, 47 (0.16%) patients were treated for gallstone disease, including biliary colic in 33,
acute cholecystitis in 12, and pancreatitis in two. Conservative treatment was attempted in all patients but failed in 17
(36%) cases. Two patients required combined preterm Cesarean-section cholecystectomy and 10 required surgery in the early
postpartum period for persistent symptoms. Seventeen patients required cholecystectomy during pregnancy for biliary colic
(10), acute cholecystitis (six), and pancreatitis (one). Three patients were treated with open cholecystectomy. Fourteen patients
underwent LC at a mean gestational age of 18.6 weeks, mean OR time of 74 min, and mean length of stay of 1.2 days. Hasson
cannulation was utilized in 11 patients. Reduced-pressure pneumoperitoneum (6–10 mmHg) was used in seven patients. Prophylactic
tocolytics were used in seven patients, with transient postoperative preterm labor observed in one. There were no open conversions,
preterm deliveries, fetal loss, teratogenicity, or maternal morbidity.
Conclusions: In past years, symptomatic gallstones during pregnancy were managed conservatively or with open cholecystectomy. LC is a
feasible and safe method for treating severely symptomatic patients.
Received: 3 April 1997/Accepted: 5 July 1997 相似文献
999.
抗孕唑啉对啮齿类动物终止妊娠药效学研究 总被引:1,自引:0,他引:1
目的:研究抗孕唑啉(L14105)的终止妊娠作用及其作用靶部位。方法:用多种啮齿类动物观察终止早孕及中孕作用;用组织学和细胞培养法观察对细胞的损伤;放射配基分析对子宫胞浆孕酮受体的结合力。结果:L14105对小鼠、大鼠、金黄地鼠与豚鼠均有较强的抗早孕作用,并可致豚鼠中孕堕胎;对体外培养人蜕膜细胞具杀伤力,早孕大鼠用药后24~48h蜕膜细胞开始损伤、胚胎吸收;对大鼠子宫胞浆孕酮受体结合力微弱。结论:L14105对多种啮齿类动物具有很强的终止早孕与中孕活性,其作用靶部位可能为蜕膜细胞。 相似文献
1000.
A two-page questionnaire was distributed to 304 members of the American Urogynecology Society. Ninety-nine of the 149 respondents reported that they had performed continence surgery on patients who specifically stated their desire for future childbearing. One hundred and eleven recommended the Burch colposuspension, 29 favored the sling procedure, and others advocated different procedures. Urologists as a subset more often recommended either a sling or needle suspension. Twenty-eight percent of respondents felt a trial of labor and vaginal delivery was indicated following incontinence surgery, but 40% stated that they would always perform cesarean section in these patients. A total of 40 vaginal deliveries and 47 cesarean sections were reported. When postpartum continence status was known, only 73% of women who had vaginal deliveries were continent, whereas 95% were continent following cesarean section. Fisher's exact test revealed this to be a statistically significant difference (P=0.0344).The opinions expressed in this article do not reflect the views or opinions of the United States Navy or the Department of Defense.Editorial Comment: This study presents interesting information about current practice trends regarding a difficult medical situation without any clear guidelines. However, whether any true clinical consensus was reached based on the data collected is questionable. The study does, however, serve to open the topic of how to manage the incontinent female who desires further childbearing, for further study. Clearly, more rigorous objective data are needed before far-reaching statements can be made regarding the route of delivery following incontinence surgery. 相似文献