主体性语篇教学模式教改实验

自语法翻译法问世以来 ,人们在经历了一个多世纪的外语教学法探索后 ,由注重外因的教学法转移到了重视内因教学法的研究 ,即教学法的研究重点从重视教师转移到了重视学习者。而目前的研究往往重视了学习者的因素 ,却忽视了教师的因素 ,在实践中许多大学英语教师还是奉行“教师至上”的原则或是放任学生进行自学。笔者认为以上做法有失偏颇 ,并尝试主体性语篇教学模式进行教学。它融合教师的主导作用与学生的主体性 ,充分发挥学生自主学习的积极性 ,通过教师的联想式的语篇教学模式 ,使学生学会学习 ,进而想学 ,乐学 ,构建自己的学习和知识体…     

Rosiglitazone down-regulates lipopolysaccharide-induced expression of CD40 and intercellular adhesion molecule 1 in rat peritoneal mesothelial cells through a NF-κB dependent mechanism

Objective To investigate the effect and mechanism by which PPARγ ligand, rosiglitasone, regulates the expression of CD40 and intercellular adhesion molecule 1 (ICAM-1) in the rat peritoneal mesothelial cells (RPMCs) induced by lipopolysaccharide (LPS). Methods RPMCs were harvested from Sprague-Dawley rat peritoneal cavity and maintained under defined in vitro conditions. The cells were randomly divided into groups as follows: medium, LPS (5 mg/L), LPS (5 mg/L)+BAY11-7085(5 μmol/L, NF-κB inhibitor), rosiglitazone (10 μmol/L or 20 μmol/L, peroxisome proliferator-activated receptor γ activator), LPS (5 mg/L)+rosiglitazone (10 μmol/L)+GW9662 (3 μmol/L, peroxisome proliferator-aetivatcd receptor γ antagonist), and LPS (5 mg/L)+vehicle (DMSO 0.2 ml/L). The expressions of CD40 and ICAM-1 RNA in RPMCs were examined by RT-PCR after 3 hour treatment, and the protein expressions of CD40, ICAM-1, p-NF-κB p65 and p-IκBα were examined by Western blot or immunofluorescence after 24 hour treatment. Results Following treatment with LPS, both the expressions of CD40 and ICAM-1 protein in RPMCs were up-regulated significantly (P<0.05), and the phosphoralation of p65 was increased greatly (1.10±0.17 vs 0.55±0.06, P<0.05). BAY11-7085 (5 μmol/L) significantly decreased the protein expression of p-p65 (0.22±0.11 vs 1.10±0.17, P<0.01), CD40 (0.34±0.02 vs 0.50±0.06, P<0.05) and ICAM-1 (0.35±0.16 vs 0.74±0.03, P<0.05). Pretreated with rosiglitazone for 3 h then added with LPS for 1 h, the levels of p-p65, CD40 and ICAM-1 in RPMCs were significantly decreased compared with those of LPS group (0.77±0.08 vs 0.90±0.10, P相似文献   

肾病综合征并发乳糜腹水2例报告

肾病综合征是临床常见的肾脏疾病,可并发乳糜腹水[1],但报道并不多.我们在临床中遇到2例,现报道如下.     

近视眼的屈光度、眼轴、角膜屈光力的相关性探讨

目的：探讨近视眼的屈光度、眼轴、角膜屈光力之间的相关关系以及近视的成因。方法：将204例(348只眼)近视患者分为三组：低度近视组62眼(屈光度＜-3．0D）；中度近视组159眼(屈光度-3．0D～-6．0D)；高度近视组127眼(屈光度＞-6．0D)。测量患者眼的屈光度、角膜屈光力及眼轴，与近视程度、角膜屈光力、眼轴的关系。结果：在低度近视组，62只眼屈光度与眼轴长度无显著相关性，而屈光度与角膜水平径、垂直径屈光力呈正相关(P＜0．05)，相关具有显著性；在中度近视组和高度近视组屈光度与眼轴长呈正相关(P＜0．05)，相关具有显著性，且随近视度数的增加，与眼轴长的相关系数呈递增趋势，而中、高度组患者眼屈光度与角膜水平径及垂直径屈光力无显著相关性。结论：在近视性屈光不正的影响因素中，低度近视眼患者受角膜屈光力的影响相对较大，而眼轴的作用甚微；在中、高度近视眼患者中，眼轴长是影响近视程度的主要因素，而角膜屈光力几乎不起作用。     

检测血清VEGF、CEA、TSGF在肿瘤中的临床意义

目的研究血清VEGF、CEA在肿瘤诊断中联合应用价值以及肿瘤患者中血清VEGF与TSGF相关性.方法收集结直肠癌、肺癌患者以及正常人静脉血标本,ELISA法检测血清VEGF含量,放射免疫法检测CEA,化学显色法检测TSGF.结果结直肠癌患者中,血清CEA阳性率为32.4%,VEGF阳性率为54.1%,两者联合应用时阳性率为73.0%.血清VEGF与TSCF在结直肠癌中的相关系数为r=0.355(P＜0.01),肺癌患者中为r=0.612(P＜0.05).结论联合检测CEA和VEGF可以明显提高结直肠癌患者的阳性率,肿瘤患者血清中VEGF与TSGF的含量显著相关.     

鼻窦内窥镜治疗慢性鼻窦炎316例

近年来 ,鼻窦内窥镜手术治疗慢性鼻窦炎、鼻息肉取得很好的疗效 ,而鼻窦内窥镜术后及时处理手术成功关系密切。我科 1 999年 3月～ 2 0 0 1年 6月接受鼻窦内窥镜术 31 6例术后随访 2 5 4例 ,取得了一定的疗效。1　临床资料1 .1　一般资料　 31 6例中 ,男 1 86例 ,女 1 30例 ,年龄 1 0～ 70岁 ,平均 34.5岁。双侧鼻窦炎 2 2 8例 ,单侧鼻窦炎 88例 ,伴有鼻息肉 1 37例。均有鼻塞流涕 ,部分有头痛、头昏、嗅觉减退等症状 ,鼻腔内可见中鼻道引流不畅 ,中鼻道有脓涕和 (或 )息肉样新生物。按照中华耳鼻咽喉科学会慢性鼻窦炎鼻息肉分型分期标准 [1…     

MICROVASCULAR DECOMPRESSION FOR HEMIFACIAL SPASM - TECHNICAL NOTES AND COMPLICATION PREVENTION : EXPERIENCE OF 338 CASES

Objective To summarize our clinical experience of microvascular decompression (MVD)for medically intractable hemifacial spasm(HFS) patients with emphasis on microsurgical manipulation and to improve cure rate and avoid surgical complications. Methods Three hundred and thirty-eight patients with HFS underwent MVD under general anesthesia . With the help of "zero retraction" technique, prosthesis can be properly inserted between offending vessel loop and affected facial nerve REZ in a "rolling ball" fashion under operative microscope. Results Surgical intervention achieved high relief rate of 91 .4% and no major complications, with low recurrence rate of only 3.2% after averaging more than two years' follow-up ( M = 32 months). Conclusion It is possible to approach to the facial nerve REZ with "zero retraction", which is fundamentally important to clear from cranial nerve and cerebellar injury. Skilled microsurgical technique along with correct recognition and mobilization of offending vessels are a must     

专职夜班对护士心身状态影响的分析

由于护士职业的特殊性需要经常上夜班和换班，快速换班有可能破坏人体正常的日节律，会产生各种心身障碍。为此，我们对专职夜班护士心身状态进行了探讨，旨在为制订有利于护士心身健康的护士上班制度提供参考。     

护患纠纷发生的原因及防范措施

随着人们自我保护意识和法律意识的不断增强以及《医疗事故处理条例》的实施,护患纠纷的发生数量不断增加,给临床护理工作带来很大冲击,造成了护患之间的关系紧张,甚至影响了医院正常的医疗秩序,对此我们应采取一定的防范措施,杜绝或减少纠纷的发生。     

人口腔毛滴虫感染调查及虫株保存方法

<正> 口腔毛滴虫分布甚广,世界各地均有报告,感染率马来亚为32%;德国为4——53.4%;美国为16.5——30.6%;英国为10%;我国上海为59.1%;杭州为37.41%〔1〕为了解邯郸地区人口腔毛滴虫感染率,同时对本虫在低温情况下进行了保存试验研究,现总结如下: