脊髓损伤后bFGF和GFAP的变化及其意义

目的：研究脊髓损伤后碱性成纤维细胞因子和胶质纤维酸性蛋白的变化及其两者的相关性,探讨脊髓损伤后脊髓的自身保护机制以及星形胶质细胞在脊髓损伤中的作用。方法：用免疫组织化学,组织学染色和图像分析的方法检测损伤脊髓碱性成纤维细胞及胶质纤维酸性蛋白表达的动态变化。结果：脊髓损伤后1d损伤脊髓中碱性成纤维细胞的表达明显增高,7d达到高峰,14d末回落,而胶质纤维酸性蛋白表达则在1－14d内呈进行性增高趋势,两指标相关性显著（r=0.777,P=0.001),结论：脊髓损伤后反应性星形细胞胶质化对脊髓的再生和自身修复起着重要作用,提示脊髓本身存在自身保护机制。     

Remissions in maternal depression and child psychopathology: a STAR*D-child report

Context  Children of depressed parents have high rates of anxiety, disruptive, and depressive disorders that begin early, often continue into adulthood, and are impairing. Objective  To determine whether effective treatment with medication of women with major depression is associated with reduction of symptoms and diagnoses in their children. Design  Assessments of children whose depressed mothers were being treated with medication as part of the multicenter Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial conducted (between December 16, 2001 and April 24, 2004) in broadly representative primary and psychiatric outpatient practices. Children were assessed by a team of evaluators not involved in maternal treatment and unaware of maternal outcomes. Study is ongoing with cases followed at 3-month intervals. Setting and Patients  One hundred fifty-one mother-child pairs in 8 primary care and 11 psychiatric outpatient clinics across 7 regional centers in the United States. Children were aged 7 to 17 years. Main Outcome Measures  Child diagnoses based on the Kiddie Schedule for Affective Disorders and Schizophrenia; child symptoms based on the Child Behavior Checklist; child functioning based on the Child Global Assessment Scale in mothers whose depression with treatment remitted with a score of 7 or lower or whose depression did not remit with a score higher than 7 on the Hamilton Rating Scale for Depression. Results  Remission of maternal depression after 3 months of medication treatment was significantly associated with reductions in the children's diagnoses and symptoms. There was an overall 11% decrease in rates of diagnoses in children of mothers whose depression remitted compared with an approximate 8% increase in rates of diagnoses in children of mothers whose depression did not. This rate difference remained statistically significant after controlling for the child's age and sex, and possible confounding factors (P = .01). Of the children with a diagnosis at baseline, remission was reported in 33% of those whose mothers' depression remitted compared with only a 12% remission rate among children of mothers whose depression did not remit. All children of mothers whose depression remitted after treatment and who themselves had no baseline diagnosis for depression remained free of psychiatric diagnoses at 3 months, whereas 17% of the children whose mothers remained depressed acquired a diagnosis. Findings were similar using child symptoms as an outcome. Greater level of maternal response was associated with fewer current diagnoses and symptoms in the children, and a maternal response of at least 50% was required to detect an improvement in the child. Conclusions  Remission of maternal depression has a positive effect on both mothers and their children, whereas mothers who remain depressed may increase the rates of their children's disorders. These findings support the importance of vigorous treatment for depressed mothers in primary care or psychiatric clinics and suggest the utility of evaluating the children, especially children whose mothers continue to be depressed.      

多节段颈髓型颈椎病诊疗进展

多节段颈髓型颈椎病(CSM)是指在影像学上存在多个节段颈椎椎体后缘骨质增生、骨赘形成及椎间盘变性、突出等多种病理改变,造成对颈髓或硬脊膜前方多个平面的压迫。它以椎间盘退变为基本病理基础,继发椎间盘突出、椎间不稳,相邻椎间盘后缘形成含有椎体缘骨赘的隆起物,在椎管前方压迫脊髓或支配脊髓的血管,导致不同程度的脊髓功能障碍。1病因正常颈椎管有足够的空间容纳颈髓、脑脊膜、韧带及硬膜外脂肪。国人正常C3~C7的椎管矢状径男性为16~17mm,女性为15~16mm。颈椎病的发生与颈椎管矢状径的狭窄密切相关,而椎管狭窄的原因又分为静态因素和…     

局部应用丝裂霉素C预防椎板切除术后硬膜外粘连的实验研究

目的:探讨局部应用丝裂霉素C(mitomycinC,MMC)预防椎板切除术后硬膜外粘连的效果。方法:手术切除12只SD大鼠第一腰椎椎板,造成0.2cm×0.5cm硬脊膜裸露区,随机分为2组,每组6只。实验组以棉片浸透0.1mg/mlMMC,对照组以棉片浸透生理盐水置于裸露的硬脊膜后5min。术后第4周处死动物,测定其硬膜外组织中胶原组织面积及成纤维细胞记数,同时根据Rydell分级标准评价粘连程度。结果:实验组无明显硬膜外粘连,对照组形成致密的硬膜外粘连。实验组胶原面积及成纤维细胞记数较对照组明显降低。结论:局部应用MMC可有效预防椎板切除术后硬膜外粘连的形成。     

论著性文稿中摘要的书写

论著性文稿须附中、英文摘要 ,内容包括目的、方法、结果 (应给出主要数据 )、结论四部分 ,各部分冠似相应的标题 ,采用第三人称撰写 ,不用“本文”、“作者”等主语。考虑到我国读者可参考中文原著资料 ,为节省篇幅 ,中文摘要可简略些 ( 2 0 0字左右 ) ,英文摘要则要相对具体些 ( 4 0 0个实词左右 )。英文摘要尚应包括文题、作者姓名 (汉语拼音 )、单位名称、单位所在城市名及邮政编码、国别。作者应列出前 3位 ,3位以上加“ｅｔａｌ” ;作者不属同一单位时 ,在第一作者姓名右上角加“ ” ,同时在单位名称首字母左上角加“ ”。例如 :Ｚ…     

原发性子宫淋巴瘤的MRI诊断（5例报告及文献复习）

目的探讨子宫淋巴瘤的MRI特点,以提高对其认识及诊断能力。方法回顾性分析5例经临床及病理证实的原发性子宫淋巴瘤的MRI表现并作文献复习。3例患者行MR平扫及增强检查,2例行平扫,行横断面SE T1WI、FSE T2WI以及矢状面、冠状面FSE T2WI。增强病例均行DWI扫描。结果5例患者病理结果均为弥漫性大B细胞淋巴瘤,其中肿瘤位于宫颈2例,宫体2例,1例宫体宫颈均受累,最大者16cm×12cm,最小者直径3cm。MRI表现T1WI均呈等低信号（以肌肉信号为参照）,信号均匀,无明显出血信号改变,T2WI呈稍高信号,其中4例肿瘤内均可见多个形态不规则结节灶,且之间可见条索状低信号带分隔,未见明显囊变及坏死信号,1例呈均匀高信号,无结节灶及条索状分隔。增强扫描1例呈轻度均匀强化,边界清晰,2例可见肿瘤内结节灶轻度强化,而结节间条状分隔线强化程度略高于结节灶。4例T2WI肿瘤内可见子宫内膜线或宫颈黏膜线完整存在于肿瘤内。3例DWI呈显著高信号。结论子宫淋巴瘤MRI表现有一定特征性,MRI对该病的诊断具有很高的价值。