全文获取类型
收费全文 | 43926篇 |
免费 | 2358篇 |
国内免费 | 112篇 |
专业分类
耳鼻咽喉 | 611篇 |
儿科学 | 849篇 |
妇产科学 | 857篇 |
基础医学 | 5616篇 |
口腔科学 | 2160篇 |
临床医学 | 3318篇 |
内科学 | 11340篇 |
皮肤病学 | 828篇 |
神经病学 | 3622篇 |
特种医学 | 814篇 |
外科学 | 5680篇 |
综合类 | 233篇 |
一般理论 | 16篇 |
预防医学 | 3949篇 |
眼科学 | 941篇 |
药学 | 3076篇 |
中国医学 | 181篇 |
肿瘤学 | 2305篇 |
出版年
2023年 | 284篇 |
2022年 | 191篇 |
2021年 | 844篇 |
2020年 | 460篇 |
2019年 | 958篇 |
2018年 | 1733篇 |
2017年 | 1082篇 |
2016年 | 1073篇 |
2015年 | 1340篇 |
2014年 | 1452篇 |
2013年 | 2096篇 |
2012年 | 4050篇 |
2011年 | 4122篇 |
2010年 | 2135篇 |
2009年 | 1529篇 |
2008年 | 3417篇 |
2007年 | 3507篇 |
2006年 | 3361篇 |
2005年 | 3257篇 |
2004年 | 2853篇 |
2003年 | 2588篇 |
2002年 | 2398篇 |
2001年 | 147篇 |
2000年 | 124篇 |
1999年 | 140篇 |
1998年 | 114篇 |
1997年 | 90篇 |
1996年 | 92篇 |
1995年 | 87篇 |
1994年 | 72篇 |
1993年 | 72篇 |
1992年 | 59篇 |
1991年 | 59篇 |
1990年 | 30篇 |
1989年 | 33篇 |
1988年 | 20篇 |
1987年 | 20篇 |
1986年 | 21篇 |
1985年 | 31篇 |
1984年 | 43篇 |
1983年 | 27篇 |
1982年 | 48篇 |
1981年 | 31篇 |
1980年 | 41篇 |
1979年 | 12篇 |
1978年 | 14篇 |
1976年 | 12篇 |
1975年 | 16篇 |
1974年 | 21篇 |
1973年 | 10篇 |
排序方式: 共有10000条查询结果,搜索用时 78 毫秒
91.
92.
93.
94.
Johana Béné Aurélie Jacobsoone Patrick Coupe Marine Auffret Samy Babai Dominique Hillaire‐Buys Marie‐Josèphe Jean‐Pastor Marlène Vonarx Annie Vermersch Anne‐Fleur Tronquoy Sophie Gautier 《Fundamental & clinical pharmacology》2015,29(1):112-114
To report three cases of bullous pemphigoid in patients treated with vildagliptin. Case 1: An 86‐year‐old woman presented with bullous pemphigoid after 1 month of treatment with vildagliptin and metformin. After introduction of clobetasol, the symptoms resolved although vildagliptin was continued. However, the skin lesions reappeared 3 months later. Sustained remission was achieved only after definitive withdrawal of vildagliptin. Case 2: A 79‐year‐old man presented with bullous pemphigoid after 37‐month treatment with gliclazide, vildagliptin and metformin. The disease at first responded to clobetasol but 3 months later the lesions reappeared. They finally regressed when the gliptin was discontinued. Case 3: A 77‐year‐old woman, treated with gliclazide and vildagliptin for 26 months, presented with bullous pemphigoid, which responded well to discontinuation of the gliptin and topical clobetasol. Gliptins are new molecules for treatment of type 2 diabetes mellitus, which have been suspected of implication in bullous pemphigoid. Such cases have been described in the literature (seven with vildagliptin and three with sitagliptin). In nine of these cases, the gliptin was associated with metformin, but the latter had never been considered responsible. The mechanism implicated in the development of bullous pemphigoid has not yet been clearly identified, but may involve a modified immune response or alteration of the antigenic properties of the epidermal basement membrane. These reports support the risk of bullous pemphigoid in patients exposed to gliptins. 相似文献
95.
96.
Mark Padilla José Félix Colón-Burgos Caroline Mary Parker Nelson Varas-Díaz Armando Matiz-Reyes 《Global public health》2020,15(5):691-703
ABSTRACTThe Dominican Republic is thought to have significant epidemics of illicit drug use but lacks surveillance and formal analyses of the policy context of drug prevention and treatment services. We conducted an institutional ethnography of 15 drug service organisations in Santo Domingo and Boca Chica, Dominican Republic, to explore barriers and resources for drug abuse prevention and treatment. Here, we present a typology of drug service organisations based on their services, methods, and approach. We then draw on interviews with representatives of drug service institutions to describe the primary barriers to drug treatment and prevention services for drug users. We conclude with a focus on the policy priorities that could improve the conditions of health care for marginalised drug users in the Dominican Republic. 相似文献
97.
Talita da Silva Mendes de Farias Ariclécio Cunha de Oliveira Sandra Andreotti Fernanda Gaspar do Amaral Patrícia Chimin André Ricardo Alves de Proença Francisco Leonardo Torres Leal Rogério Antonio Laurato Sertié Amanda Baron Campana Andressa Bolsoni Lopes Arnaldo Henrique de Souza José Cipolla‐Neto Fabio Bessa Lima 《Journal of pineal research》2015,58(3):251-261
Melatonin, the main hormone produced by the pineal gland, is secreted in a circadian manner (24‐hr period), and its oscillation influences several circadian biological rhythms, such as the regulation of clock genes expression (chronobiotic effect) and the modulation of several endocrine functions in peripheral tissues. Assuming that the circadian synchronization of clock genes can play a role in the regulation of energy metabolism and it is influenced by melatonin, our study was designed to assess possible alterations as a consequence of melatonin absence on the circadian expression of clock genes in the epididymal adipose tissue of male Wistar rats and the possible metabolic repercussions to this tissue. Our data show that pinealectomy indeed has impacts on molecular events: it abolishes the daily pattern of the expression of Clock, Per2, and Cry1 clock genes and Pparγ expression, significantly increases the amplitude of daily expression of Rev‐erbα, and affects the pattern of and impairs adipokine production, leading to a decrease in leptin levels. However, regarding some metabolic aspects of adipocyte functions, such as its ability to synthesize triacylglycerols from glucose along 24 hr, was not compromised by pinealectomy, although the daily profile of the lipogenic enzymes expression (ATP‐citrate lyase, malic enzyme, fatty acid synthase, and glucose‐6‐phosphate dehydrogenase) was abolished in pinealectomized animals. 相似文献
98.
Jose M. Morales Jose Angel Martinez-Flores Manuel Serrano Maria José Castro Francisco Javier Alfaro Florencio García Miguel Angel Martínez Amado Andrés Esther González Manuel Praga Estela Paz-Artal Antonio Serrano 《Journal of the American Society of Nephrology : JASN》2015,26(3):735-745
In the current immunosuppressive therapy era, vessel thrombosis is the most common cause of early graft loss after renal transplantation. The prevalence of IgA anti–β2-glycoprotein I antibodies (IgA-aB2GPI-ab) in patients on dialysis is elevated (>30%), and these antibodies correlate with mortality and cardiovascular morbidity. To evaluate the effect of IgA-aB2GPI-ab in patients with transplants, we followed all patients transplanted from 2000 to 2002 in the Hospital 12 de Octubre prospectively for 10 years. Presence of IgA-aB2GPI-ab in pretransplant serum was examined retrospectively. Of 269 patients, 89 patients were positive for IgA-aB2GPI-ab (33%; group 1), and the remaining patients were negative (67%; group 2). Graft loss at 6 months post-transplant was significantly higher in group 1 (10 of 89 versus 3 of 180 patients in group 2; P=0.002). The most frequent cause of graft loss was thrombosis of the vessels, which was observed only in group 1 (8 of 10 versus 0 of 3 patients in group 2; P=0.04). Multivariate analysis showed that the presence of IgA-aB2GPI-ab was an independent risk factor for early graft loss (P=0.04) and delayed graft function (P=0.04). There were no significant differences regarding patient survival between the two groups. Graft survival was similar in both groups after 6 months. In conclusion, patients with pretransplant IgA-aB2GPI-ab have a high risk of early graft loss caused by thrombosis and a high risk of delayed graft function. Therefore, pretransplant IgA-aB2GPI-ab may have a detrimental effect on early clinical outcomes after renal transplantation. 相似文献
99.