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Angel Fernandez-Flores Angela Hermosa-Gelbard Alberto Pérez José Antonio Bello Fernando Cabo 《Journal of cutaneous pathology》2020,47(10):976-982
The relationship between autoinflammatory and autoimmune conditions has been demonstrated in recent decades. Several autoimmune conditions exhibit an autoinflammatory component, which can manifest in various ways. Neutrophilic dermatosis in the context of lupus erythematosus (LE) is one example. Otherwise, neutrophils are rare in LE, except for the bullous variant and nonbullous neutrophilic LE. In this paper, we describe a case of scarring alopecia due to LE that stopped responding to a treatment that had been effective for years. The biopsy specimen demonstrated the presence of neutrophils in the inflammatory infiltrate. A treatment with dapsone was prescribed and yielded rapid improvement. This first case of scarring alopecia in the context of nonbullous neutrophilic LE emphasizes the importance of the infiltrate in determining the optimal therapeutic choice. 相似文献
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José Bañuls Laura Francés Maria Niveiro Gloria Juan Luca Schneller-Pavelescu Francisco Illán José Sánchez-Payá Eduardo Nagore Ignacio Moreno Aimilios Lallas Pedro Zaballos 《The Journal of dermatology》2020,47(9):1058-1062
Polarized dermoscopy enables visualization of linear shiny white structures in melanomas, thought to be due to the existence of fibrosis in the dermis. Our objective was to establish the existence of two types of linear shiny white structures and assess their association with different histological structures. We performed a cross-sectional study including all non-acral, non-facial melanomas from our hospital with linear shiny white structures. The outcome variable was the type of linear shiny white structures: shiny white streaks and white strands. We evaluated their association with explanatory variables that may affect the reflectance of melanomas and Breslow index. We used χ2 statistics and also calculated the sensitivity and specificity of each linear shiny white structure to predict those variables. We detected linear shiny white structures in 118 melanomas. Regarding shiny white streaks, we only found a statistically significant positive relationship with fibrosis in the papillary dermis. Regarding white strands, we found statistically significant and positive relationships with hyperkeratosis, Breslow index of 0.8 mm or more and acanthosis. Sensitivity and specificity study revealed that the presence of shiny white streaks was the most sensitive (81.7%) and specific (72.3%) for fibrosis in the papillary dermis, and presence of white strands was the most sensitive (91.1%) and specific (85.7%) for hyperkeratosis. 相似文献
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Straetmans Jos M. J. A. A. Stuut Marijn Wagemakers Sanne Hoebers Frank Kaanders Johannes H. A. M. Speel Ernst Jan M. Melchers Willem J. G. Slootweg Piet Kremer Bernd Lacko Martin Takes Robert P. 《European archives of oto-rhino-laryngology》2020,277(6):1753-1761
European Archives of Oto-Rhino-Laryngology - Debate on the extent of treatment of neck metastasis of cancer of unknown primary tumors (CUPs) is still ongoing. In two Dutch tertiary referral... 相似文献
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Sánchez-González José-María Alonso-Aliste Federico 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2019,257(7):1561-1567
Graefe's Archive for Clinical and Experimental Ophthalmology - We aimed to present the visual results obtained in 100 small incision lenticule extraction (SMILE) refractive surgeries,... 相似文献
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Dunia Alarkawi M Sanni Ali Dana Bliuc Natalia Pallares Cristian Tebe Leena Elhussein Fergus J Caskey Nigel K Arden Yoav Ben-Shlomo Bo Abrahamsen Adolfo Diez-Perez Julio Pascual María José Pérez-Sáez Jacqueline R Center Andrew Judge Cyrus Cooper Muhammad K Javaid Daniel Prieto-Alhambra 《Journal of bone and mineral research》2020,35(5):894-900