曲唑酮治疗海洛因依赖患者勃起功能障碍的临床观察

目的:观察曲唑酮治疗海洛因依赖患者勃起功能障碍(ED)的疗效和不良反应.方法:将94例海洛因依赖伴ED患者随机分为二组.治疗组42例,使用曲唑酮治疗4周,对照组52例.二组均在住院期间使用美沙酮替代递减脱毒治疗.进行二组比较观察疗效与不良反应,以不良反应量表和实验室检查评定其不良反应.结果:治疗组痊愈1例,显著进步6例,进步9例,有效率为38.10%;而对照组痊愈0例,显著进步1例,进步3例,有效率为7.69%.二组有效率比较统计学上存在非常显著性差异(P＜0.001).不良反应主要是轻度的口干、头痛、困倦.结论:曲唑酮对海洛因依赖伴ED患者有较好的疗效,不良反应少,安全性较高,可在脱毒期间使用.     

曲唑酮治疗失眠、抑郁及焦虑并存患者临床观察

目的:通过门诊和住院患者使用曲唑酮后睡眠情况的观察,评价曲唑酮治疗失眠、抑郁和焦虑的临床价值。方法:将患有失眠、抑郁及焦虑的患者60例分为A、B、C三组,每组20例,分别采用阿米替林、曲唑酮50mg、曲唑酮100mg治疗。采用汉密尔顿焦虑抑郁量表和匹兹堡睡眠量表检测,睡眠日记记录睡眠质量,比较三组治疗效果。结果:在总睡眠时间、睡眠潜伏期、觉醒次数、停用艾司唑仑时间等方面B组和C组均优于A组。结论:曲唑酮治疗失眠、焦虑及抑郁并存患者有显著疗效。     

抗抑郁药对脱毒依从性和成功率的影响

目的观察抗抑郁药对脱毒依从性和成功率的影响。方法对91例戒毒患者,采用随机双盲的方法分为3组,在使用美沙酮治疗过程中,分别给予盐酸安非他酮、盐酸曲唑酮和安慰剂,比较患者住院天数和脱毒成功率。结果盐酸安非他酮和盐酸曲唑酮组的住院天数和脱毒成功率均高于安慰剂组。但盐酸安非他酮和盐酸曲唑酮组间差异无统计学意义。结论抗抑郁药可明显提高自愿戒毒患者的脱毒依从性和脱毒成功率。     

Efficacy and tolerability of controlled-release trazodone in depression: A large multi-centre study in general practice

Summary

A double-blind, parallel-group study was carried out to compare the efficacy and tolerability of a controlled-release tablet formulation of trazodone with the standard trazodone tablet. Three hundred and forty-seven general practice patients with depressive symptoms were recruited into the trial. Patients were randomly allocated to receive either 1 controlled-release trazodone (150?mg) tablet at night or 1 standard trazodone (150?mg) tablet at night for a period of 6 weeks. Assessments of efficacy, tolerability and compliance were made at study entry and after 1, 2, 4 and 6 weeks of study medication. Seventy-seven patients withdrew from the study of whom 44 were in the standard trazodone tablet group and 33 were in the controlled-release trazodone tablet group. There were no statistically significant differences between treatment groups in any of the measures of efficacy (global severity, global improvement and Hamilton Depression Rating Scales 17– and 21-item). Major improvements in patients' condition were shown in all efficacy measures by the end of the study in comparison with study entry. Treatment differences were small but were numerically in favour of the controlled-release tablet formulation. As expected, a greater proportion of side-effects were reported during the first 2 weeks of treatment in both groups. Treatment differences, revealed in a five symptom adverse event checklist used throughout the study, were small, although in favour of the controlled-release tablet in the majority of cases, but not statistically significant.     

盐酸曲唑酮治疗酒依赖戒断后心理及生理症状的临床研究

目的 探讨盐酸曲唑酮治疗酒依赖戒断后患者焦虑、抑郁、失眠等心理及躯体症状的有效性和安全性.方法 采用随机、双盲、安慰剂对照的方法把100例符合纳入和排除标准的患者分成盐酸曲唑酮组和安慰剂组.每个患者均口服盐酸曲唑酮或安慰剂每日3次,每次1片,疗程均为8周.于治疗后第l,2,4,8周末分别进行汉密顿焦虑量表(HAMA)、汉密顿抑郁量表(HAMD)、匹兹堡睡眠质量指数(PSQI)、副反应量表(TESS)评分.1年后调查复饮情况.结果 有81例完成治疗,19例因提前出院或失访未完成治疗脱失.盐酸曲唑酮组(41例)汉密顿焦虑量表、汉密顿抑郁量表及匹兹堡睡眠质量指数评分治疗后与治疗前比较,总分值逐渐下降,2周后上述3项评分和安慰剂组(40例)分别比较差异有显著性(P<0.05);1年后复饮率盐酸曲唑酮组(24.4%)明显低于安慰剂组(55.0%,P<0.05).治疗后两组副反应量表评分比较差异无显著性(P>0.05).结论 盐酸曲唑酮能有效改善酒依赖戒断后患者焦虑、抑郁及失眠症状,且能有效降低复饮率.

Abstract：

Objective To explore the efficacy and safety of anxiety, depression, insomnia and other psychological and physical symptoms after trazodone treated in patients with alcohol dependence. Methods 100 patients whose met the inclusion and exclusion criteria were divided into trazodone group and the placebo group with a randomized, double-blind, placebo-controlled method. Each of the patients was oral trazodone, or placebo 3 times a day, each time a course of treatment was 8 weeks. Hamilton Anxiety Scale ( HAM A) , Hamilton Depression Rating Scale(HAMD) , Pittsburgh Sleep Quality Index(PSQI) , side effects scale (TESS) score and the necessary examinations were used to assess. Survey the re-drink situation after 1 year. Results 81 patients completed treatment, 19 patients were discharged or lost due to early treatment failure loss. In Trazodone group (41 cases) , the HAMA, HAMD and PSQI score before treatment and after treatment, total scores decreased gradually after 2 weeks of the three score and comfort dose group (40 cases) were the difference was statistically significant (P< 0. 05 ) ;recovery drink rate of trazodone group was significantly lower than the placebo group (24.4% vs 55. 0% , P<0. 05) after 1 year. After treatment, the side effects scale score difference was not statistically significant (P> 0. 05 ). Conclusion Improve trazodone treat alcohol dependence withdrawal anxiety, depression and insomnia effectively. Found no adverse drug reactions and the safety is high. Reduce the recovery drink.     

百乐眠胶囊联合曲唑酮治疗中度抑郁症的临床研究

目的研究百乐眠胶囊联合盐酸曲唑酮片治疗中度抑郁症的临床疗效。方法选取2016年3月—2019年3月在汉中市中心医院进行治疗的120例中度抑郁患者为研究对象,将所有患者随机分为对照组和治疗组,每组各60例。对照组患者口服盐酸曲唑酮片,初始剂量为50 mg/次,次日开始可增加50 mg/次,3次/d;治疗组患者在对照组基础上口服百乐眠胶囊,4粒/次,2次/d。两组患者持续治疗4周。观察两组的临床疗效,比较两组的汉密顿抑郁量表(HAMD)评分、抑郁自评量表(SDS)评分,以及脑源性神经营养因子(BDNF)、多巴胺(DA)、5-羟色胺(5-HT)水平。结果治疗后,对照组和治疗组的总有效率分别为86.67%、96.67%,两组比较差异有统计学意义(P0.05)。治疗后,两组患者HAMD评分和SDS评分均显著降低,同组治疗前后比较差异有统计学意义(P0.05);并且治疗组患者HAMD评分和SDS评分明显低于对照组,两组比较差异有统计学意义(P0.05)。治疗后,两组患者BDNF、DA、5-HT水平均显著升高,同组治疗前后比较差异有统计学意义(P0.05);并且治疗组患者BDNF、DA、5-HT水平均明显高于对照组,两组比较差异有统计学意义(P0.05)。结论百乐眠胶囊联合盐酸曲唑酮片治疗中度抑郁症具有较好的疗效,能改善临床症状,调节BDNF、DA、5-HT水平,安全性较好,具有一定的临床推广应用价值。     

三种药物治疗方案治疗广泛性焦虑症的成本-效果分析

目的探讨三种药物治疗方案治疗广泛性焦虑症的成本-效果分析。方法对三种药物治疗方案治疗广泛性焦虑症进行成本-效果分析,并对可能影响因素做敏感性分析。结果阿普唑仑组不良反应总发生率明显高于曲唑酮和坦度螺酮两组(χ2=7.68和7.44,P<0.01),坦度螺酮组性功能障碍发生率明显高于曲唑酮组(χ2=16.03,P<0.01),坦度螺酮组嗜睡发生率明显低于曲唑酮和阿普唑仑组两组(χ2=16.51和11.94,P<0.01)。成本-效果分析示坦度螺酮组成本-效果比最高(16.78),阿普唑仑组最低(7.73)。敏感性分析示降价后成本-效果比与原分析基本一致。结论阿普唑仑治疗广泛性焦虑症治疗方案较曲唑酮和坦度螺酮为佳。     

盐酸曲唑酮加西地那非治疗早泄的临床观察

作者自2002年1月至2003年3月用盐酸曲唑酮、西地那非加心理治疗与体能训练治疗早泄40例,方法为同房前2小时口服盐酸曲唑酮50 mg,前1小时口服西地那非50 mg,结果治愈28例,改善8例,无效4例,治愈率达61%,取得了较为满意的疗效.     

曲唑酮联合乌灵胶囊治疗失眠症疗效观察

目的 观察曲唑酮联合乌灵胶囊治疗失眠症的临床疗效.方法 将60例失眠患者随机分为治疗组与对照组各30例,治疗组予曲唑酮联合乌灵胶囊治疗,对照组予以艾司唑仑治疗,分别治疗2、4周后观察两组患者的临床疗效.结果 两组患者在治疗第2周末时疗效无明显差异（P＞0.05）;治疗组在治疗第4周末时疗效优于对照组,差异有统计学意义（P＜0.05）.两组均未出现严重不良反应.结论 曲唑酮联合乌灵胶囊治疗失眠症疗效好,不良反应少,可在临床推广应用.     

持续小剂量伐地那非联合曲唑酮治疗早泄疗效观察

目的 探讨持续小剂量伐地那非联合曲唑酮并配合心理行为治疗早泄的临床疗效.方法 136例早泄患者随机分为实验组(小剂量伐地那非+曲唑酮+行为疗法)和对照组(曲唑酮+行为疗法),记录治疗前后阴道内射精潜伏期(IELT)并进行组内和组间比较,同时记录夫妻对性生活的满意情况.结果 治疗前,实验组和对照组IELT分别为(0.87±0.29)min、(0.93±0.35)min,治疗后分别为(4.62±2.31)min、(2.35±1.25)min,差异有统计学意义(P＜0.01),且实验组IELT较对照组相比差异有统计学意义(P＜0.01).夫妻双方对性生活的情况:实验组满意率(62.3%)和总满意率(满意加基本满意)(89.8%)分别优于对照组满意率(37.3%)和总满意率(67.2%),差异均有统计学意义(P＜0.01).结论 持续小剂量伐地那非联合曲唑酮并配合心理行为治疗早泄在延长IELT,改善夫妻双方性生活满意度方面明显优于盐酸曲唑酮配合心理行为疗法组,持续小剂量给药可以起到增强疗效和降低副作用,两药合用在治疗早泄方面有一定的应用前景.